#27

Chris Masterjohn gives a convincing reason why we shouldn’t waste our money on Urolithin A. You have to have a twitter profile to see the entire thread.

Chris Masterjohn on X: “THE CLAIM: Four months of Mitopure Urolithin A will boost your VO2max by 14.3%, your strength by 12%, and in just 8 weeks will boost your endurance by 17%, without doing any exercise! :thinking: Since four months of Mitopure costs $500, it’s worth taking a closer look at this claim. https://t.co/qX94D5emBl” / X

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The latest worm lifespan experiment：Urolithin A extended the lifespan of worms by 45%, surpassing other compounds such as rapamycin
#28

There are several brands of urolithin A in addition to Timeline. Any experience with the less expensive brands?

#29

I’m taking the capsules from get healthspan. It’s still expensive but definitely better than timeline, and I feel I can trust their quality.

Having said that, I’d love to find an even less expensive trustworthy option.

It was just last week someone here said they are sourcing it from Aeternum Urolithin A (UA) Powder – The Aeternum Company
They do 3rd party testing, so maybe this is a good source, too?
My only worry, for me, is that it’s a powder and I tend to be a baby about the taste of things.

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#30

I have seen urolithin A brands that are liposomal. What do you think about that?

#31

I am curious about liposomal supplements as well, but I don’t know enough about the topic. My number one would be if it’s a trustworthy brand and if the ingredient inside is actually UA. It’s the only reason I’m paying more at the moment, because I don’t know who to trust.

I did just buy two different supplements from Renue By Science in thinking that my gut is potentially not very good, so perhaps getting something that supposedly absorbs better was worth a shot. I hope others who are better informed chime in!

Edit: @Bruce4654 btw, I got 3 months worth at 20%, which makes them 54.66 per month. Also, I just noticed the brand that sells the powders also sells capsules with no fillers. I see each pill contains 500mg, so if this is a quality brand (I don’t know), their capsules become very affordable.

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#32

I have to admit that I take a lot of supplements and I don’t discriminate about various brands. I try to take liposomal versions for things like urolithin A and co-q 10. But I will look into Healthspan supplements. Thank you.

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#33

Addendum:
But I will say that my mainstay is a high-polyphenol, whole-plant food diet, including various mushrooms, seaweed, nuts and seeds, whole grains, beans and legumes, herbs and spices in addition to fruit and vegetables, including lots of cruciferous.

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#34

I eat similarly, but not nearly enough mushrooms and seaweed.

I’m less worried about brands for things we can measure for things like, let’s say, vitamin d… if there is no vit d in there, my labs will show it. I do follow the threads here on trustworthy brands and I try to mainly stick to those. I’ve seen the videos where they send things off for testing and there is zero active ingredients in the capsules.

After your post, I did some more searching and saw a couple of positive comments about the Aeternum brand, so I have asked my super brilliant friend if he thinks they are legit… if so, I’ll switch. I’m all about saving money when all else is equal! If you do get healthspan, definitely try to wait for one of their 20% off sales.

On liposomal…
I took a test and found out I was deficient in coq10… and because ubiquinol is supposedly more readily absorbed, I chose that. However, I did see a liposomal coq10 option and wondered if that made it equivalent to ubiquinol. Because you are taking liposomal coq10, I would love your thoughts, if you have any.

#35

I have to admit I am confused. But it’s not your fault. I just never gave much consideration to brands. I get the least expensive versions on Amazon or Vitacost brand. The co-q10 I take is Besibest brand. It’s liposomal 1000 mg of ubiquinol. I take for two days and take off one day. If I had to research every supplement brand I would go crazy. But you made me aware that I should do more research.
I do take a lot of plant powders that I mix together to make my own anti-oxidant and high-polyphenol drink. I know you said you are turned off to bad taste. But when I drink it, the bad taste lasts only a few seconds. So this homemade drink consists of spirulina, olive leaf, beets (not SuperBeets), avocado, kelp, macha green tea, black tea, Life Extension coffee, various mushroom powders, etc. Many can be purchased from Nuts.com which has more than just candy and nuts, or from Amazon.
I know I am lazy when it comes to researching the quality and reliability of supplements.

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#36

As an aside, did you know you can go to the Life Extension website and read their magazine as a pdf?

