That’s great. And both were inline with other surrounding datapoint (and not just that you eg had an infection close to the first test but not second test)?

What else could it have been - did you change visceral fat / overall fat levels? I recall you also changed/increases some of your excessive regime?

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Yes - normal health in both cases. I have ramped up my exercise program to about 1 hour +, 4 or 5 times a week. I’ve done this for the past 3 or 4 months - so that might have had an effect.

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My CRP fell from 1.6 to 0.25 over a 9-month period. I believe the main contributors were starting ashwagandha 900 mg, quercetin 500 mg, and astaxanthin 24 mg. All of these have some studies reporting CRP lowering benefits.

My CRP actually rose a bit over my first 8 months of rapamycin. So, there hasn’t been any clear sign it is helping in that regard for me, but I am still taking it.

Ezetimibe did nothing to me and research shows it does nothing for hsCRP (the first post was incorrect and I fixed it). So ashwagandha might be the cause. How much do you take? Any thoughts on ashwagandha @John_Hemming?

I personally have tried aswaghandha twice. The first time was well before I really understood what was going on and I did not conclude it helped. The second time it made me ill (one of only two substances to do that the other being PQQ which was probably an interreaction with alcohol).

There is an Indian MD who campaigns against it because it can cause liver disease (which is true).

I don’t understand how it does any good if it does. It may do some good, but as a general principle I recommend against using it. I do maintain an open mind and if there was good evidence to take it then I would consider it.

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Same for me. My hsCRP was going down slowly but went below 1 with rosuvastatin 20mg.
Ezetimibe and Empagliflozin did not improve that further but Tirzepatide did and at 0.29 it was improved by a factor of more than 10 compared to the bad state I started.
Obviously Covid increased it but it’s still below 1.

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I take 2 capsules (1,000mg total) every day of this product: https://www.costco.com/youtheory-ashwagandha-1000-mg%2C-180-vegetarian-capsules.product.4000181013.html

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