#22

Thank you for bringing the good news about Urolithin A. I’m ready to start taking it, and also, would a daily dose of 1000mg offer greater benefits?

#23

I’m not sure that’s good news. Most trials are outside the inner circle so they are no significant changes.
In particular that shows again that there are mostly no significant clinical outcomes and only in-vitro ones.

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#24

However, there is no double-blind study on whether weekly administration of rapamycin, coupled with the uncertainty of weekly administration, prolongs human lifespan or improves certain inflammatory markers.

#25

Didn’t the Mannick study at least show an improvement in immune function?

#26

Yes, one phase 2 study did, for ResTORbio, but then the FDA changed the endpoints for the phase 3 trial and that trial the drug failed.

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#27

Chris Masterjohn gives a convincing reason why we shouldn’t waste our money on Urolithin A. You have to have a twitter profile to see the entire thread.

Chris Masterjohn on X: “THE CLAIM: Four months of Mitopure Urolithin A will boost your VO2max by 14.3%, your strength by 12%, and in just 8 weeks will boost your endurance by 17%, without doing any exercise! :thinking: Since four months of Mitopure costs $500, it’s worth taking a closer look at this claim. https://t.co/qX94D5emBl” / X

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The latest worm lifespan experiment：Urolithin A extended the lifespan of worms by 45%, surpassing other compounds such as rapamycin
#28

There are several brands of urolithin A in addition to Timeline. Any experience with the less expensive brands?

#29

I’m taking the capsules from get healthspan. It’s still expensive but definitely better than timeline, and I feel I can trust their quality.

Having said that, I’d love to find an even less expensive trustworthy option.

It was just last week someone here said they are sourcing it from Aeternum Urolithin A (UA) Powder – The Aeternum Company
They do 3rd party testing, so maybe this is a good source, too?
My only worry, for me, is that it’s a powder and I tend to be a baby about the taste of things.

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#30

I have seen urolithin A brands that are liposomal. What do you think about that?

#31

I am curious about liposomal supplements as well, but I don’t know enough about the topic. My number one would be if it’s a trustworthy brand and if the ingredient inside is actually UA. It’s the only reason I’m paying more at the moment, because I don’t know who to trust.

I did just buy two different supplements from Renue By Science in thinking that my gut is potentially not very good, so perhaps getting something that supposedly absorbs better was worth a shot. I hope others who are better informed chime in!

Edit: @Bruce4654 btw, I got 3 months worth at 20%, which makes them 54.66 per month. Also, I just noticed the brand that sells the powders also sells capsules with no fillers. I see each pill contains 500mg, so if this is a quality brand (I don’t know), their capsules become very affordable.

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#32

I have to admit that I take a lot of supplements and I don’t discriminate about various brands. I try to take liposomal versions for things like urolithin A and co-q 10. But I will look into Healthspan supplements. Thank you.

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#33

Addendum:
But I will say that my mainstay is a high-polyphenol, whole-plant food diet, including various mushrooms, seaweed, nuts and seeds, whole grains, beans and legumes, herbs and spices in addition to fruit and vegetables, including lots of cruciferous.

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#34

I eat similarly, but not nearly enough mushrooms and seaweed.

I’m less worried about brands for things we can measure for things like, let’s say, vitamin d… if there is no vit d in there, my labs will show it. I do follow the threads here on trustworthy brands and I try to mainly stick to those. I’ve seen the videos where they send things off for testing and there is zero active ingredients in the capsules.

After your post, I did some more searching and saw a couple of positive comments about the Aeternum brand, so I have asked my super brilliant friend if he thinks they are legit… if so, I’ll switch. I’m all about saving money when all else is equal! If you do get healthspan, definitely try to wait for one of their 20% off sales.

On liposomal…
I took a test and found out I was deficient in coq10… and because ubiquinol is supposedly more readily absorbed, I chose that. However, I did see a liposomal coq10 option and wondered if that made it equivalent to ubiquinol. Because you are taking liposomal coq10, I would love your thoughts, if you have any.

#35

I have to admit I am confused. But it’s not your fault. I just never gave much consideration to brands. I get the least expensive versions on Amazon or Vitacost brand. The co-q10 I take is Besibest brand. It’s liposomal 1000 mg of ubiquinol. I take for two days and take off one day. If I had to research every supplement brand I would go crazy. But you made me aware that I should do more research.
I do take a lot of plant powders that I mix together to make my own anti-oxidant and high-polyphenol drink. I know you said you are turned off to bad taste. But when I drink it, the bad taste lasts only a few seconds. So this homemade drink consists of spirulina, olive leaf, beets (not SuperBeets), avocado, kelp, macha green tea, black tea, Life Extension coffee, various mushroom powders, etc. Many can be purchased from Nuts.com which has more than just candy and nuts, or from Amazon.
I know I am lazy when it comes to researching the quality and reliability of supplements.

