#41

Furthermore, to your point, ferroptosis is a relatively new discovery on cancer cell self destruction. Both cysteine and methionine interfere with this process and are cancer promoting.
Glycine can counter methionine. I avoid NAC.

Researchers leverage cell self-destruction to treat brain tumors – ScienceDaily

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#42

Thank you for the detailed reply, good observations. I agree with you that the mouse study I linked is quite an extreme example of Rapamycin dosing. Still it is interesting to see what happens in that case. I also found it interesting that the Rapamycin feed mice ate more but weighed less. I wonder if the extra lipids are eventually dumped into the bile for excretion because they do not seem to go into fat. i.e. where does all the extra energy go? respiration perhaps? They do mention that glucose is spilled into the urine.
The overeating male mice also makes me wonder if people taking rapamycin are unknowingly eating more - in turn raising their glucose levels, even though they lose weight.

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#43

Hahaha…I can vouch that I eat constantly… and despite this behavior over the past 2-years stay at the 180 to 182 pounds range.

After my blood test… I had to do a fasting for 12 hours… for cholesterol test…I went immediately to have a farmers breakfast… bacon, eggs, pancakes, hash browns and toast.

My wife’s comment is you never miss a meal… nope I don’t. Hungry all the time.

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#44

I’d concur with that, ravenous when on Rapamycin but not gaining any weight no matter how much I ate. Also wasn’t on any T2D type drugs and my blood sugar levels didn’t appear to move either.
Currently I’m not taking Rapa - after about 3 weeks of being off it, weight started going up (put on 3Kg in one week) and had to hold myself back to make sure I didn’t put on more. Now after 8 weeks, no longer ravenous and can actually feel full. I’m now eating noticeably less. Have also lost the 3extra kg over last fortnight.
The other thing I’ve noticed is that I’m feeling much stiffer again when I wake up in the morning, just like before I started taking Rapa.
Haven’t lost any strength though (actually did a new bench press personal best last week).

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#45

Interesting. It makes logical sense to be hungry if the cells think they are starving. I do not know how this works mechanistically, but they must release some signal. The question is where does the extra energy go? I imagine it ends up as lipids after the liver converts the extra blood glucose and then is excreted in the bile. I have read that the liver makes up to one liter of bile per day from cholesterol, most of which is reabsorbed in the intestines. Does anyone know?

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#46

If floating excrement in the toilet bowl (I often see it) is a sign of a high fat content this is potentially the answer.

#47

Rapamycin seems to have a profound effect on weight gain. I have been taking a break from rapamycin for ~3 months to get my blood markers back in bounds and I have noticed a steady weight gain since I stopped. In 3 months I gained 6 lbs without any subjective change in my diet. My last bloodwork has everything back within the “normal” boundaries as defined by Quest Diagnostics. I will start rapamycin again on Monday and get blood tests more often so that I can adjust my dosage to keep everything close to normal.

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#48

I noticed the same about weight. No matter how much I eat, I cannot gain even a single pound. My usual breaks are only 2 weeks. Need a longer break from it, however it could be risky in my situation with transplanted kidney.

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#49

Funnily enough, just back from 4 days in Berlin, and not having control over the diet, that 3KG has gone back on again.
Fasting for 42hrs from yesterday into tomorrow which will take 2 of those 3KG away - luckily my IL-6 and TNFalpha have gone back to normal, so I’ll be starting back on the Rapa next week by which time I should have lost the remaining 1KG. (Aim is start back on the Rapa at the weight where I went off it).

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#50

Apparently this is Peter’s take as well.

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#51

Did you initially lose weight on Rapa and during your break gain it back or was this incremental weight gain?

#52

How often do you test TNFalpha? How good of a test is it and helpful do you find it?

#53

It is my understanding that PA is not accepting new patients, though I speculate that he perhaps would make an exception for some special reason.

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#54

The link below is his web site for the Medical Practice.

You make an application to be his patient.

I do not know what his current fee is for 2023.

In 2021/2022 his consultation fee was $157,500*{this was the amount reported/quoted to a member of this forum who applied] for 12 months, not including any testing, medications, etc, this was just for his consultation time, payment for 12 months. It is not pay as you go, all out of pocket cost.

Most people do not have the re$ource$.

*Yes, the cost reported/quoted was $157,500.00 for 12 months just for consultation time.

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#55

I was trying to reach 175 lbs, but I seemed to have plateaued at ~180 lbs and I was really having to watch my diet to stay at that level. After a few months on rapamycin my weight dropped to ~173 lbs and I noticed that then I could eat anything and maintain my weight. I will be making the same journey again starting Monday and see if I get the same result.

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#56

It’s something my doctor wanted to test. I’ll ask him specifically why next time I speak to him.
We still haven’t worked out why it became elevated - one of three possible reasons, and now it has come down only one can be ruled out (a completely different blood test next week to see if I have rheumatoid arthritis). The other two possibilities were a completely asymptomatic infection, or an ongoing asymptomatic reaction to a vaccination that I’d had 4 weeks earlier.
Interestingly, both have come down to levels below my pre-Rapa tests.
If my immune system was fighting off something, I’m very happy that it was doing it asymptomatically. I’m not sure that would have happened in my pre-Rapa days - I used to catch everything going and really suffer.

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#57

Yes, but the amounts in many supplements are much higher than can be obtained from the diet — and many “dietary” supplements are of natural products and molecules that are never part of the normal diet (side of grilled Bacopa, anyone?). St. John’s Wort for instance is notorious for interfering with the metabolism of many drugs.

The problems with such a simple-sounding solution include:

  • that many people will be on additional drugs and supplements other than these three, and each time you add a new one you increase the odds that something in the mix will interact with something else;
  • situations where A affects B which is irrelevant to A or B’s action but causes a problem if you then introduce C;
  • that there aren’t enough data on specific interactions amongst specific drugs;
  • that rapamycin has mostly been studied in transplant patients who are already taking other drugs, and who have medical conditions that most people taking it as an anti-aging drug don’t have, making it dicey to extrapolate;
  • that lots of interactions will take a long time to discover because few people take the two agents together
  • biochemical individuality

Note the phrase “digital program.” This is not a way to sign up as a patient; it’s a way to get guided videos and virtual worksheets and such that resembles being a patient in how you’re guided but doesn’t involve one-to-one physician counseling.

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#58

Thanks. I’m trying to figure out what should be in my testing to best evaluate inflammation levels besides hs-CRP.

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#59

first line tests are erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) (both CRP and hsCRP) and plasma viscosity (PV)… if you want to look more deeply, there are specific markers for specific conditions. You can look into specific cytokines, do the cytokine blood panel or just Interleukin-6 (IL-6) test, which is involved in chronic infections, autoimmune disorders, certain cancers and Alzheimer’s and can also be a marker for ASCVD risk…

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#60

Thanks which would you say are the most sensitivity / earliest to show any inflammation?

My hs-CRP is always bottomed out.