#636

“I often use BPC-157 500 mcg/day subcutaneously for individuals post operatively as you only get one chance to heal, or for chronic non-healing wounds or acute injuries, or older injuries that aren’t healing”

May I ask - are the injections as close to the injury site as possible? Intramuscular rather than subcutaneous injection when injury is in a muscle?

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#637

It might be better to get it closer to the site. We have times with knee surgery where we’ll get the orthopedist to inject BPC into the joint (or I can do it post procedure). I don’t think we have evidence this is a superior approach to simple SC.

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#638

I have a new Peptide I am interested in: LyP-1

It can recognise and reduce human arterial plaque…

https://www.sciencedirect.com/science/article/abs/pii/S0168365916304540

Harry Perkins Institute of Medical Research are wanting to develop a drug based on it. But they’re not ready for trials yet (& will initially only treat patients with peripheral artery disease).

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#639

Logically I think you’re correct.
I have had autologous plasma injections several times and, although there may be some slight systemic “spillover” effect the idea is to get it as close to where it’s needed as possible.

BTW, if you want a new definition of excruciating pain; try plasma injections in the sole of your foot for plantar fasciitis! Even with anaesthetic I taught medical staff a few new words!

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#640

Just got a boat load of peptides this afternoon and couldn’t wait to try them all. Holly and Molly. Never I have experienced such amazing feeling. My body is buzzing with pleasure and all my muscle and joint pressure point gone. Holly macaroni have we ever been barking the effing wrong tree for so long with these useless supplements. Even my tinnitus decreased like 80%, i literally have to stop and listen to know that i even have tinnitus any longer. Can we please award 1 million noble prices to the person that invented these absolutely amazing substances. Having said that in case I won’t be writing on these boards in next couple days, most likely I didn’t wake up from my sleep tomorrow morning at all LOL. Actually, I’m looking forward to tomorrow morning because for me the easiest to tell if some supplement/substance is having a good/bad effect is to listen to your body and how you feel the following day when you wake up.

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#641

Are you sure those are peptides and not actual Molly?

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#642

They might as well be, but whoever cooked them this way, more power to them as far as I’m concerned.

#643

Ok, share with us what you used that is causing this euphoria!!

Holly macaroni… loving that phrase!

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#645

I tied to inject into an inflamed bunion. Couldn’t do it.

Since we’re all in the experimental phase, I think that I’ll try IM for the SS-31. The dose is said to be as effective at 4 mg as at 40, b.i.d or EOD.

#646

First thing, there is training involved, and need to serious sterility including what is being injected and sterilizing the skin. I prefer 2% chlorhexidine at a minimum.
Now in regard to not being able to do it … EMLA is over the counter. You can get this, and under occlusion for 45 minutes (can use glad wrap) will get some reasonable anesthesia. Many of my patients use this for blood draws, but it works for lot of other things too.

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#648

Is that rap? Taylor Swift? You probably get exposed to different types of music in your household.

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#649

OK, so its morning and everything back to normal. Feel relatively good, or tad better than usual. Tinnitus returned unfortunately. Less stiff than other mornings generally speaking, not much else in terms of positives that I can report. So much for peptide euphoria from my original posting. :joy::joy:

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#650

Darn on the tinnitus returning. I was almost ready to share that with my poor brother.

Thx for the update.

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#651

I think that one may still a ways off from understanding how to use it for that purpose. Here is an article from 2011 that shows promise and research has continued but why is it not yet on the market? after 13 years?

Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice

https://www.pnas.org/doi/10.1073/pnas.1104540108

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#652

I… can’t … even … - gonna have to put me to sleep for one like that!!!

#653

“Since we’re all in the experimental phase, I think that I’ll try IM for the SS-31. The dose is said to be as effective at 4 mg as at 40, b.i.d or EOD”.

Withe the price of SS-31, there is sure a need for higher effectiveness! Do you have a source for that 10-fold increase for IM?

The two clinical trials I could find on SS-31 used 24 respectively 36 weeks of 40 mg/6d… I assume you are not aiming for that length of time…

#654

Could you share your supplier of the nasal bromentane? Would like to have it on hand when starting BR-157 for a persistent injury.

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#655

I use everychem. It’s owned by the fellow being interviewed here. He’s serious about quality and regularly reduces prices as he brings costs down. He’s behind r/NooTopics on reddit.

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#656

Has anybody experienced anything positive in a sustained way from SS-31/elamipretide? I hope so and that I can be proved wrong in my rather bleak view of this peptide.

Sadly, all the excitement and wealth of promising preclinical data for SS-31 does not seem to readily translate to humans in the few clinical trials done, on patients with mitochondrial disease.

A phase-3 RCT from 2023 with 109 patients in each arm used 40 mg SS-31 SubQ / day for 24 weeks and this was found to not improve outcomes in patients with mitochondrial myopathy. Efficacy and Safety of Elamipretide (SS-31) in Individuals With Primary Mitochondrial Myopathy | Neurology

A phase 2/3 **RCT from 2021 with 40 mg/day SubQ/d for 12 weeks likewise showed no significant effect. A subgroup of eight patients completed a 36-week open-label extension with the same dose, and then improvements were seen. “This delayed effect may be because it takes a significant period of time for skeletal and cardiac muscle remodeling to occur prior to observing measurable benefit"
A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism - Genetics in Medicine

(Assuming doubled bioavailability of IM, 48 weeks of daily 20 mg IM injections costs over 30 000 euro if purchased in this part of the world).

A phase 1/2 RCT from 2018 using 35 mg Intravenous dose /d for five days (calculated for a 70 kg person) showed efficacy but the effect largely vanished two days later (“this could be the effect of the short half-life of the drug”). (Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy | Neurology

It seems that a large dose of SS-31 is needed for a very long time to possibly have an effect in persons with mitochondrial disease, with effects from shorter dosing being transient.

Could “normal” mitochondrial defects from aging in healthy people (with no fatigue) be more amenable to SS-31? FWIW, there are many anecdotal reports from peptide forums of persons without mitochondrial disease “feeling great” on SS-31, down to doses as low as 4 mg SubQ, with no hard data. Often it is people with fatigue saying they are better.

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#657

An intro to peptides and a guide to which should be used and in what order.

The speaker recommend starting with Thymosin Alpha 1 for the immune system.

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