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#36

As an aside, did you know you can go to the Life Extension website and read their magazine as a pdf?

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#37

Just yesterday someone I respect here told me they take an olive leaf supplement… I had never heard of doing so… so see, you are doing much better than you give yourself credit for!

Coq10 vs ubiquinol IS confusing. I’ve gone round and round on this before!
Coq10 is called ubiquinone
Ubiquinol Is a reduced form of Coq10 and considered more bioavailable.

I definitely think you can make it easy and buy inexpensive supplements, but at the same time, the universal message that I see is be very very wary of anything sold on amazon. I will buy supplements on amazon if it’s from their ‘store’, but I no longer buy random brands from random places that I haven’t heard of.

To the best of my knowledge, vitacost is a quality company, but I have not heard about their house brand, but it might be good? iherb is also up there with vitacost and it was just within the past few days that people here were commenting that the iherb house brand is trusthworthy, so perhaps check them out.

NOW brand is universally loved and their prices are very good. That seems to be everyone’s go to. You mentioned life extension which is also seems to be a universally respected brand.

For powders people seem to like bulk supplements and pure bulk (but yeah, I have not bought the powders yet :)… on that note, and at your prompting, I might try it again. I now take a citrate powder mix, and mixing it in mango juice was recommended to me… makes it much better… so as long as I’m throwing back a quick shot while holding my nose, maybe I should consider adding some more things to it.

I checked out your ubiquinol. So, I gather you were looking for a vegan brand (I’m vegan and finding vegan ubiquinol is limiting). I’m finishing up my expensive bottle, and afterwards, I’m switching to the Healthy Origins Vegan option (they have a non vegan option, so pay attention) Ubiquinol (Vegan) 100 mg ( Active form of CoQ10) – Healthy Origins USA

I discovered them recently on a Ryker video (the anti aging YouTube channel) where he goes over the various brands and which ones are not dosed according to their label (he does lab testing and occasionally posts videos). People have pointed out he is biased due to being heavily sponsored by some brands, but I believe that even if he is slanted, he is not making up the lab results.

In another video, he showed Deva Coq10, not ubiquinol, had close to what the bottle says is in there.

Here is the video where he mentions healthy origins if you care to take a peak

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#38

@Bruce4654
Here is the link to the thread from the other day… there are others as well.

PS California gold is the name of the iherb house brand, i think

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#39

Yikes. That’s a lot to take in.

Do you take omerga-3 and is it a vegan version?
I do take fish oil-derived omega-3, collagen peptides and a small amount of yogurt, so I am not completely vegan.

I do have supplements from Doublewood (lithium orotate and l-ergothioneine that is derived from mushrooms). Do you take nattokinase or fucoidan derived from seaweed?

#40

Ha, well that was only a lot because my ADD dictates that I’m all over the place. Anyone else could have said all that in two sentences :slight_smile:

No reason for you to switch, but I take algae omegas
I’m currently alternating these two brands
When I want something that also contains DHA, I take
AstaMatrix that contains phospholipids. And they sell it on amazon :slight_smile:

When I’m taking EPA only, I take IWI brand Heart version
(I got this on sale at Whole Foods)

I wish I could get over myself and take collagen, strictly for vanity sake, but thus far, I’m too ick’d out by the thought (haven’t consumed meat since 1991). I’m taking Feel Vegan Collagen instead.

From anything I’ve heard, I believe algae oil is as good as fish, but I am skeptical if vegan ‘collagen’ does anything… just rolling the dice on that one.

I’m not taking nattokinase or fucoidan (hadn’t heard of fucodian). I see a lot of people do take nattokinase, but no one has told me I should, so I haven’t really looked into it.

I do have nori and I add that to my vegan caesar dressing and to spring rolls, but this is more of a 1-3x per month thing.

I’ve read that l-ergothioneine is great for us. I tired it once but didn’t rebuy it only to reduce what I’m taking. I do take tremella mushrooms from the real mushrooms brand because it’s supposed to be great for our skin… *see vanity above.

I make soy yogurt and love it (vegan or not, it’s sooo easy to make any yogurt at home with an instant pot). However, I recently discovered oat milk yogurt from Icelandic which is my new guilty pleasure (12g of protein per serve). A little too much sat fat from coconut oil for my heart disease, thus ‘guilty pleasure’

#41

You clearly have a system that works for you. I do find a number of your supplements expensive. But so long as you are comfortable with your regimen.

I have not eaten red meat in over 40 years. And no chicken for 10 years.

I never heard of oat yogurt. Maybe I should just stop yogurt and stick with Eden Kimchi Sauerkraut.
While it is probiotic, it also has a lot of sodium.

Always trade-offs.

I am 71 years old and I have an intense fear of death. And until the US allows the use of psychedelics for death-anxiety, I will do what I can to stay healthy.

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