#28

John,
Yes, stopping seed and vegetable oils - alone - may not reverse PD.
It might or might not slow it.
That is just one of the things that could be done (and it is something that everyone should do, whether they have PD or AD or chronic fatigue).
For reversing PD, take a look at these:
https://lowtoxinforum.com/threads/thiamine-b1-reverses-parkinson-disease-in-humans.8305/
https://lowtoxinforum.com/threads/niacinamide-may-be-a-viable-treatment-for-parkinson-disease-pd.24281/
https://lowtoxinforum.com/threads/taurine-like-compounds-may-treat-parkinson-disease.7482/

#29

My loved one is going thru LBD now. We are starting our sixth year. The progression has been relentless. One of the earliest problems was navigating down steps. She fell several times carrying a laundry basket => fractured wrist. It progressed to overt lower visual field neglect (that means, while not blind in the lower visual fields, she could not process what she was in fact seeing, hence the falls). This lower visual field neglect was missed by the neurologist but became evident in watching my wife eat-- eventually she would feel for food on her plate and now I must feed her all but “finger food”. So this visual-spatial disconnect led to more disability. For example, on the last day that she drove yrs ago, she pulled into the oncoming lane of traffic on a turn when I was testing her driving. (Glad I did.) Over the last 5 yrs, she has also developed significant bradykinesia (all movements are extremely slow along with another Parkinsonian feature, almost complete loss of balance (but absent the tremor of Parkinson’s). Also increasingly evident over the last 5 yrs is REM sleep behavior disorder (RBD for short) where she has terrible screaming nightmares, everyday including naps. While her memory is failing, it was a relative late-comer compared to these other signs. Though, early on she had terrible impulsive buying behavior. I had to cut off her credit cards early. Another sign she developed is echolalia- she will repeat whatever I say (“Honey, hold this grab bar here”…she repeats). Obviously, more has developed but we won’t go there and she now requires my help for all aspects of her life. In the end, we can debate whether this represents LBD, Parkinson’s with dementia, Alzheimer’s, frontotemporal dementia, vascular dementia, posterior cortical atrophy with AD, etc, but her doc and I agree, there is no magic bullet. Good luck to you and your loved one. If you ever need tips on navigating the difficulties ahead, I’m happy to tell you how I resolved many of these.

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#30

There seems to be so many inconsistencies and qualifications in studies, at least for one not knowledgeable in reading them. I do have an issue when the Nurses health Study and others like that report correlations as I’m familiar with it and it relies too much on subjective memory imo. Re drinking, my brother would agree he was a functioning alcoholic, the amount he’s consumed over his life could not be good for his brain. He still drinks a little but not much. Guess no way to know if it was a contributing factor, but that’s water under the bridge…

Some influencers like Andrew Huberman and Peter Attia are now saying zero alcohol is the best. Who knows….

#31

Oh what you and your wife are going through. It’s heartbreaking. Thank you so much for your offer to share your experience/tips as we go along. It’s 3 years since his diagnosis, he was having hand tremors and his leg would jerk at times, that’s what prompted the doctor visit. Since then his balance has worsened and he gets dizzy occasionally. I remember before any of this I noticed he shuffled and I would say Billy pick up your feet, but didn’t think too much of it. (We live in different states this was via FaceTime.) I have to be careful how much I share with his wife because it just upsets her. I can understand her reluctance but…….he will need to be further along before she takes the really hard look at it. Honestly I’m still in a bit of denial too. The nightmares your wife has must be so difficult, it seems medicine could at least do something for the sleep issues. Thanks so much for sharing some of your experience Dr. Chase, I’m just so sorry you have it to share.

#32

Thank you for sharing your story. I’m sorry for what you are both going through. Sending hugs.

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#33

Sorry to hear what you’re going through.

For RBD, I would look at the following:

  • Tanganil (N-acetyl-DL-leucine): A bit of ADLL for RBD – The Science of Parkinson's . In the German paper, benefits appear after just a few weeks. On Health Unlocked, several people with RBD reported similar quick benefits: https://healthunlocked.com/cure-parkinsons Tanganil is only available in France (I’m happy to send you boxes for free). N-acetyl-L-leucine is available in the US (just approved a few months ago) but it very expensive.
  • High-dose melatonin: melatonin is the default treatment for RBD, but it might not be given at a high enough dose.
  • Prazosin or terazosin:
    • Prazosin is used to treat PTSD nightmares. It might work as well for RBD: Parkinson's disease - #645 by adssx
    • Terazosin (of the same family) is explored in RBD, DLB, and PD with ongoing trials (and others about to start), see this thread: Terazosin / doxazosin / alfuzosin may protect against dementia with Lewy bodies
    • The issue with both is orthostatic hypotension, but you can start with a very low dose (taken at bedtime). I see benefits in my energy levels from just 0.5 mg terazosin. Terazosin might help with urinary symptoms as well (it’s normally approved for prostate enlargement).

