It depends on the dose you are using. I have ordered some powder to enable higher dosing.
L_H
#31
The beauty of eating natto is that it alters your gut microbiome to be more mk7 productive. I’ll try to to dig out the research. So it has an enduring benefit
2 Likes
DrRoss
#32
Hi John,
The most effective method of improving mitochondrial function is NTFactor Lipids…it repairs and replaces damaged cellular and mitochondrial membranes throughout the body…which results in significant increases in ATP energy production. For more information about revolutionary life extension product email me at: rosspelton70@gmail.com
I am mildly sceptical about this. If you have good evidence for these claims please post them in the forum.
3 Likes
I’ll just leave this here
4 Likes
adssx
#36
The conclusion is that NTFactor Lipids is total bullshit, correct?
5 Likes
I haven’t seen clear evidence that it’s uniquely helpful (or helpful at all) beyond supplementation of similar lipids (soy lecithin, phosphatidylcholine, etc.). I should caveat that by saying I view case studies in tiny journals to be equivalent to forum experience posts. So, yes, this is definitely in the “probably not harmful, if you want to try it to see if it subjectively helps, go for it.” Their huge list of studies is at best clever marketing, and at worst bullshit (although arguably these are the same thing).
I’m happy to change my mind on this if @DrRoss or someone else would like to point to a specific study from their list that provides better evidence than a case study and uses NTFactor Lipids specifically (and not the multivitamin + NTFactor Lipids formulation).
3 Likes
DrRoss
#38
HI,
For those of you who want to learn more about NTFactor Lipids; it contains healthy, non-oxidized phospholipids that the body utilizes to repair cellular & mitochondrial membranes throughout the body. In scientific publications, studies with NTFactor Lipids is referred to as Membrane Lipid Replacement (MLR). Improvements in mitochondrial function with NTFactor Lipids are documented by using the Rhodamine fluorescent dye. Damaged mito membranes are not able to uptake Rhodamine dye, however healthy mito membranes take up the dye…and this can be visually observed by measuring the level of fluorescence in mito membranes. People taking NTFactor Lipids for 1 to 2 months gain significant improvement in mitochondrial membrane function. Studies in patients with fibromyalgia and chronic fatigue have documented decline in fatigue & improvements in energy.
The best study to read which reviews benefits from NTFactor Lipids is the study done with Gulf War Veterans who experienced wide-ranging health problems due to exposure to chemical, environmental and biological toxins during their tour(s) of duty. Here is the link to that study:
chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://ntfactor.com/wp-content/uploads/2022/06/59-Nicolson-et-al.-Memb.Lipid_.Replacem.Veterans.Study-Nicolson-IJTM-2022.pdf
The peer-reviewed journal Nature Cell Science recently published an extensive review article by Nicolson, et al. itled: Membrane Lipid Replacement and its Use in Restoring Mitochondrial Membrane Function and Reducing Various Symptoms in Aging and Aged-Related Clinical Conditions Here is the link to that publication:
chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://cellnatsci.com/wp-content/uploads/2025/01/10-61474-ncs-2024-00038.pdf
Feel free to contact me for more information regarding NTFactor Lipids.
Healthy regards, Ross rosspelton70@gmail.com
1 Like
DrRoss
#39
Hi Joseph,
Exercise stimulates the body to build new/more mitochondria…but it doesn’t effectively repair damaged mitochondrial membranes. Therapy with NTFactor Lipids is an autophagy-like mechanism. When autophagy is activated, damaged proteins and enzymes are broken down, and the component amino acids are used to build healthy new proteins and enzymes. However, repair of damaged cellular and mitochondrial membranes doesn’t work this way. Most people do not consume adequate amounts of healthy, non-oxidized phospholipids in their diet. Thus, the body doesn’t have the raw materials it needs to accomplish membrane lipid repair. However, NTFactor Lipids delivers therapeutic doses of healthy phospholipids, which the body then utilizes to accelerate membrane lipid repair. People feel the improvements…and it is scientifically measurable and documented. Repair and renewal of cellular and mitochondrial membranes with NTFactor Lipids is an important advancement in life extension and slowing down the process of biological aging.
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Thanks @DrRoss. This is certainly more compelling evidence than the studies I looked at as it moves up the evidence hierarchy slightly above a single case study (open label w/ 20 participants). I would still be cautious about changing my statement of “probably not helpful, not harmful”. Perhaps “If suffering from gulf war illness, possibly helpful, otherwise probably not helpful and not harmful.” I wouldn’t be opposed to extending this beyond GWI to possibly helpful for people with very very high environmental toxin load (past or present).