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#37

Just yesterday someone I respect here told me they take an olive leaf supplement… I had never heard of doing so… so see, you are doing much better than you give yourself credit for!

Coq10 vs ubiquinol IS confusing. I’ve gone round and round on this before!
Coq10 is called ubiquinone
Ubiquinol Is a reduced form of Coq10 and considered more bioavailable.

I definitely think you can make it easy and buy inexpensive supplements, but at the same time, the universal message that I see is be very very wary of anything sold on amazon. I will buy supplements on amazon if it’s from their ‘store’, but I no longer buy random brands from random places that I haven’t heard of.

To the best of my knowledge, vitacost is a quality company, but I have not heard about their house brand, but it might be good? iherb is also up there with vitacost and it was just within the past few days that people here were commenting that the iherb house brand is trusthworthy, so perhaps check them out.

NOW brand is universally loved and their prices are very good. That seems to be everyone’s go to. You mentioned life extension which is also seems to be a universally respected brand.

For powders people seem to like bulk supplements and pure bulk (but yeah, I have not bought the powders yet :)… on that note, and at your prompting, I might try it again. I now take a citrate powder mix, and mixing it in mango juice was recommended to me… makes it much better… so as long as I’m throwing back a quick shot while holding my nose, maybe I should consider adding some more things to it.

I checked out your ubiquinol. So, I gather you were looking for a vegan brand (I’m vegan and finding vegan ubiquinol is limiting). I’m finishing up my expensive bottle, and afterwards, I’m switching to the Healthy Origins Vegan option (they have a non vegan option, so pay attention) Ubiquinol (Vegan) 100 mg ( Active form of CoQ10) – Healthy Origins USA

I discovered them recently on a Ryker video (the anti aging YouTube channel) where he goes over the various brands and which ones are not dosed according to their label (he does lab testing and occasionally posts videos). People have pointed out he is biased due to being heavily sponsored by some brands, but I believe that even if he is slanted, he is not making up the lab results.

In another video, he showed Deva Coq10, not ubiquinol, had close to what the bottle says is in there.

Here is the video where he mentions healthy origins if you care to take a peak

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#38

@Bruce4654
Here is the link to the thread from the other day… there are others as well.

PS California gold is the name of the iherb house brand, i think

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#39

Yikes. That’s a lot to take in.

Do you take omerga-3 and is it a vegan version?
I do take fish oil-derived omega-3, collagen peptides and a small amount of yogurt, so I am not completely vegan.

I do have supplements from Doublewood (lithium orotate and l-ergothioneine that is derived from mushrooms). Do you take nattokinase or fucoidan derived from seaweed?

#40

Ha, well that was only a lot because my ADD dictates that I’m all over the place. Anyone else could have said all that in two sentences :slight_smile:

No reason for you to switch, but I take algae omegas
I’m currently alternating these two brands
When I want something that also contains DHA, I take
AstaMatrix that contains phospholipids. And they sell it on amazon :slight_smile:

When I’m taking EPA only, I take IWI brand Heart version
(I got this on sale at Whole Foods)

I wish I could get over myself and take collagen, strictly for vanity sake, but thus far, I’m too ick’d out by the thought (haven’t consumed meat since 1991). I’m taking Feel Vegan Collagen instead.

From anything I’ve heard, I believe algae oil is as good as fish, but I am skeptical if vegan ‘collagen’ does anything… just rolling the dice on that one.

I’m not taking nattokinase or fucoidan (hadn’t heard of fucodian). I see a lot of people do take nattokinase, but no one has told me I should, so I haven’t really looked into it.

I do have nori and I add that to my vegan caesar dressing and to spring rolls, but this is more of a 1-3x per month thing.

I’ve read that l-ergothioneine is great for us. I tired it once but didn’t rebuy it only to reduce what I’m taking. I do take tremella mushrooms from the real mushrooms brand because it’s supposed to be great for our skin… *see vanity above.

I make soy yogurt and love it (vegan or not, it’s sooo easy to make any yogurt at home with an instant pot). However, I recently discovered oat milk yogurt from Icelandic which is my new guilty pleasure (12g of protein per serve). A little too much sat fat from coconut oil for my heart disease, thus ‘guilty pleasure’

#41

You clearly have a system that works for you. I do find a number of your supplements expensive. But so long as you are comfortable with your regimen.

