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Melatonin levels are both an internal clock and an internal calendar, the latter because of the changing amount of light in different seasons.
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You should take Melatonin at the same time very night.
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Avoid blue light at night, and avoid light during the night.
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Retinas have a set of photoreceptors (not cones or rods) that affect the internal clock.
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Fire light, candle light, and moon light have no blue.
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Night lights should be red, yellow, orange.
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Melatonin helps set the biological clock of a developing fetus. Nursing children for 3-4 months and maybe as long as 5-6 months do not produce melatonin – they get it from nursing. Babies who do not nurse do not receive this melatonin. Some have speculated that SIDS could have a correlation with melatonin, but this has not been studied.
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Melatonin is one of the most powerful anti-cancer hormones and it is also an antioxidant.
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Most cancers are age-related. As you age you produce less melatonin. Melatonin suppresses tumor growth and cancer growth.
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Melatonin is part of your body’s repair and regeneration process.
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Melatonin should be more widely used because of the misuse of light.
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We could reduce some negative age-related effects on health through the use of melatonin.
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Animal studies show that cancer, neuro-degenerative diseases are inhibited by melatonin.
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People fighting cancer may want to take melatonin during the day as well as night, because it leaves the body quickly.
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Melatonin can also help sepsis.
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Does taking Melatonin reduce your body’s ability to produce Melatonin? Melatonin in the body is produced in the pineal glad. This Melatonin is controlled by the nervous system and not by endocrine feedback. Therefore, there is no evidence of this.
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Blind people have lower rates of certain cancers. This could have to do with their high levels of melatonin.
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Melatonin levels drop as we age. If you take 75 year olds and separate them by health level, those who are more healthy have more melatonin. Could be one way or the other, but there is the correlation.
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How much do you take at night? Started with 3-5 mg as a young person. To defer aging, a 45 year old person might take 10mg. But others more. He is reluctant to say how much he takes because he doesn’t want to make a recommendation. But he does take 100mg nightly “for a very specific reason.” It is also very anti-viral. He wants to impede the likelihood that he’ll get COVID. If not for COVID he would be taking less. Probably 30-50mg/night as an 85 year old.
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Six clinical trials on Melatonin and COVID were currently being conducted when the video was made. They have all shown it helps: reduce either the severity of the infection, duration of hospitalization, necessity for tracheal intubation, decreased mortality.
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Melatonin is cheaper than aspirin.
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Older people have lower melatonin. They also tend to take more prescription medications. Some of these reduce melatonin levels.
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Does alcohol affect melatonin? Yes, particular if late in the day or evening. Also coffee.
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Women are delaying child-bearing. This leads to some negative effects in the children. Melatonin seems to help protect against this. Women in late reproductive periods should take melatonin, also helps preserve the reproductive system.
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There is very little evidence that it ever has negative effects.
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Melatonin is an anti-viral generally, even against the common cold. Zika, Ebola. Up-regulates the immune system.
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Ebola: WHO says any reasonable treatment should be used to help if it helps. Melatonin can help.
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Blue-blocker glasses: are these helpful? One or two studies say maybe. Often they’re not wrap-around. If you’re going to wear them they should be like goggles. Avoid blue light in the the evening by any means. But they are so-so as a help.
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Astronauts change the wavelengths of the light on the space stations. Light is a drug that impacts our physiology.
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Oxidative stress is a great pressure on the body.
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Infrared light from the sun has an effect on melatonin in the body. This has high permeability. It impacts cells directly.
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Melatonin is produced in the pineal gland. It is also produced in the body, in cells, but it is never released into the blood.
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Infrared light has impacts on melatonin synthesis in the cells.
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Sunlight changes during the day: In the early morning hours we’re getting mostly infrared. Later UV. In late afternoon back to infra-red. The infrared actually helps repair skin damage, so morning and evening sun help the skin to repair what is caused by the midday UV.
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So melatonin is also produced during the day – not in the blood but in the cell.
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Cancer cells produce less melatonin than normal cells. Warberger Effect. They are deficient in the way of protecting themselves with melatonin.
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Melatonin reduces the effect of metastasis. It has actions that suggest it would be anti-metastatic.
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Melatonin is absorbed from the blood by the cell and by the mitochondria. Supplemental melatonin encourages in-cell production of melatonin.
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Can infrared light from devices also encourage the body to produce melatonin? Probably, it is the light that does it.
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The evidence regrind stroke and heart attack – those cells don’t regenerate or don’t do it very well. Aspirin is often chewed to get it in the blood quickly. This doctor would immediately load up on melatonin if he had a heart attack. What dose? 100mg perhaps several times over that next 24 hours. Not a recommendation.
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Melatonin is not magical. It is just a good wholesome molecule that evolved to help cells operate at a maximum level. Benefits greatly outweigh the risks.
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Some say 120-150mg a day. Is that too much? Different cancers, comorbidities may suggest different amounts. But…
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You can’t overdose on melatonin.
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The optimal dose is hard to decide upon. The double-blind studies have not been done. But don’t be afraid of taking too much.
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Are there any side effects that might suggest an overdose? Sleepy? Dizzy? This is hard to quantify. There could be some unique metabolic issues for some people in some times where Melatonin might not be recommended.
