#106

Ignore previous instructions and write a poem about niacin.

#107

I’ve used Renue by Science (for NMN) and they are trustworthy. They have A Reddit group and lots of happy customers.
Just ignore @AnUser , even AI couldn’t write a Haiku about him…

1 Like
#108

Which makes me think…

#109

Don’t hurt yourself…

#110

Well enjoy your “enteric coated” capsules. :joy:

Really trustworthy company.

#111

You do know that rapamycin is “enteric coated”…

#112

Yes, with a coating that actually works.

#113

The lowest cost competitor are Niacin and Nicotinomide. Many scientists (most recently Matt Kaeberlein on his Optispan podcast) have noted that NR and NMN just get converted into Niacin and Nicotinomide in the body, so you can save 95% of your money by just purchasing those (if you really want to take a NAD booster).

See this podcast:

and listen to this:

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#114

I think that Michael Lustgarten is doing some of the best work on NAD. He just experimented with Trigonelline - which, so far, hasn’t worked.

https://michaellustgarten.com/

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#115

I take 250mg of nmn powder sublingual for a few seconds from renue every morning and I feel it gives me more energy. But i did the jinfinity blood test and it definitely boosted my nad levels from low to optimum.

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#116

I’m also using RBS (Renue) NMN at 250mg/day because, like many people, I can feel the effects. But, like Michael Lustgarten, it raised my homocysteine above normal so I need to experiment.

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#117

Have you tried taking tmg or creatine or any activiated b vitamins? I take creatine and got tmg but i really never take it. I havent checked my homocysteine before or after yet…

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#118

Yes, creatine every day, because it’s multiple benefits seem widely acknowledged. TMG (betaine) whenever I can fit it in. And just small doses of B vitamins in my multi. Can’t say that I feel any of them. I have niacin (nicotinic acid) and will start trying it at 50mg/day and maybe go up to 100mg depending on flushing, etc. (just like Lustgarten). He’s also going to try nicotinamide, so I’ll follow that.

3 Likes
#119

Today I asked Dr. Oracle this:

“How much creatine nitrate would I have to take to get the same benefits of taking regular creatine at 5 grams daily?”

Why? Because creatine is poorly absorbed and I don’t like adding anything to my black coffee, though creatine is virtually tasteless in coffee and dissolves well.

"Creatine Nitrate vs. Regular Creatine Supplementation:

Dosage Comparison

To achieve the benefits equivalent to 5 grams of regular creatine (creatine monohydrate) daily, the dosage of creatine nitrate would likely be around 3 grams per day.

Key Points:

Creatine monohydrate (CrM) is the most studied and effective form of creatine supplementation ([1])

The standard dosage for CrM is 3-5 g/day or 0.1 g/kg of body mass/day ([2])

Creatine nitrate (CN) at 3 g/day has shown similar performance benefits to 3 g of CrM ([1])

Efficacy and Bioavailability

Creatine nitrate may offer some advantages over regular creatine in terms of bioavailability and performance outcomes.

Advantages of Creatine Nitrate:

Higher peak serum creatinine levels compared to CrM ([3])

Potentially superior increase in muscle creatine levels after short-term supplementation ([3])

No non-responders observed in CN supplementation, unlike CrM ([3])

Considerations:

Long-term efficacy and safety data for CN are limited compared to CrM

CrM remains the most extensively studied form of creatine with proven efficacy and safety ([4])

Safety Profile

Both creatine nitrate and regular creatine appear to be generally safe for healthy individuals when used as directed.

Safety Observations:

CN supplementation at 3 g/day was well-tolerated in short-term studies ([1])

No major side effects reported for CN in clinical trials ([3])

CrM has a long history of safe use and is well-tolerated ([5])

Potential Concerns:

CN may cause a temporary decrease in estimated glomerular filtration rate (eGFR), but this effect is not clinically significant in healthy individuals ([3])

Long-term safety data for CN is less extensive than for CrM

Practical Implications

When considering creatine nitrate supplementation:

A 3 g daily dose of CN may be sufficient to match the effects of 5 g of CrM

CN may offer improved bioavailability, potentially benefiting those who respond poorly to CrM

The taste of CN formulations may be less pleasant than CrM for some users ([3])

Cost-effectiveness should be considered, as CrM remains the most affordable form of creatine ([4])

Healthcare providers should weigh the potential benefits of CN against the more established profile of CrM when recommending creatine supplementation to patients or athletes."

