#213

FWIW, I experienced no effect from up to 2g of sublingual NR and/or NMN. I did measure NAD through Jinfiniti and my levels were very high normal, so perhaps that’s why I didn’t notice anything.

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#214

While NR-recipients exhibited a slight initial rise in serum homocysteine levels, the integrity of the methyl donor pool remained intact

I am surprised they didn’t supplement with TMG especially with these super high doses.

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#215

I think that’s the KEY, I doubt that people with normal NAD levels can truly benefit from… more NAD.

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#216

I’m considering a 6 month blast of endogenous ketones but not sure what to “measure” before and after.

Also, a random thought… do exogenous ketones help eyes/optic nerve? That would be easy to test impact

#217

I’m not sure what to measure either. When it’s about cognitive performance I put a lot of stock on subjective measurement. In 2019 when I was full on keto and working out my mind was sharp as a diamond. I well remember that!

#218

Better than ketones in a bottle for sure. I went from full keto to low carbs but I’m staying in mild ketosis which I find to be enough to keep a sharp mind.
I also credit the SGLT2i (empagliflozin), and running, form helping with that.

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#219

I’m convinced that there is something here:

This is supposedly the sound used by the MIT researchers: https://www.youtube.com/watch?v=UVne_84qZkA&ab_channel=DJNizzo

Some members of the research team started a company to make a device that applies visual and audio stimulation based on their research: https://www.cognitotx.com/

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#220

I have the cheapy device that just synchronizes the sound from headphones and the flashes of a light strobe to 40 hz. It’s pretty simple. Less than $100 on Amazon and not unpleasant other than the whiteness of the light which I get around by wearing red light glasses in the evening anyway.

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#221

Could you post a link to this device, please? @medaura

#222

Here you go. Looks like it went down $10 since I bought it. It’s pretty cheaply made, incredible margins. But it does the trick. It definitely entrains that frequency as I keep hearing it in my head once I shut it off.

https://a.co/d/igtpzU9

Screen Shot 2025-03-28 at 5.28.35 PM
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#223

The 2 that we have are a little more pricey - but I’m also testing them for whether to recommend to patients.

The Koushicare - I like - here is a well done review on it.

The Symbyx Helmet is the other one we have (I’ve got a 5% of coupon if anyone wants this). Here is a great review from a patient with PD - but also should work for AD or MCI as should the Koushicare.

With each of these we’ve seen improved (substantially) sleep scores and specifically higher % of sleep in each of REM and Deep. Parkinson’s Patient talking about helmet. The physicians who did the phase II trial (phase III ongoing now) are here.

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#224

That’s great. Do any of the studies see that too?

How long and what time of day do you do it?

#225

I suspect there is some data on that - but right now a whole bunch of testimonials - and my wife and I have had consistent changes that only occur when we wear it prior to bed. We usually do the helmet M/W/F and add to that KoushiCare 30 minutes before bed, then last the vagus nerve stimulator. We saw most of the improvement with just the KoushiCare, the vagus nerve stimulator only adds a little - but we’ve not tried that as monotherapy.

Videos of note on the Symbyx are here:
https://symbyxbiome.com/blogs/symbyx-blog/5-years-of-continue-light-therapy-use-for-parkinsons-trial-results-now-published|

1 Like
#226
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Vaccines for longevity
#227

Why does the reviewer say Gamma Ray? I hope it’s not actual gamma rays :rofl: probably battery doesn’t have enough to juice to generate gamma rays anyway.

Isn’t this supposed be just very long wavelength infra-red light therapy ?

#228

I believe it is gamma radiation and penetrates about 3 cm beyond skull into brain is what Symbyx claims.

@desertshores Sorry for the misspeak. Hate when that happens - yes it is 40 hz frequency of light, and some devices add sound or vibration (the Koushicare has intermittent vibration). Yes the gamma waves are a frequency in the brain 30-100 hz and the best data looks like 40 hz helps the glymphatics - and it does seem to improve mitochondrial function in the brain, and at least on the symbyx helmet, their scientists believe it gets increased activity 3 cm below the skull.

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#229

This is very interesting. I was curious about the difference between men and women mentioned in that article but not specified, so I did some searching, and it seems according to the paper the overall reduction was 20%, but ladies who received the vaccine experienced a 31% relative reduction in dementia risk, while men saw a 6% reduction. Huge result then for women.

https://www.nature.com/articles/s41586-025-08800-x

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#230

I personally found NMN very useful for getting rid of jetlag when I fly from Hong Kong to the USA. It’s completely gone when I travel and use NMN. That in itself is amazing.

I also notice an energy bump. I mix the pure powder with EVOO in my morning shot (of EVOO).

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#231

No, no, no. Gamma radiation would be dangerous, and the rays would penetrate much deeper, and such a machine would be illegal for home use. It is the 809-900nm IR light wavelengths that penetrate ~3 cm into the skull.

We are actually talking about gamma brain waves.
“Gamma brainwaves, with frequencies between 30 and 100 Hz, are associated with heightened cognitive functions like focus, concentration, and memory, and are sometimes called “super-learning” waves.”

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#232

Ha, I did a double take too when I read, “gamma radiation.”