#21

It’s worms, C. Elegans.

2 Likes
#22

oops, yeah that’s dumber yet. Not as expensive though.

1 Like
#23

Yes, if we’re sure that what doesn’t work on C. elegans won’t work on humans, then we can screen thousands of compounds on worms (that’s their goal: “assess 1,000,000 longevity interventions in 5 years”) and move the successful ones to rodents and then… dogs? and then humans?

3 Likes
#24

@DeStrider I don’t think we can say that.

Perhaps one can say that that will be the case of lot of the time, but there are probably a lot of things that could help humans even if they won’t help worms.

2 Likes
#25

Things that are toxins for worms are most likely toxic for people.

As for compounds that have no effect, I think you are correct that some, like cholesterol lowering drugs, may have no benefits for worms but are useful for humans.

2 Likes
#26

Opposite view: Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis 2023

“The lipid-lowering variants of HMGCR, PCKS9, LPL, and APOB were associated with longer lifespans but did not causally increase extreme longevity. No statistical evidence was detected to support an association between NPC1L1 and lifespan.”

But contrary to the other MR study above, they didn’t look at sex differences. If Ezetimibe has any effect, it might be on males only. I’ll contact Ora Biomedical to see if we can try BA+EZE…

3 Likes
#27

Ora Biomedical’s answer about compounds not listed yet on their website such as semaglutide, selegiline or Urolithin A:

It looks like the requested small molecules are not in our sponsorship drug library. It would still be possible to sponsor these intervention tests through a custom contract. Purchasing and shipping compounds from a reputable research chemical supplier would be part of the sponsorship charge since we do not currently have the compounds in stock. We also recommend testing compounds across a dose response with these contracts.

So basically instead of paying $100 you pay drug cost + 3 x $100 (three different doses).

I don’t get why they need 3 doses for these and not for the ones listed. I’ll ask…

In the meantime, I’ve already sponsored:

  • Canagliflozin
  • Dapagliflozin
  • Empagliflozin
  • Telmisartan
  • Ezetimibe
10 Likes
#28

@adssx Thanks for sponsoring these. Those are all great choices. I’m interested in the results! Please post them here when you get them. :slight_smile:

3 Likes
#29

Thanks. They told me my results are expected in 6 weeks. I’ll post them here of course :slight_smile:

8 Likes
#30

BTW, do we have any results yet?

From what I see, many people here sponsored some interventions - how long it takes to get results?

1 Like
#31

6 weeks: Ora Biomedical launches crowdfunding of Million Molecule Challenge - #79

#32

I sponsored a random drug in October and haven’t heard anything

1 Like
#33

Weird. You should email them.

#34

I haven’t heard back either, and I paid back in November.

Screenshot_2024-03-04-18-14-35-13_40deb401b9ffe8e1df2f1cc5ba480b12
Screenshot_2024-03-04-18-14-35-13_40deb401b9ffe8e1df2f1cc5ba480b121080×2412 188 KB

1 Like
#35

You may have found the cure of ageing! :stuck_out_tongue_closed_eyes:

On Feb 7th the CEO emailed me: “We will start your experiment within 1-2 weeks (most likely next week) and the experiment will run for four weeks, so be looking out for your data report in about six weeks.”

5 Likes
#36

I think i read somewhere the public ranking list of tried compounds leaderboard was coming end of February. Think its soon?

2 Likes
#37

The results of the random test I sponsored have arrived, I share the results.

Order-8594_Azelnidipine_report_final.pdf (399.2 KB)

It’s funny that the compound I sponsored still appears on the list.

image
image1559×987 55.3 KB

7 Likes
#38

Here are some drugs that seem promising. Please look into them, and if they impress you, think about sponsoring them.

  • Bisphosphonates (alendronate sodium)
  • PDE4 inhibitors (roflumilast/ibudilast)
  • Bardoxolone methyl
  • Vorinostat
  • Marimastat
  • Decitabine
  • ORY-1001
3 Likes
#39

Thanks for sharing it!

So you increased lifespan but it’s not statistically significant? I wanted to sponsor amlodipine or lercanidipine in the same family.

I also had to email them about my compound still being on the list…

5 Likes
#40

BTW, can dose for testing here be chosen or does it automatically choose?

I think testing a few times may be because of different dosing - drug may work better / worse in different dose

Also, control group here appears to be quite short-lived (13 days) - so worms there probably aren’t stored in the most optimal conditions - maybe temperature was too high - worms live longer in lower temperatures

2 Likes