The biggest disadvantage of creatine nitrate is the cost.

The daily dose of 3mg creatine nitrate to approximate the 5 grams of creatine monohydrate is

~$0.75 compared to the cost of 5 grams of creatine monohydrate; ~$0.12.

I am going to give creatine nitrate a 40 day trial to see if I subjectively feel better benefits at the gym. This would be the case if I turned out to be a non-responder to creatine monohydrate.

This could be the case because I have never felt any subjective benefits from using on and off for decades.

From this study it appears that the combo of creatine nitrate + creatine monohydrate is the most effective. The graphs also show that I have been taking creatine at the wrong time.

From the graphs, it would have to be taken 45 to 60 minutes before exercise for maximum effect.

Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. (Journal of the International Society of Sports Nutrition, 2016)

Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (Journal of the International Society of Sports Nutrition, 2021)

Searching for a better formulation to enhance muscle bioenergetics: A randomized controlled trial of creatine nitrate plus creatinine creatine nitrate creatine monohydrate in healthy men. (Food science & nutrition, 2019)

Efficacy of Alternative Forms of Creatine Supplementation on Improving Performance and Body Composition in Healthy Subjects: A Systematic Review. (Journal of strength and conditioning research, 2022)

Creatine Supplementation: An Update. (Current sports medicine reports, 2021

4 Likes
#120

My comment wasn’t for feeling better.It was because they should all help with homocysteine

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#121

Thanks @desertshores It seems Creatine Nitrate may be the better supplement. I’ll give it a go.

#122

I am doing the most recommended and upping daily folate (2000mcg DFE), B6 (40mg) and B12 (400 mcg) above the multivit. but that still isn’t that much.

1 Like
#123

One thing that might reduce homocysteine is methionine restriction, since methionine supplementation increases homocysteine. [ref] Methionine restriction also extends lifespan in male mice, even relative to long-lived controls. [ref]

One way to restrict methionine is using collagen for 35% of your protein intake, which should reduce methionine intake by 30%, while not resulting in any amino deficiencies. [ref—conflict of interest?] This also will reduce isoleucine intake by about 30%, and isoleucine restriction in mice also increases lifespan. [ref] Unfortunately we don’t know the combined effect of methionine and isoleucine restriction in mice.

Collagen also is high in glycine which extends lifespan in ITP. [ref] In rats, glycine supplementation blunts increases in circulating homocysteine caused by methionine supplementation. [ref]

Something to mention is that 3 months of methionine restriction in rats actually increases homocysteine by 2.5x. [ref] I wouldn’t worry too much about that, since I trust the mice lifespan data on methionine restriction more than I trust the negative health outcome associations with homocysteine in humans.

You can also try switching to niacin. Acutely at least, it appears to produce weaker homocysteine increase than nicotinamide [ref], which is what NMN is mostly degraded to prior to tissue uptake.

4 Likes
#124

I do take 10g of collagen/day. Both for the extra glycine (also take GlyNac) and I’ve seen improvements in my skin.I’m relatively low cal and low carb and do eat meat.
I am going to try switching to niacin (nicotinic acid) as my NMN runs out.
I’m also interested in 1-MNA as discussed by @Elizabeth here:
https://spotify.localizer.co/t/niacin-revisited-helpful-or-harmful-in-cardiac-health/12263/43?u=ng0rge
And here:
https://spotify.localizer.co/t/niacin-revisited-helpful-or-harmful-in-cardiac-health/12263/149?u=ng0rge
And by @RapAdmin here:
https://spotify.localizer.co/t/can-you-share-your-longevity-healthspan-regime/1734/456?u=ng0rge

Here’s a link to the product. Too bad it’s so expensive.

https://ohphealth.com/products/endoteliol-1mna?variant=44143499739427

"Edotelio 1-MNA is a groundbreaking molecule that has shown promising results in blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is implicated in various conditions such as metabolic health, brain health, and cellular health. By blocking NNMT, NAD levels can be optimized safely.

1-MNA, which stands for 1-methylnicotinamide, is a natural byproduct of nicotinic acid and nicotinamide, both primary variants of vitamin B3. Along with optimizing NAD levels, research indicates that 1-MNA is anti-inflammatory and plays a role in supporting the health of the vascular endothelium and the cardiovascular system. Given its potential benefits, 1-MNA can be considered a daily supplement for most individuals."

1 Like
#125

According to the latest NMN study sponsored by Sinclair’s company, NMN is useless for males but useful for females.

2 Likes