Nir Barzilai's ranked list of longevity compounds

[Krister_Kauppi]

@Deborah_Hall Thanks for sharing this! Curious, do you have any study or paper showing this? On bottom of page 4 in the following article he writes about bisphosphenates View of An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

@amuser Really great research summary on bisphosphenates! Did you take help of a GPT for this?

@John_Hemming Interesting, do you remember which paper it was?

@Steve_Combi Big thanks for sharing this! How much weight did you loss thanks to the GLP-1 R’s?

@约瑟夫_拉维尔: This reminds of this big human study on aspirin.

“Higher all-cause mortality was observed among apparently healthy older adults who received daily (low dose of) aspirin than among those who received placebo and was attributed primarily to cancer-related death.”
Source: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly - PubMed

Here is an article summarizing that study:
https://www.nia.nih.gov/news/daily-low-dose-aspirin-found-have-no-effect-healthy-lifespan-older-people

[Steve_Combi]

55 lb’s down from 195 to 140 - I varying from 140 to 143 depending on dietary choices

But I’m not concerned about weight anymore. Huge emotional weight lifted that I have endured for over 40 years. I consider GLP1-R’s to be a significant health span increasing intervention for other wise “healthy” people who are over weight and about to become truly unhealthy as they age.

GLP1-R’s provide both emotional and physical benefits.

[John_Hemming]

I don’t remember the paper, but I think it is was one of the key ones. In any event I think I have a full understanding of the mechanisms behind aging and metformin won’t make that much difference.

[LukeMV]

Here’s my list if I had to make an educated guess

1. Rapamycin (overall)
2. SGLT2 (T2D, cardiovascular, and kidney protection)
3. ARB/ACE (mostly due to BP lowering effect)
4. Statins/PCSK2 or whatever else lowers ApoB
5. GLP1 (at low doses IMO for longevity)
6. Acarbose
7. PDE-5
8. A well dosed multivitamin. Most aren’t good.
9. Taurine
10. Astaxanthin or Creatine

If I could rank bio identical hormones as a whole to prevent age related decline, that might be first though. There are just so many of them and not all are equally important.

Also tempting to put naproxen somewhere based on the UK Biobank study that got attention last year but we need way more data.

[Bicep]

Sulforaphane has pretty good evidence.

[Bicep]

Am I crazy here, I am starting to think the peptides are moving forward and nothing else is. They might go in there too, if we figure out how to manage them.

[qBx123Yk]

That is my impression as well, I’m very bullish on them lately

[LukeMV]

Ah kind of. I just want a little more evidence. I used to take sulforaphane but haven’t for a few years. It’s criminally understudied if you ask me.

Sulforaphane evidence in food is good though. Just not sure if it’s translates to supplements. I think about how spermidine has good evidence in food but the supplements pretty much did nothing.

[DeStrider]

Here’s my list based on what I know:

1. Bempedoic Acid+Ezetemibe+Statin - CVD is the #1 killer and you have to jump this hurdle first
2. Fixing Deficiencies (Vitamin D3, Omega 3s, B-12, Magnesium, and Creatine are most common)
3. Rapamycin + Acarbose/Metformin (It’s the combo that works) + lithium orotate
4. SGLT2i
5. Fixing Amino Acid Deficiencies (age 40+) (Taurine+GlyNAC)
6. ARB (Telmisartan for BP control and increasd insulin sensitivity)
7. GLP1 (if overweight)
8. PDE-5 (blood flow)
9. Astaxanthin (for males - ITP results)
10. Anything specific to your health condition (will vary by individual) (i.e. dutasteride for prostate cancer, etc…)
11. Assorted supplements (vitamin K, berberine, collagen, hyaluronic acid, TMG, spermidine, glucosamine, multivitamin, vitamin C, CoQ10, Citrulline, Turmeric, protein, ergothionene, iodine, galantamine, cacao)

[LukeMV]

Similar to my list but yours is more detailed

[amuser]

any ai will do.

@Krister_Kauppi

Did you take help of a GPT for this?

extra chars

[Jonas]

The bottom line per Nir: SGLT2 Inhibitors (12) and Metformin (11*) score highest, suggesting strong longevity potential. Rapamycin (11(9)) shows promise in lab studies but lacks human mortality data.

How could SGLT2 have the strongest data, given that it is relatively new (10 yrs or so)?

[Jonas]

Did Grok get it right?

[DeStrider]

That’s pretty good! SGLT2IS have more impact on various diseases and longevity than Grok mentions. Taurine also prevent formation of senescent cells. These are finer points, but Groks summary is better than mine.

[Joseph_Lavelle]

@Jonas

How could SGLT2 have the strongest data,

I wouldn’t ponder this simplistic scoring too deeply. It’s just intended to quickly identify the high potential items. It’s almost entirely subjective.

[Steve_Combi]

@LukeMV

Just not sure if it’s translates to supplements.

Our personal experience with sulphoraphane supplementation is quite amazing. I had read that it may help with Autism so I purchased some for our, at that time 4y/o autistic grandson. He is now 5.

He was non-verbal, no eye contact but was comfortable with a hug and a cuddle some are not.

Within a week of taking 400mcg of Swanson Sulphoraphane in his morning juice, he changed dramatically. Eye contact, all the time, saying one or two words.

A year later, full sentences, says his alphabets, knows all his dinos, fully engaged and looks you straight in the eye. He is a very kind little boy and treats his little 3 y/o sister very well, even when she causes him trouble, he does not retaliate. She is on the spectrum as well but not as bad at her age as he was.

He is still autistic as this is not a “cure” but it sure makes a difference. When he misses a dose you can see it the next day. If he takes too much, he becomes overly emotional (sad scenes really bother him) when he is watching his fav TV show.

Dose makes a difference for him. It’s quite amazing.

[LukeMV]

As far as I understand, a sulforaphane supplement must contain both glucoraphanin and myrosinase. I looked up the label for the Swanson brand and it’s unclear if it contains both.

Frontiers | Glucoraphanin conversion into sulforaphane and related compounds...

Last I checked, BROQ/protaphane and Avmacol (and perhaps Broccomax which is suspiciously cheap) are the only sulforaphane supplements that have both.

Since Broq is considered the gold standard but costs more than $1 per day to get a serving, I haven’t been taking it.

[Hackingbiology.com]

@Steve_Combi

I’ve been using Tirzepatide (Aug 2023) and now Retatrutide (Apr 2024) since August of 2023. Just over 18 months now

May i ask the sourcing for Retatrutide?

I didn’t managed to find out any commercial

Fabio

[johnhighsmith]

Agree. On the other hand, hip fractures result in significant morbidity and mortality in the elderly. As a dentist, my advice is to only use these if you either have no teeth or super healthy teeth. If you’re on a bisphosphonate, there’s a risk of non-healing. If you really need bone density support, I’d recommend either Forteo (not used much as it’s pricey and a daily injection) or Prolia, which only lasts about 6 months, so any oral surgery is safe if timed properly with the infusions. Floss!!

[Jay]

Deborah_Hall, Osteoporosis is one of the things I’m concerned about. I always thought an adequate diet and exercise would resolve any problems for me until I got an osteopenia report years ago. I’ve avoided the bisphosphenates for the reasons you cite and I’ve found no solutions other than continuing my diet + exercise routine. Have you done any research on HGH or peptides that increase HGH in connection with bone heatlh? I speak from ignorance, but I do wonder if low-dose HGH (or HGH promoting peptides) would improve bone density the way it would naturally take place.