I have not eaten red meat in over 40 years. And no chicken for 10 years.

I never heard of oat yogurt. Maybe I should just stop yogurt and stick with Eden Kimchi Sauerkraut.
While it is probiotic, it also has a lot of sodium.

Always trade-offs.

I am 71 years old and I have an intense fear of death. And until the US allows the use of psychedelics for death-anxiety, I will do what I can to stay healthy.

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#42

I’m spending way too much on supplements and always looking for ways to find the quality/price combo… I learn a lot from the people on here!

I just saw oat yogurt for the first time last month. I only tried this one because I saw the high protein content. I don’t know what it would taste like compared to traditional yogurt, but as far as vegan yogurt goes, Icelandic vanilla flavor is soooo good. If i were consuming dairy, I’d try kefir instead of yogurt … just tossing that idea out there for you. I don’t know what it tastes like, but it supposedly has more of the good stuff in there.

To make soy yogurt, just to share because I find it shocking how easy it is. You take a carton of shelf stable soy yogurt (where the only ingredient is soy) and I toss it into a bowl inside my instant pot… i empty two probiotic capsules in there and mix (not all probiotics work)… and hit the yogurt button… let it ‘cook’ in there for 9-12 ish hours… and done… then i add vanilla … if i want labneh or more Greek style, i simply strain it… and it’s a fraction of the cost of buying anything (see, i know how to save money, SOMEtimes :slight_smile:

Good for you for eating kimchi… I can’t stand it but wish I could.

I think yogurt, as long as it’s not loaded with sugar/crap is probably very good for you, fwiw (I am personally vegan because I feel for the animals, and it’s not that I think it’s the only way to be healthy… less meat I do believe is probably healthier though… and I will cheat on special occasion when it’s really worth it… a slice of pizza in nyc a couple times a year, or for a great piece of cake).

My family has said I focus too much on my health and it gives me anxiety, but I think it’s just the opposite. I feel very empowered that I’m doing mostly everything I can for my health, so if something happens, I know I at least didn’t contribute to it.

I see you haven’t tried rapamycin yet. I have no idea what is right for you, but if you are like me, I would think going down that road will help reduce your fear of death a little bit. It’s not that rapamycin has an effect on anxiety, but it’s knowing you are doing something on the cutting edge to prolong your health on earth might help… and it’s been life changing for me and others. For many, they don’t feel anything and are just taking it for the long term benefit, but for me, the happy bonus was it turned me into a sleeper!

I also take LDN for longevity reasons… but it has been known to help people feel less anxious, too… again, I have no idea if this would be good for you. I looooove it and it makes me sleep like a baby. You can get it for aprox $30-40 a month, but if you dissolve your own high dose pills, it’s dirt dirt cheap. (Disclosure, I hated this stuff for the first couple of weeks and was going to stop, and then it flipped).

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#43

I take LDN (4 mg a night) for chronic pain. I have heard it is used for longevity. It is also supposed to increase endorphins. But after 18 months on it, I have felt no mood boost.

I have chronic pain from over-exercise and thus it now keeps me from doing any lower-body exercise. Exercise, as you know, is the real fountain of youth.

I would like to try rapamycin. I have been afraid of it given it depresses the immune system. And I don’t know how to get it prescribed. Any suggestions?

That soy yogurt may be simple for you but it’s rocket science to me. The kimchi sauerkraut is very spicy. And that is how I eat so much cruciferous veggies, a lot of spices.

I eat plain nonfat yogurt. And I add pomegranate syrup to it. Yum.

I also spend a lot on supplements. But if I were to recommend one thing, try various plant powders from Amazon or iHerb or Nuts.com. Like olive leaf.

I also love chocolate cake. I used to eat cake I got from a local diner (I live in Manhattan). But now I make my own chocolate. I put in a blender unsweetened soy milk, dates for sweetener, and a little olive oil. Emulsify. I then pour into a glass jar and add cocoa powder that I mix by hand. And I just eat it that way.

And about plastic. I am using as much glass as I can. Who knew about nano-plastics?

