Hi Patty. I was on the PEARL trial like you. Are you still getting the compounded Rapamycin? I see they’re not offering it on their website. Only the generic.
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Pattyg
#65
I am I just got my next months of pills in the mail?
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You’re still getting compounded? Have you noticed any changes with the compounded?
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Pattyg
#67
Unsure of what you are asking? I can’t say I looked closely at the bottle to tell if it was the same pharmacy. Just received my third bottle the first was 4 pills of 5 mg, now they are shipping monthly 4 pills of 10 mg. I have to admit I have had absolutely no side effects. I actually had more side effects from the placebo😳
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I am on the generic with no side effects. Can’t tell any benefits yet. Probably too soon. I was asking if you’re still getting the compounded and it sounds like you are. Could be the 10 mg is same as 5 mg generic since compounded availability is less.
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No - Ageless RX does testing on the compounded product so they know its bioavailable. See these posts / threads:
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Neo
#70
Anyone know anything more about the trial results?
Or what the gender specific effects might be?
I saw that this title is being presented at Raad:
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The last thing I heard from AgelessRx around the publishing the results is that it will be done in the end of July. So very soon. I have booked a podcast interview with Sajad in the middle of September in which we are going to go talk about the result in this important trial 
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I am newer to rapamycin dosing and am trying to learn why you would use GFJ. GFJ contains furanocoumarins that cause irreversible inhibition of CYP3A4. This inhibition leads to the inactivation and degradation of the CYP3A4 enzyme. New CYP3A4 enzymes must be synthesized to replace the inactivated ones, which can take several days. This being the case this is not pulsing rapamycin with the conventional half-life and/or strength, but something potentially much longer/stronger. Clearly you are doing this to increase the peak, but what about duration? Are you dosing weekly (bi-weekly?) when you do this and do your serum levels go back to non-detectable levels before dosing again? I would think piperine would be preferable as it does not permanently inactivate the existing enzymes and the inhibitory effect lasts only as long as piperine is present in the system, typically several hours.
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Welcome to the forum.
“The target sirolimus area under the concentration curve (AUC) of 3810 ng-hr/ml was achieved at sirolimus doses of 90 mg, 16 mg, and 25 mg in the sirolimus alone, sirolimus plus ketoconazole, and sirolimus plus grapefruit juice studies, respectively. Ketoconazole and grapefruit juice increased sirolimus AUC approximately 500% and 350%, respectively.”
The use of grapefruit or grapefruit juice has been discussed extensively in several threads.
“Phase 1 Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients - PMC”
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Hello C.
Good question - a few answers. I began my first year taking 3 pills of rapamycin/sirolimus 2 mg each.
This 6 mg dose (nothing else) gave many good health benefits increased strength, fixed my dysphagia, allergies relieved and a lot more. It was working great. Then hearing from a researcher - Mikhail Blagosklonny to go as high as possible without side effects. I was using the juice of one red grapefruit to increase my dose 3.5 to 6 times with 8 mg ( 4 pills of 2 mg each). So a way to get the highest dose and save on the pills . Because I was testing regularly using Labcorp, I knew I was at least getting the 3.5 increase. I did this for 7 months - thinking more was better. For me that was not true. The biological marker benefits that I got on one year use at 6 mg was negated drastically. Cutting my dose back down to 6 mg to 8 mg weekly the bio-markers returned to the good numbers after 8 months.
I have since decided to go strictly 4 mg - 2 pills of 2 mg with nothing. I will retest in 4 months.
In all medications - dosage is critical… too little nothing occurs… to much it becomes toxic. Looking for the middle - just right.
Having now been middle 6-8 mg and high approximatley 32 mg. Lots of cleaning and work has occured. Great benefits on inflammation reduction, skin quality improvements, dental great, memory off the charts, allergies gone… strong immune system.
Perhaps now a lower maintenance dose is in order 4 mg with nothing - will test in 4 months. It is all guess work… and each person responds a bit differently in benefits and side effect.
I hope this is helpful. I think as a general rule 6 mg weekly is good on average.
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JDK
#76
any news? Been waiting to see this one 
Jonas
#77
How much an improvement from baseline that you estimate you have had as you could have been very healthy to begin with? What other top supplements you are taking that may have contributed the positive outcome?
Same here, wondering why it is so quiet regarding the unblinding of PEARL trial? Not a beep from anywhere that I know of.
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@JDK and @Jonas In the webinar AgelessRx hosted yesterday they said that 27th of August 1pm EST they will share the PEARL trial data. Here is also one X post confirming that.
Source: x.com
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Jonas
#79
Good stuff Krister! Very excited to hear. Is there a link for the event?
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There will come a link. I have asked for it as well. Will post it here when it comes.
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The actual link to the zoom seminar registration page:
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When we get to see the results it feels like it’s first page news on Rapamycin.news 
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