FWIW (and you probably already know this), but Methylene Blue’s MAOI activity only significantly occurs at 1mg/kg doses. It’s also a reversible inhibitor, so the effect is quite transient. I would imagine that doses < 0.5mg/kg would be quite safe even with SSRIs. Not that I’m suggesting you change your protocol - serotonin syndrome is quite serious and it’s probably not worth even trialing Methylene Blue even if the risk is very low.
@dicarlo2 I agree with you on this, but need to be cautious with what I advise, especially as a lot of the care I give is a little bit different than standard allopathic medicine.
@adssx On the vitamin D we are left in a poor evidence zone, due to the research on interventions with vitamin D have almost uniformly been based on giving 800-2000 IU BUT not measuring blood levels in response. From TargetD Study we certainly saw the range of doses required to treat those who were deficient - and their goal was just to 40 ng/mL, I believe. Some 13% required >10,000 IU/day to achieve this. We need more data as this fairly simple issue still doesn’t have a good trial to my knowledge where supplementation is checked with blood levels and given to a certain target.
I’m comfortable on the safety of running this in the higher ranges, but I cannot point you to any appropriate research that supports better outcomes with higher Vitamin D. We plainly don’t have the data in the format, to my knowledge. There are a few studies that seem to indicate higher levels = better outcomes, but nothing that is definitive.
2 Likes
I think higher serum levels of 25OHD are good, but depending upon the individual higher levels of cholecalciferol are harmful. This fits with the papers I have read. Ones which give a large dose of cholecalciferol once a month find lower benefits or no benefit.
2 Likes
amuser
#164
7 Likes
medaura
#165
It goes without saying everything on this thread is entertained as potentially preventative, not curative.
I’m on vacation with kids and on the go so not ideally situated to pull the research together but I strongly urge you to Google each compound along with Alzheimer’s and Google’s new AI will pull the relevant information along with the studies at the very top. HMB seems very promising and my intuition tells me that somehow muscle preservation / performance is connected along certain pathways to brain health so it doesn’t sound surprising.
The real shocker to me was intranasal rifampicin (with resveratrol boosting effectiveness). All I can say is look it up to see for yourself. I was blown away.
Trehalose you already seem to know something about. There might be additional longevity effects from its functions on mitochondria.
2 Likes
Looking at the commentary the research looked at people who were prescribed 1,25 di hydroxy vitamin d who are often people with kidney failure. Hence it was flawed in being reported as supplementation of cholecalciferol
2 Likes
Damn. I never heard of this risk but sure enough trouble falling and staying asleep is a known side effect of higher dosing of vitamin D supplementation and taking vitamin d at night. I’m backing down from 10k EOD starting tomorrow.
Thanks again.
4 Likes
Josh
#168
I take vitamin d in the mornings because if its supposed to be sun that is best in the mornings instead of night. But i think the half life is actually high? 2 to 3 weeks or 15 hours depending on form. Might not make a difference then.
2 Likes
If you take 25ohd itself this problem does not arise. I use dedrogyl. Somewhat stupidly it is a prescription molecule in the uk. I take about 20 drops a week.
2 Likes
It is worth understanding the way d3 is metabolised. The molecule we eat or is created from UV is called cholecalciferol. The liver converts this to 25ohd (Calcifediol) which the body stores. The body uses 1,25 di hydroxy vitamin d (Calcitriol) which is made by the kidneys from 25ohd (Calcifediol) on demand.
4 Likes
adssx
#171
Thanks a lot! This paper is shit indeed. The others remain though: high serum vitamin D seems associated with more and not less dementia past a certain point.
If you have a list of the papers we could try to isolate the effects of cholecalciferol from calcifediol.
Anyone know how to source in the US?
dedrogyl… calcifediol
Try goldpharma.com they may deliver.
2 Likes
RPS
#175
Supplementhub.co.uk claim to be selling Calcifediol
3 Likes
Brush with food grade tea tree oil. After a few months of using this, the inflammation around an inplant has cleared. I also use floss, a waterpik, xylitol gum but the tea tree oil has made the greatest difference.
2 Likes
Get rid of oxysterol. Cyclodextrin. Do that, and prevent AD and some other NDDs in ApoE4 folks.
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
2 Likes
AnUser
#178
No, you can’t determine what works to prevent AD and NDD based on in-vitro studies or animal studies.
1 Like
Here you go on this.
@adssx It’s interesting on the vitamin D. I’m not sure we really have the data, and as much as the Mendelian Randomization looks at who genetically might have high vitamin D or low vitamin D levels … did they actually have high or low levels? Given that this is substantially dependent on light exposure, skin color, and supplementation, things that don’t have a genetic basis (apart from skin color) I’d prefer to see data of long term vitamin D levels and then rate of disease.
I appreciate this data isn’t as readily available as it should be.
It is quite appropriate to have concerns about confounders with association studies. For much of what I’m recommending for AD it is the best information I have, and some will fall out, some will prove to be true. However, it is important to not cause harm and perhaps backing down to a goal level of 50 rather than 70-90 might be a good middle ground?
5 Likes
Thanks. That was the only one I could find and bought it despite the 1x/ week dosing. Hopefully that isn’t a problem.
1 Like