I’d still prefer to use soy lecithin because it has RCTs showing benefits. It’s not clear to me that NTFactor Lipids is uniquely beneficial. Perhaps in GWI the same result would have occurred with soy lecithin.
3 Likes
adssx
#41
A preliminary study on the reference intervals of vitamin K in some areas of Beijing with normal physical examination population 2025
The level of serum MK7 showed a significant upward trend with increase of age (P < 0.001).
The findings demonstrated statistically significant differences in serum VK1, MK4, and MK7 levels across the young, middle-aged, and elderly age groups. In contrast, within each age group, no significant disparities were observed between male and female subgroups. Consequently, this study utilised age-based categorization to establish reference intervals for VK1, MK4, and MK7.
The reference intervals for MK7 established in this study, both the lower and upper limits, were significantly lower than the average concentrations reported in Japanese women of different age groups (4.96, 8.42, and 4.21 ng/mL), which is closely related to the widespread consumption of vitamin K-rich natto in Japan. The lower limit of the MK7 reference interval established in this study is lower than the normal adult reference interval reported in Italy (0.33–4.48 ng/mL), with nearly 94% of the detected values below the mean of 0.85 ng/mL reported for women of reproductive age in domestic studies, yet the lower limit of our reference interval is close to the lower bound of the established reference interval of 0.12–3.54 ng/mL.
Therefore, the lower bounds of the reference intervals established in this study, except for MK4, are close to those in domestic and international related studies. The differences in the high values of the upper limits are closely related to individual differences in the study population, as well as regional and dietary nutritional status. This also suggests that different regions and individuals have a relatively consistent tolerance to vitamin K deficiency, but have a higher tolerance for different serum concentrations and high doses of VK.
Why would MK7 increase with age in healthy people?
1 Like
Potentially a variation in diet. Alternatively a change to the pathways that metabolise it. Obviously supplementation is a possiblility.
What would be useful is to know what daily consumption links to which serum concentrations.
@adssx Gut microbiome changes with age?
adssx
#45
Could be. ChatGPT suggests the potential explanations:
- Liver function declining with age (even among healthy individuals) => slower clearance or altered tissue uptake of MK7 => higher circulating levels in older age groups
- “Aging might trigger compensatory mechanisms that affect the distribution, storage, or recycling of MK7, ultimately leading to higher serum levels”
- “Even in healthy populations, the composition of the gut microbiome changes with age. These natural age-related shifts might favor the bacterial species that produce MK7, thereby increasing its endogenous levels in older individuals.”
At the end… is high MK7 good or bad? 
Association studies looked at K1 + K2 or all K2 (MKs) but not specifically MK7:
Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study
The relative risk (RR) of CHD mortality was reduced in the mid and upper tertiles of dietary menaquinone compared to the lower tertile [RR = 0.73 (95% CI: 0.45, 1.17) and 0.43 (0.24, 0.77), respectively]. Intake of menaquinone was also inversely related to all-cause mortality [RR = 0.91 (0.75, 1.09) and 0.74 (0.59, 0.92), respectively] and severe aortic calcification [odds ratio of 0.71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively].
Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis 2019
A significant association was found between dietary phylloquinone and total CHD (pooled HR 0.92; 95% CI 0.84, 0.99; I 2 = 0%; four studies), as well as menaquinone and total CHD (0.70; 95% CI 0.53, 0.93; I 2 = 32.1%; two studies). No significant association was observed between dietary vitamin K and all-cause mortality, CVD mortality, or stroke. Elevated plasma desphospho-uncarboxylated MGP (dp-ucMGP), a marker of vitamin K deficiency, was associated with an increased risk of all-cause mortality (1.84; 95% CI 1.48, 2.28; I 2 = 16.8%; five studies) and CVD mortality (1.96; 95% CI 1.47, 2.61; I 2 = 0%; two studies).
Vitamin K status and cardiovascular events or mortality: A meta-analysis 2020
Similarly, there were no significant associations of menaquinone for the risk of all-cause mortality (hazard ratio 0.96; 95% CI 0.84–1.09; I 2 = 0.0%, p = 0.707) and CVD mortality (hazard ratio 1.02; 95% CI 0.77–1.35; I 2 = 0.0%, p = 0.644) in a random effects model.
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Are we sure these cross country measurements are uniform? I’m not so sure. See:
Vitamin K plasma levels determination in human health
adssx
#48
What’s your point? (this study is briefly cited in the above article btw)
So the serum concentrations were below those you would get from supplementation
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