Dr.Bart
#81
10,000 calories a day. That’s INSANE !
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mccoy
#82
It would seem to be so. Inigo San Milan describes the dietary regimes of the Tour De France Emirates cyclists and says that they must by no means go catabolic, otherwise performance is seriously compromised. Everything rotates around replenishing expended calories and glycogen storage.
The upper arms of cyclists are more like drumsticks but that evidently is not catabolism but rather an optimization for the specific duty of cycling, less passive mass to carry, the one strictly necessary to maneuver the bike.
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mccoy
#83
That’s really insane, although the average, from the article, would be more like 9000 Kcals, his BMR must have been huge given the enormous mitochondrial mass, plus 6 hours in water, which means BMR+energy expenditure+thermal expenditure…Which justifies a 3.6 times expenditure with respect to an average 80kg guy (9000/2500), whose intake rarely will drop to 2000 like written in the article.
They are evidently people born with a different metabolism, like Tadej Pogacar, whose lactate concentration under 5 W kg-1 effort is similar to that of a regular dude while walking…
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@mccoy @Dr.Bart
Some answers are here:
https://www.sciencedirect.com/science/article/pii/S0891584924006002
Regular aerobic training (AT) remodels skeletal muscle into a more oxidative, fatigue-resistant phenotype underpinned by changes in substrate utilization (i.e., altered % carbohydrate and fatty acid oxidation at relative work intensities), mitochondrial content, efficiency and capillarization [7,8]
Regular resistance training (RT) facilitates muscle remodeling toward growth and increased force output [18]
High-intensity interval-type training (HIIT) is a popular form of training that encompasses higher energy demand aerobic exercise [21] interspersed with rest and requires higher force than traditional lower aerobic power activity [22,23]. While there have been some studies examining the impact of intensity on post-exercise MPS [[24], [25], [26]] and signalling [23], the conclusion is less than clear as to whether HIIT resembles AE or RE in terms of the phenotypic changes it induces. Most evidence suggests HIIT definitely promotes mitochondrial biogenesis [27] and can lead to hypertrophy [22], although this appears to be less than that achieved with RE.
Wilkinson et al. (2008) [25] hypothesized that the divergent phenotypes observed with chronic AT and RT are derived by the differential repeated stimulation of predominantly myofibrillar and mitochondrial protein synthesis elicited by RE and AE, respectively.
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Neo
#85
Saw this thread from last year. How are you doing on those values nowadays?
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My LDL and ApoB are now both 48. My HBA1C was down to 5.4 but is now back to 5.8 as I am on vacation and haven’t been watching my diet. I’ll get a better HBA1C measurement in 6 months.
However my LDL and ApoB seem surprisingly diet independent.
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So, I believe that supplementing Pendulum’s Akkermansia doesn’t have any real effect.Will you continue supplementing with Akkermansia?
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I have stopped the Akkermansia as it is quite expensive.
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Neo
#90
Did you have clean before after bloodwork, if so did you see an impact?
One year ago, my HBA1C was 5.7. I added 500 mg of Metformin and took Akkermansia for 2 months. My blood work 6 months later had an HBA1C of 5.4. Two weeks ago, my HBA1C was 5.8. However my Metformin intake has been spotty as I have been on vacation.
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This is interesting info on leucine requirements. Much higher than I had been led to believe for older adults (78mg/kg x 92kg = 7g) but if leucine is 10% of protein (roughly) then I only need 70 grams a day on average.
Still to come is the extra if any needed for exercise recovery and adaptation.
https://www.sciencedirect.com/science/article/abs/pii/S0002916524007196
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Hi, Beth mentioned Glycerin/Glycerol in the FMD kit. You mentioned trying it. Which did you use? I did FMD about 6 times and 5 more with my wife. My meals were homemade also. Could not seem to find anything like the FMD Glycerol… Especially how it helped with energy during the days 2-5. Below was a good link with alternatives and I bought the Amazon “LiveLong Nutrition Glycerol Monostearate GMS Powder” which was horrible trying to mix with water (anyone knows how would be appreciated)! When i did the FMD with my wife i used the left over FMD Gycerin from her kit and like i said, could really tell the difference. At that time i was not going to the Gym so could not comment on if FMD hurt the workouts I do these days.
I averaged loosing 4-10 lbs per FMD fast but gained most back in about a month and fasted roughly every 2-3 months for the first 4 FMD kits. After about the 8th time, over 2 years-ish, i lost 10 lbs. and managed to keep it off for over a year… But that might be coincidental to switching from good ale to light beer… LOL, But also from that fasting period I also tried one meal a day (OMAD) for a couple months… Im now on 2 meals a day (18-6), skipping breakfast but with GHEE in my coffee every morning. Here is the FMD DIY I have used info from and it references links to Glycerin.
Fasting Mimicking Diet: Do-It-Yourself Plan [5-Day Menu]
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The immediate and strong reaction that you described to a statin reminds me of the reaction I had to bempedoic acid. I got the worst leg cramps in the middle of the night that I have ever had (I am prone to leg cramps but keep them at bay with magnesium). It took three days before I comprehended that it had to be the BA that was causing the cramps, and sure enough, as soon as I stopped taking it, no more cramps.
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mccoy
#95
@MickeyMike30, I bought some glycerin in the pharmacy, and they told me it was edible.
I have been able to regain weight after every FMD, after about one month or less. However, in my case the most powerful intervention to trigger catabolism was a low-carb diet and even worse a low-carb, low protein diet. In 2022 I started a low carb diet which, after 2 years, caused a loss of 22 pounds (both fat and muscle tissue).
I started eating carbs again at the beginning of 2024 and could only gain 5 pounds in 10 months. The low glucose signal might have brought about some epigenetic change, plausibly chronically lowering the systemic mTor protein -kinase activity.
In the past I have observed that a significant glucose signal, even without worrying about protein, was able to cause significant muscle protein synthesis.
Maybe the mTOR response to the upstream signals differs in different individuals.
@Deborah_Hall Yes, we all have unique biologies and will have different reactions to different compounds/supplements/medicines. What may work for you might be toxic for me. However, I believe most things will work similarly for most people. You have to keep your eyes open for what your Achilles heel is.
Also, don’t buy a year’s supply of medicine without trying it out for a month first.
Does anyone need some Rosuvastatin? 
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