The first thing to understand is that not everything that is identified through a genetic test comes to pass. For instance, 23andMe told me that I would have full lush hair and would not go bald.
However, my head has been disagreeing with that assessment! 
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DeStrider is right. You can have a variant association, but it only kicks in if you have same other variant also present, or do not have some additional variant that countermands the deleterious variant and so on. Single variants that are decisive are rare, and usually well documented. Otherwise you are looking at GWAS like at badger entrails, trying to divine what it means for outcomes, since epigenetics enters, enviromental triggers and protectors and so on. Frankly it’s a crapshoot. I had 23andme back in the day when they’d actually generate data for you telling you that you have this much higher/lower risk of this or that condition. But because it had such poor predictive power, and lack of FDA clearance, they stopped doing it altogether.
So, I’d treat that as mostly entertainment and not attach too much importance to it (unless it’s one of those slam dunk single gene conditions). You might keep an eye on it, but I wouldn’t stress. Back in the day, 23andme, showed that I had some ungodly high risk of prostate cancer; coincidentally, I just had a PSA test come back 7.49 and it scared the bejesus out of me. I had an immediate retest, and it came back 0.9, and ever since it stayed at or below 1, with maybe once or twice at 1.1 (I since traced that one time high PSA reading as likely due to a 5 hour bike ride I took the day before the test, lol). And elsewhere I linked to the Swedish study which showed that if by age 60, your PSA is at or below 1, your odds of dying from PC by age 85, are vanishingly small - so I no longer stress over my prostate.
Bottom line, don’t reorganize your life around that one variant, keep an eye on it, do the low hanging fruit in the prevention department and don’t stress excessively, unless you get concerning confirmations from other sources like biomarkers, family history and the like. YMMV.
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Bicep
#64
You can google scholar photobiomodulation and melatonin and you will find NIR light stimulates production of melatonin. Spending time outside in early morning and late evening gets you NIR since most UV doesn’t make it through the atmosphere sideways. Unfortunately UVA is the first and worst, but we’re built to take it anyway.
You can buy a NIR light and stand or sit in front of it, but they’re expensive and it always seems like a waste of time.
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As NIR reflects from green plants and trees its a walk in the park to get some NIR.
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This guy is the bomb for vit D and sunlight for health. He is the guy who discovered the active form of vit d. He is also entertaining.
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Thank you for the recommendations. I am trying to understand if people with fewer levels of melatonin receptors (MTNRant 1A variant), reduced expression of melatonin receptors will respond beneficially to a higher dosage of melatonin or possibly more melatonin may have a negative effect.
I dont know. When you get to say 0.5g probably all receptors are saturated. The mtDNA protection is via an antioxidant effect.
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Bicep
#69
I read his excellent book years ago. I’m a big fan.
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