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#44

I love that you are on LDN. Has it had an impact on you sleep as it did mine? Sorry it has had no effect on your mood, but it is doing other good things for you, from what I’ve learned. I take 4.5. Curious, does it help your pain dramatically or just a bit? I joined the facebook group when I first started to learn more and it’s interesting to see how so many people respond differently to different doses. Lots of trial and error for some. I don’t have that kind of patience, so I’m lucky this one dose worked for me.

I also love knowing you are now my go to for recipes like blender chocolate cake. I will PM you an awesome vegan treat receipe from Yotam Ottelenghi (lots of yummy dates)… and he is where I learned about Pomegranate molasses … and yes, super yum! And this is still on topic because pomegranate contains urolitin A … full circle moment :).

If I lived in NYC, I would not eat nearly as healthy as I do… fortunately for me, there are almost no good restaurants where I live! I save a fortune by eating most of my meals at home … therefore I afford to be a sport on supplements :slight_smile:

BTW, Billy’s Bakery vegan buttercream cupcakes…get one next time you pass by… I love those things!

I also love very very spicy food, but yeah, not a fan of that pickled taste.

Ok, back to rapamycin…

First, I probably know less about any of this stuff than anyone here and I’m just parroting what I’ve learned. Others will be much better at guiding you… but …

There are multiple options for obtaining it. For me, I’m lucky that my regular doc gives it to me and I buy it in bulk with a good rx coupon from cvs… I wind up paying aprox .60 per pill. I realize most docs won’t rx it.

There are services online where you can get it from, for example, gethealthspan.com. I imagine others know of other less expensive online options. If I run across any of them, I’ll let you know.

Then there are teleheath docs, like Grant Fraser. He is very active here and he’s also an excellent doctor and a super nice guy. I also consult with him. He rx’s rapa as well. He might be licensed in nyc, or was at least working on it.

And then, there are many people here who skip the doctor route and order it directly from India. It sounds super scary and I thought that was nuts when I first arrived here, but enough very smart people do it here that I then trusted to do it, too. I now get a couple of my more expensive rx’s sent from India and it’s almost free.

We have threads containing all of this, so if you haven’t found those, say the word and I’ll find them and link them for you.

Also, on the immune system … most people here take it once a week or once every two weeks. The goal is to pulse it so it’s not making you immune compromised.

If you start to take it, eventually you can order a lab test from gethealthspan.com for $25 and then it will show your levels (you do this on a certain day after you take your dose)… we all absorb things very differently and some people find out they need to take less, and some people, like me, find out they need to take more. I’m apparently a freak, because at 104 lbs, I need 8mg per week … some men need 4mg… I started taking 1, and then 3 for a couple of weeks and then jumped to 6… I took that for almost a year before I had the labs done. Don’t be intimidated by all this… most never have their labs done, but it’s cheap and easy once the good people here tell you what to do. I’m just paying it forward!

And yes on glass!! It’s so hard!!! And thx… I’ll dip my toe in the water and order some olive leaf!

#45

Thank you for all your advice.

I see my pain doctor in September. I have been seeing him for 30 years. He may prescribe rapamycin. He already prescribed the LDN.

About LDN. I take it on faith. It may be working on the pain but I have since gotten some another problem that is the constraint so I cannot test the pain threshold. Complicated. As far as sleep, I find I need Seroquel at night for sleep. So, again, I take the Naltrexone on faith. But the longevity benefit would be a bonus.

Go to Nuts.com. They have so much that is healthy. I assume you are in the U.S. Their commercials emphasize what most people eat. But they have lots of healthy powders. Or Amazon.

As far as eating healthy. In Manhattan you can get healthy food anywhere. It may not be on the menu. But in a Chinese restaurant, I would order steamed broccoli, spinach and tofu. A little garlic source on the side. But the idea is not to eat pizza and such.

Be sure the pomegranate molasses does not have added sugar. Make sure it’s pure pomegranate concentrate.

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#46

Did you see my chocolate recipe? I don’t seem to see my reply.
It’s not a cake. It’s more like a cross between a mouse and a pudding.
I just made some more. It is chilling in the freezer.
I put 3 oz of unsweetened soy milk in a blender, add three medjool dates (no pit), and a little olive oil. I emulsify. I pour into a glass jar. Then I add and mix in cocoa powder until it is real thick. But it is trial and error.

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