Update: I’m off LDN now. The move up to 4.5mg was a mistake. I lost the sleep benefit I had gotten at the lower dose. And now I am working on using zero chemicals to support sleep so I can learn how to sleep naturally. LDN does have amazing benefits for eliminating cravings. I don’t need that effect but I could still feel it.
Onward and upward.
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jnorm
#129
I’ve been wanting to try LDN, mostly to see if it would help with chronic gastritis symptoms I’ve dealt with for the past four years. They’re probably 95% better than they were a year ago, and I mostly attribute this to quitting coffee, removing dietary triggers, and supplementation (I believe butyrate has been instrumental in the healing process).
It would be nice if I had zero symptoms though, which is why I would consider something like LDN. Naloxone (similar pharmacology to naltrexone) is OTC where I live as an opioid overdose antidote, but I refuse to pay $45 for 9mg (you’d think they’d be a little less greedy with lifesaving measures, but it generally seems to go the opposite direction).
My guess is that poor response to naltrexone is from inhibition of endogenous opioid signaling with higher doses. Stereoselective naltrexone would be a much better option, as (+)-naltrexone lacks activity at opioid receptors, but retains antagonist activity at TLR4.
TLR4 activation by morphine was shown to produce inflammation of the periaqueductal grey/PAG and this led to morphine tolerance. This suggests that PAG inflammation weakens its gating of ascending pain signals, which suggests that LDN might be primarily targeting (neuro)inflammatory pain.
Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling
If you are comfortable getting it from India, that’s where I get mine, the prices from
Jagdish Nikose at RL Pharma. rlhealthcare1928@gmail.com
Naltrexone LDN 1.5 Capsule = 2 USD For 10 Capsule.
Naltrexone LDN 3.0 Capsule = 2.2 USD For 10 Capsule.
This is what I received. They are capsules so it’s not convenient to adjust the dose downwards.
I experimented and found that the 3mg dose was right for me.
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I’ve seen a lot of that and have heard good things about it from a Facebook group, but does it say who manufactures it?
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I really don’t know. Only that Jagdish Nikose is a pharmacist according to Linkedin and he has been a trusted supplier for over 2 years. I have never had any reason to doubt the legitimacy of the products he supplies.
You could ask him for a quote and who makes it.
Jagdish Nikose at RL Pharma. rlhealthcare1928@gmail.com
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That is rather bizarre that the manufacturer of the product is not identified on the product box… definitely not a good sign, from a quality/reputation perspective.
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Excellent, I use an Indian supplier. Would you please share the generic name and dosage so that I could request it from them? Many thanks!
Apologies, you answered my question 
I’ve been curious about that since I first saw it on Facebook. I’m going to reach out to a Jagdish and another vendor to see where they get it. I suspect it is a compounded product, but by whom?
Edit: Jagdish is quick on WhatsApp. He says the product was discontinued and is no longer available. He didn’t answer who made it, but it seems a moot point aside from those who are selling remaining stock. I’ll probably do agelessrx or dissolve the 50mg tablets in water as is commonly suggested elsewhere.
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I don’t think it’s from a compounding pharmacy. If Jagdish doesn’t have it, it still is widely available.
This is just a sample. It is probably available from at least a hundred Indian suppliers. This is a sample of today’s offers and they look exactly like the ones I received.
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I noticed the availability from other vendors also, so I took Jagdish to mean that he can’t acquire new stock. I didn’t want to press him on it. He just said twice that it is no longer manufactured. Maybe he is misinformed or maybe it’s just a communication problem. Either way, he couldn’t or wouldn’t tell me who made it. I may ask other vendors because I would like to know if only to satisfy my curiosity.
Edit: Sachin of SS Medex confirms it was discontinued. He also did not answer the part about the manufacturer.
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I had high hopes for GABA, but at times it screwed up my breathing as well. Weird? Yes! During these episodes (usually in the middle of the night) I’d consciously feel the need to breathe very deep, repeatedly. Almost like I thought I was in danger of suffocating. I was afraid I’d hyperventilate, but that never happened.
With respect to LDN, I’m very close to giving it a try, and this thread has been very helpful.
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Good luck with LDN. I think it is has magical effects on people who need it. Plus it totally kills cravings. Use the lowest dose that provides the effect you seek. In my experience with LDN, a little too much wrecks it.
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Desertshores, are you still taking the LDN? Where did you order it from? I am desperately trying to find something to help me sleep; did it continue to help you sleep better? “It also significantly reduces sleep onset latency.” That is the issue I have with some of the sleep inducing meds.
I am not currently taking LDN. It did nothing for me that I could detect except that it made some foods taste odd. If I were using it for sleep I would start with a dose of 2.25mg.
Just buy the 4.5mg and cut the tablets in half. Some people have had a good result from taking it.
Email Jagdish Nikose and ask for a quote for the amount you want to buy.
rlhealthcare1928@gmail.com
I use Wise to pay him: Wise, Formerly TransferWise: Online Money Transfers | International Banking Features
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Low-dose Naltrexone (LDN) extends healthspan and lifespan in C. elegans via SKN-1 activation
As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltrexone from the Library of Integrated Network-based Cellular Signatures (LINCS) based on several selection criteria. Low-dose naltrexone (LDN) has gained attention for treating various diseases, yet its impact on longevity remains underexplored. Our study on C. elegans demonstrated that a low dose, but not high-dose, of naltrexone extended healthspan and lifespan. This effect was mediated through SKN-1 (NRF2 in mammals) signaling, influencing innate immune gene expression and upregulating oxidative stress responses. With LDN’s low side effects profile, our findings underscore its potential as a geroprotector, suggesting further exploration for promoting healthy aging in humans is warranted.
https://www.cell.com/iscience/fulltext/S2589-0042(24)01171-4
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Ludovic
#145
I have a question about LDN. It noticed on by recent blood test I have an elevated neutrophil-to-lymphocyte ratio (NLR). Here is a good paper about this “marker”:
LDN is supposed to “modulates the immune system by increasing regulatory T-cells and reducing pro-inflammatory activity, which may lead to a higher lymphocyte-to-neutrophil ratio”.
Has anyone on LDN seen this effect on blood tests?
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Beth
#146
Just hearing about LDN for the first time. I see it can be used with autoimmune conditions, such as Hashimoto’s.
Does anyone know much about using it for hashimoto’s? An initial google search mentions inflammation… I’m already on colchicine, so perhaps no additional benefit. I’m on too many things now and wouldn’t be adding this, but curious.
I’ve been taking LDN for about six months, currently 3mg around bedtime. The biggest potential benefit I’ve experienced is its seeming effectiveness in suppressing Restless Legs Syndrome. I need to experiment more with this, but for me, if I can prove to myself that taking LDN is the reason my RLS is 98% reduced, I’ll be taking this for a long time.
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