My 15.5 year old sweet golden doodle passed away last week

[AnUser]

@drfawn

Does it have to be a special type of capsule to get absorbed or resist acid breakdown?

@Davin8r

I don’t think anyone has found a capsule that will do it, but I’d search the forum for the discussions on the topic.

The problem is that the average gastric emptying time can be much longer than what the ‘acid resistant’ capsules are marketed to. So if the spec is at 1 hour, you’d want to take it on an empty stomach and drink water and do some light exercise to increase gastric emptying time.

Totally doable and makes powder usable, if it was real rapamycin without a bunch of impurities.
I wouldn’t take powder personally since I can’t verify whether it’s real.

[Davin8r]

@AnUser

Totally doable and makes powder usable,

Did anyone test blood levels after taking an acid resistant capsule + water?

[RapAdmin]

@drfawn

I feel that it must make it through my GI system in powder form, since when I raise the dose too much, I get diarrhea

There is a research paper on why higher doses of rapamycin cause diarrhea. And yes - some sort of good protective capsule is needed for rapamycin. Its hard to know what is working in a person, without blood tests to validate.

See this thread:

Why People Get Diarrhea When Taking High Doses of Rapamycin

The immunosuppressant rapamycin frequently causes noninfectious diarrhea in organ transplant recipients. We investigated the mechanisms of this process. Results Episodes of noninfectious diarrhea occurred in organ recipients after increases in serum levels of rapamycin. The expression of NHE3 was reduced in the ileal brush border of patients with diarrhea. In rats and mice, continuous administration of low doses of rapamycin reduced levels of NHE3 in intestinal tissues; this effect was not observed in mice with intestinal deletion of ATG7, indicating that autophagy is required for the reduction. Administration of single high doses of rapamycin to mice, to model the spikes in rapamycin levels that occur in patients with severe diarrheal episodes, resulted in reduced phosphorylation of S6 and AKT in ileal tissues, indicating inhibition of the mTOR complex (mTORC1 and mTORC2). The intestines of mice with intestine-specific deletion of mTOR were dilated and contained large amounts of liq…