KarlT
#92
A potentially dangerous attitude to take. And the expert you choose to follow has cancer?
2 Likes
Mikhail Blagosklonny does have cancer because he was an avid smoker. The fact is that the experts are guessing just as we are. They read the same material that we do. Some are more cautious than others. I like Dr. B and Dr. Kaberlein, although I prefer Dr. Kaberlein more. However, even he goes back and forth between high and low doses. I’ve noticed that he tends to be more cautious (low doses) when speaking to individuals and more aggressive (high doses) when speaking theoretically with researchers. I can see both points as being valid.
However, I do believe that the animal data is telling us that high doses are very effective. Unfortunately, we don’t have animal data telling us the effectiveness of low doses. What we need is a study that fills that gap. Until we do, I think I need to do a period of high dose and mitigate the side effects with Metformin, Bempedoic Acid, Empagliflozin, Acarbose, etc…
6 Likes
LaraPo
#94
We don’t know if it was a cause or the only cause of his cancer. Would be nice to know. What if overdosing on Rapa for years created favorable conditions for cancer development?
2 Likes
Rapamycin is a chemotherapy agent that slows tumor growth. It’s used in conjunction with many other chemotherapies to enhance their cancer-killing effects. Somehow, I really doubt it would cause cancer. It’s FDA approved to treat some forms of cancer.
I’ll put my money on the daily smokes.
6 Likes
Thor1
#96
Thank goodness someone close to my dosing. Everyone here seems to take so much. I started about 4 months ago w 2mg every week (recommended dosage Dr. Green). I am used to it now and its ok. I squeezed some grapefruits and drank juice about an hour before dosing. It was Ok day one, tired day 2. I haven’t heard about combining with fasting. Could you explain more about that approach?
1 Like
@Thor1 Others have looked harder into the science of rapa and of fasting, and how to combine them for benefit. Do a search on this forum for a ton of discussion. Here is a link to a useful post
For me it comes down to convenience. I want to do one 24 hour fast (including all drugs and supplements) every week. I also want to take rapamycin. Both interfere with my physical activity so doing them together lowers the lost time. I hate doing both so together lowers the time in misery. Also, I want the rapa to clear quickly so I want an empty stomach, so that fits. I eat grapefruit before I take Rapa, so that’s not exactly fasting but im not fanatical about it. Maybe there is a combination benefit, but some people here don’t think so.
I try not to be a slave to my longevity efforts. I try to emphasize things that I enjoy (or can learn to enjoy) that also make me healthy. Repetition and reward make a habit.
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Thor1
#98
This very close to my sentiments and how I approach overall health. Thank you!
2 Likes
Bicep
#99
If you chew a couple acarbose before the grapefruit your gut buddies will get the sugar from the grapefruit, and acarbose is supposed to increase MTor2. Just an idea.
5 Likes
LaraPo
#100
A few years ago I overdosed on Rapa which resulted in temporary lung scarring. It was resolved though after I stopped Rapa for 4 months and then restarted on a much smaller dose. Dose is everything. Rapa is known to detrimentally affect healthy lungs. My point is that lungs of a smoker could be affected even more.
Rapamycin is used to treat certain lung conditions like lymphangioleiomyomatosis (LAM), where it helps reduce the loss of lung function¹. However, it can also cause some serious side effects, including:
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Pulmonary fibrosis (lung scarring and stiffening)
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Pneumonitis (lung inflammation)
Source: Conversation with Copilot, 6/26/2024
(1) Lung function response and side effects to rapamycin for … - Thorax. Lung function response and side effects to rapamycin for lymphangioleiomyomatosis: a prospective national cohort study | Thorax.
(2) Rapamune Side Effects: Common, Severe, Long Term - Drugs.com. Rapamune Side Effects: Common, Severe, Long Term.
8 Likes
Of course, you, as usual, as seems to be your nature, reply by redirecting a conversation away from its original topic. When was the last time you even tried to contribute something meaningful and not snarky?
Having said that, would you care to match your credentials with Dr. Blagosklonny’s?
He is a cancer expert, you are not. He is a rapamycin expert, you are not.
3 Likes
Hey you kids… get off my lawn. 
I can’t help it sometmes. Hahaha.
5 Likes
dlkmd
#103
That sounds like a good plan BUT what is the “therapeutic range” for longevity vs transplant immune suppression.
dlkmd
#104
Hi Candleflower,
I am a PI on a rapamycin trial with ME/CFS patients. We monitor cbc/cmp/lipid panel or apoB, A1C and hs CRP. An LDL of 150 is already quite high so rapa may certainly make that worse.
1 Like
I posted about your trial on Twitter / X a few months ago. How is recruitment going? Perhaps we should cover it more here if you need more volunteers - let us know.
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Do you know of an updated summary of Blagosklonny’s stack. Here is an old tweet of his
He is an interesting counterweight to the conservative longevity scientists I usually listen to. I also think Blagosklonny is very smart and knowledgeable about Rapamycin and more.
4 Likes
@约瑟夫_拉维尔 I admire how you want to do things the natural way without many medicines and supplements. However, people have been trying that method since the dawn of mankind. You just can’t break 122 au naturel.
Rapamycin is the key to unlocking the door to longevity. However, there are medicines and supplements that complement Rapa. I’d argue for the classic deficiency treating supplements plus amino acids. After that, I’d argue for the medicines that increase lifespan and healthspan and minimize Rapa’s side effects such as an SGLT2I, Metformin, Bempedoic Acid, Ezetemibe, Telmisartan, and Acarbose.
I think those are the bare minimum although I am sure that there are others that will extend lifespan out there as well.
But of course you also need the basics of diet, exercise, sleep, etc…
Here’s hoping we all can break that 122 barrier!
10 Likes
@DeStrider I think the main idea is to survive until better treatments are available, and in the meantime don’t damage yourself. Since no one knows how to implement this strategy, there is no right way to do it. We could agree and argue about many wrong ways to do it.
I don’t try to convince anyone of anything. I am here to learn from people who have an education or experience I don’t have, or just a good mind against which to sharpen my own mind.
So far so good. Thanks.
7 Likes
SNK
#109
that’s a very high dose especially doing it weekly, but glad you have no sides. I’m a male 240lbs and do 5mg without anything, no side effect. When i was 5mg with GFJ I was prone to infections(mainly skin)…so I stopped GFJ.
3 Likes
@约瑟夫_拉维尔 Good point about waiting for something better. There probably will be. I hope it gets here soon.
That’s a big advantage we have over previous generations. Something better is always coming.
It’s times like these that I wish I was from a younger generation. I hope I don’t miss immortality. 
2 Likes
AnUser
#111
What do you think the immune system does?
