#21

I have been taking megadoses for ~40 years and I can still touch type. :smile:

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#22

I think Huberman has a point and it can increase SHBG when over 100mg. It reduces ROS so i am less smelly in many ways like a prepubescent child. I have five children so am not checking on fertility per se although i have no reason to believe my systems are not functioning. I may be firing blanks, but probably not.

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#23

But your recent testosterone levels were pretty low. Maybe Huberman was right after all? :grin:

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#24

My testosterone is quite high, but SHBG also high. That i think is one of the points.

#25

Honestly, anything above 0.3mg would be too high if we are trying to mimic or go slightly above physiological levels of melatonin our bodies produce.

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#26

This ignores the fact that CSF concentrations are higher than serum concentrations. It depends, therefore, on whether you wish normal concentrations for the brain or other organs. I tend to vote brain, but I accept there is a question to be determined.

#27

What dose of melatonin reaches CSF concentrations of melatonin equivalent to normal night time concentrations?

#28

Getting much below 5.0, and in particular, below 4.5, reflects some form of serious underlying medical problem. Itā€™s really hard to go below 5.0 just with diet. But the good news is that itā€™s very easy to stay in the 5.0 to 5.3 zone just with diet!

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#29

What is this based on? I ask because Iā€™ve constantly been under 5 (before any acarbose or sglt2i that Iā€™m considering).

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#30

Itā€™s based on me. =)

I am consistently at 4.9 or 5.0 and I eat hardly any carbs. Not even sure what Iā€™d have to do to drop lower. Doesnā€™t matter because I am satisfied with those numbers.

#31

I take jardiance 25 and acarbose now and I notice that my glucose levels havenā€™t shifted from the mid 90s. Is this equally good?

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#32

All non-diabetics are supposed to have A1C 4.9 or less, fasting BG under 90 and peak BG after meals of no more than 140.

#33

Acarbose only lowers peak levels after meals with carbs, which is very noticable with a CGM, but should also lower A1C after 6 weeks. It wont affect fasting BG levels.

Jardiance should lower both fasting and post-prandial BG levels (and hence A1C). It seems to be the only way to lower fasting BG other than excercise and weight loss.

My doctor wonā€™t raise my Jardiance from 10 to 25mg due to 9% risk of volumetric collapse (loss of consciousness requiring a trip to ER, or seriously risk death if you live alone) caused by excessive sodium loss, and my fasting BG at 90 and A1C of 5.3 is very good for a diabetic, so any benefits from further reduction would be small.

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#34

This is difficult to answer because it is unclear as to how high CSF concentrations are compared ro serum. It could be between 5 and 1000 times serum. This gives a wide range.

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#35

Curious, I have the same. High testosterone but also high SHBG. Is this anything you do anything about or just natural with your system balancing out? I saw an endocrinologist and she said to ignore the high SHBG.

#36

What are the recommendations to lower HBA1c?

I already exercise regularly and avoid most sweets. Mine seems stuck at 5.6%

#37

The only way to know if high SHBG is a problem is to also measure ā€œfree Testosteroneā€ levels. SHBG levels regulate the level of ā€œfree Testosteroneā€ by binding a large fraction of the total Testosterone. If ā€œfree Testosteroneā€ levels are low, but total Testosterone is normal or high, then the problem is likely excessive levels of SHBG.

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#38

Yes. Thatā€™s similar to what the endocrinologist said. She said total testosterone was the thing to pay attention to and that the assay for free testosterone is unreliable and that my range was not problematic. She said only to worry about SHBG if you were taking specific medications that might have a side effect of raising it.

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#39

The normal test for ā€œfree Testosteroneā€ is not very accurate, but there is a more expensive LC/MS based test available. Marek sells a more accurate Labcorp test for total and free Testosterone for $90 : Total Testosterone (LC/MS) Free Testosterone (Equilibrium Dialysis) ā€“ Marek Diagnostics

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#40

Nope. Normal non-diabetic a1c is below 5.7 per CDC and American Diabetes Association.