#11

Thanks. It was on my face for around 2 years and I thought it was just an age spot so did nothing until my doctor saw it on an unrelated visit.

#12

Hi Alex,

I can give general information online, but not specific to anyone. I’m licensed in AU and US but not UK.

In general, I’d not see a link to a reactive node and rapamycin use. Just because 2 things occur in the same time frame, it doesn’t mean one caused the other … this is however, a pretty natural conclusion for many people.

The good news, is basal cell carcinoma is easily treated in most cases and is more of an indication of skin damage than general aging. I suspect a lot of bike riders or outside enthusiasts who spend lots of time outside have skin with lots of aging. However internally they are very healthy and I’d not think one leads to the other, as the mechanisms of the cancers that you’d be most worried about are different (with the exception of melanoma - which I think you’ll properly be surveilled for given that you’ve had a single skin cancer).

Your GP should be able to advise you on all this in detail.

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#13

Thank you for the article. I’ll read it now.

#14

Old wives tale here ( not medical advice) . Do the following: buy organic grinder, and organic garlic.
Get about 10 OZ of warm filtered water. Grind about one Oz of organic garlic and one OZ of organic ginger and add to the warm water. Take table spoon of glycine, and a spoonful of NAC, plus one spoonful of L-lysine and mix them all into the warm water. Add 1-2 OZ of alcohol into the mix and apply it often during the day. You may also want to add few drops of organic teatree oil also. Try it you’ve got nothing to lose. Let us know if it did anything and good luck. Of course seek medical help at the same time.
Btw, I’d leave this out of fridge in room temperature. A bit fermenting if it happens is probably helpful

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#15

It is quite a common cancer and I am sure the doctors will know what to do. Many people do not use sunscreen and have sun exposure (not using sun hat etc).

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#16

A quote from rivasp12:

Does rapamycin Prevent cancer in humans?

It’s already been mentioned that it may prevent the benign basal cell skin cancer, but again at transplant doses.

LaraPo would be able to say how many mg is transplant dosage.

That means high daily doses. Low dose intermittent fasting typical for longevity, hardly qualifies as cancer prevention.

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#17

Transplant doses vary much from patient to patient. All depends on how transplant works. I’m prescribed 1mg per day because all my biomarkers are very good. I take it intermittently though with many breaks.

A few years ago I developed an acne looking and not healing pimple on top of my head. My nephrologist told me that it could be cancer (because of rapamycin). However biopsy showed that it was acne, which is also typical for rapamycin. To get rid of the pimple I took a long break from rapamycin. The pimple healed very quickly after that. Since then I take rapamycin only intermittently. Never have any side effects.

I also noticed that all my biomarkers (kidney panel, lipid panel, cbc with differential, comprehensive metabolic panel) are better when measured during a break from rapamycin. Rapamycin makes all go the wrong direction :blush:

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#18

Both of my parents had basal cell skin carcinomas and both had them successfully removed using the MOHS treatment. Fortunately, this is the easiest cancer to get rid of and the least serious. I wish you well and be confident that your doctor or hospital will be able to successfully remove it. Be on the lookout for any more basal cell carcinomas, because they usually don’t appear just once.

#19

About 3.5 years ago I developed several basal cell carcinomas after two years of pretty regular rapamycin, at doses between 6-8 mgs per week. I too was concerned that rapamycin might have played a role, especially after reading a post on a (different) forum by a doctor who reported that skin cancers were common among transplant patients taking rapamycin. But who knows?
These appeared at age 61, and after a youth spent outdoors in the blazing California sun. Both of my parents also had basal cell carcinomas. But it spooked me, and I now take a lower dose and usually at intervals of 14-21 days in order to avoid too much immunosuppression.

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#20

I think the period between dosing is the key thing. If you halve the dose that sort of adds 60 hours per dose of less immune suppression. If you reduce the frequency from say weekly to 14 or 21 days you reenable the immune system to a greater extent and for longer.

I have anecdotal evidence that citrate may be of use wirh some cancer.

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#21

Taking Astaxanthin while on Rapamycin might make sense, as Astaxanthin protects the skin from UV lights etc.

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#22

Thanks, that’s useful to know.

#23

Thanks, that’s interesting. What kind of citrate?

#24

Its my citrate protocol which is a mixture of Sodium, Magnesium, Potassium and Calcium. I don’t promise anything, but it cleared a precancerous spot for someone who was taking it. (not me). It should have a positive effect on aberrant splicing. However, it has not been through any rigorous testing and I don’t promise anything (at your own risk).

Best to read the citrate protocol thread.

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#25

My nephrologist constantly reminds me not to be in the sun bc I’m on rapamycin for 14 years. I never leave home without a sun hat in summer. At almost 69 I still don’t have skin cancers. It makes sense to take astaxanthin for sure.

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#26

Are you saying that you’re advised to stay out of the sun BECAUSE you’re on rapamycin? Meaning you’re more at risk on rapamycin?

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#27

AFAIK @LaraPo is on a daily dose.

My own view is I wish to only have an effect from Rapamycin from time to time. I am currently working on a 21 day schedule, but I may make it less frequent.

#28

Exactly! I’m more at risk because of rapamycin and immune system suppression by it.

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#29

I’m not on a daily dose for several years already (even though a daily dose is prescribed). I take a total of 2 mg spread within 4 days, then I break for 7-10 days. If I take more than 2 mg, let’s say 4, then my break is 2 weeks. When I was on a daily dose I had unwanted side effects. With my current regiment I have no side effects in addition to improved biomarkers.

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#30

Whatever you do, you should follow your doctor’s advice on the dosing schedule to minimize risk of transplant rejection. That’s more important than anything else. Being influenced on people taking it for different reasons is a bit foolish in my opinion. You seem to be susceptible to listen to people too much that don’t have any expertise in the field, too.

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