#181

Completely agree about ME/CFS. It absolutely destroys your life.

I was unable to get a prescription for higher than 15mg compounded, so out of desperation, I have gone the GFJ route. So if we assume 15mg compounded = 5mg bioavail formulation, and then use GFJ (ruby red) theoretically it will get me back up to 15mg bioavail equiv, maybe higher. This is super speculative, and I will certainly start tracking my blood levels going forward, I think next month.

I will say I feel great at this dose. Everything feels back to normal.

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#182

Do you feel great at 15 mg compounded and GFJ ? Why do you use compounded Rapa ? I use Rapamune solution from Pfizer which is pure Rapa (1mg/ml) and get peak values of > 60 ng/l with 14 mg without GF, but no relief from ME/CFS. Following your 45/35 mg indication I have now gone to 25 mg, but not yet measured pik values. I am curious to see you peak values at a dosing which makes you feel well. Blood pik value is best measured at 2.5 hrs after intake. Let me know and good luck.

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#183

Why nobody uses the standard Rapamune solution from Pfizer (1ng/ml) ? Isnt it available in US ?
It s pure Rapa and excellent bioavailability. At 14 mg dosing I got >60 ng/l pik, see my above post.

#184

Yes, I feel great at 15mg compounded and GFJ. The reason I got compounded is they (agelessRx) told me the 15mg compounded was equivalent to 12mg regular prescription, (and yet it was the price of a 5mg regular prescription.) Also, I used some of it for toothpaste, etc. Anyway, if its actually equivalent to 5mg, the cost argument no longer applies.

How severe is your CFS/ME?
is it post-infection? is it slow onset or fast? Do you also have an autoimmune disease? Have you ever been on a large dose of a corticosteroid while you’ve had CFS/ME?

#185

It’s more expensive than Indian generics.

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#186

FWIW I’ve assumed I’m a poor absorber of rapa via my many blood tests seeing sub 20 2hr post many times. After the kitchen sink of adjunavents, berberine, ALA, grape seed, peperine, powdered GFJ (no fruit or frozen near me) and 12mg have seen mid 20’s only once. 60 is crazy high (maybe good???).

FWIW I have always said everyone needs to blood test on the assumption that pre conditions, co-taken things affect absorbsion as body individuality.

Lifeextension no longer sells the sirolimus test. I had to call/go to labcorp.com and buy it direct. Still $99.

Of course no study confirming low blood level/ high blood level numbers for anti aging effect… ;( So no idea if 60 too high or my 20ish is enough…

Best to all, curt

#187

Hi Curt,

Unless it has changed, Gethealthspan.com offers the test, through Quest, for $25.

I’m also a poor absorber, fwiw.