I am less positive on both NMN and NAD. It’s a see-saw for me. The problem is that the research data is not incredibly strong, and NMN is relatively expensive. It seems that opinions about it change and are very dynamic. However, it seems like if it does have any benefits, they may be targeted towards my lifestyle which is a plus.
From my research, it appears that NAD levels decrease the most due to the SASP and cytokines that senescent cells inject into our blood. Therefore, the best way to increase NAD levels should be by reducing senescent cells or reducing SASP. For that, we have Rapamycin and Taurine for the former and Apigenin for the latter. Honestly, though, I can’t feel anything from Apigenin alone and will probably drop it when I run out in a few months.
If I continue down the NAD route, I think I will switch to NR or drop it altogether. The big reason I take NMN is for energy, healthspan, and overcoming jetlag (which it does amazingly well IMHO). I think I will need to stop NMN and monitor my energy levels. If I don’t feel as energetic, I may decide to continue with NMN (or NR) even though it may not do anything else for me. An energy boost is very important to me.
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Neo
#82
Thanks Chris. I’m going to test my levels and then take it from there.
Curious, in what way / timing to do you use it for avoiding jet lag?
As soon as I land in a new location (usually on the other side of the planet), I take it the following morning. It resets my clock and then the jetlag is gone so the adjustment is painless. Jetlag would affect me for 2-3 days in the past.
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