We have a dedicated thread for PD that you might be interested in: Parkinson's disease

In particular, here are interventions that I think might be effective (my two cents and I’m obviously not a doctor): Parkinson's disease - #429 by adssx

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#34

Thank you all for your thoughts. I have some homework now! An interesting aspect to this disease process is the relative lack of information on how to cope with the inevitable changes. For example, just last evening I showed a practicing physical therapist with experience in this area my discovery of a “chair lift” (chair lift on Amazon. She had never heard of this type of device but has aided us many times.

1 Like
#35

I have homework too - TY again Antoine. I hope you can find something that helps, my brother was given 10mg of melatonin. Antoine you said one drug helped with energy, so assume you’ve noticed at least some change in that?

#36

Oh my I just checked out those links and it makes ones head spin. I admire you for going down every avenue. One thing that caught my eye is folks do better at high altitude. I live at 6800 in Colorado and my brother in Austin. They visit 2 weeks a year so I’m going to have him pay attention this summer if he notices any difference. And the hypoxia in a pill is interesting. I just started breathing exercises for sleep apnea where one needs to have air hunger it’s thought we breathe more than we should. I’ve heard (you tube MD out of Charlotte NC) NAD does nothing orally it must be IV for greatest effect sub Q will have some. Sounds like you were waiting on it at that time anyway. Are you taking the OTC cough medicine someone mentioned?

#37

Hi Candleflower

It is very touching that you care so much about your loved ones.

Now to your question: Alzheimer’s and Parkinson’s diseases are associated, according to some studies, with gut health. The gut-brain axis. The development of inflammation in the gut, irritable bowel syndrome, bacterial overgrowth syndrome, and “leaky gut” lead to the development of many neurodegenerative and autoimmune diseases.

I have thought about these issues for a long time and have come to the conclusion that these processes can not only be stopped, but also reversed

What I would do if I were you:

  1. Carefully read the book: Dr. Steven R Gundry The Plant Paradox: The Hidden Dangers in “Healthy” Foods That Cause Disease and Weight Gain and use the nutritional advice.

  2. Take the hydrogen breath test and Fecal calprotectin (FCAL) to confirm inflammation in the gut

  3. Would watch videos that explain how to deal with such gut problems

  1. Would take 6-8 grams of creatine daily

  2. Would take 1 mg of lithium in the morning

Whatever would not do categorically:

  1. Avoid taking non-steroidal anti-inflammatory drugs, such as ibuprofen, as these have a very negative effect on the small intestine

  2. If possible not to take antibiotics or at least categorically avoid taking fluoroquinolone antibiotics like Ciprofloxacin. If there is an indication to prescribe antibiotics, any other antibiotics, but not fluoroquinalones.

Everything written above is absolutely safe. Maybe it will help you with your problems

I apologize for my English, maybe something will not be clear. It’s not my first language.

1 Like
#38

Creatine showed no long-term benefits in PD.

And yet ibuprofen is protective against PD.

Similarly, antibiotics use is associated with less (not more) PD. But it’s true that not all antibiotics are good.

So it’s way more complex. And basically most of what you said is incorrect.

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#39

I don’t want to open a discussion, but you are wrong. Non-steroidal anti-inflammatory drugs do not actually help, but worsen the condition. It is like in rheumotoid arthritis, ibuprofen reduces pain, but increases inflammation of the small intestine and, consequently, the course of the disease and requires ibuprofen to reduce pain and again worsen the overall condition. You are falling into a logical trap.

It’s really quite complicated, but I’m right globally.
The main thing is to remove inflammation in the small intestine, i.e. the root cause of the disease.

#40

Different people have different views as to what the mechanism of parkinsons is. I think it relates to accelerated damage to brain cells as a consequence of a shortage of melatonin. You think it is something to do with inflammation in the small instestine.

I can explain every step in the process from my mechanism. How do you link inflammation in the small intestine to damage in the brain?

#41

Not all NSAIDs are the same: Use of ibuprofen and risk of Parkinson disease 2011

We identified 291 incident PD cases during 6 years of follow-up. Users of ibuprofen had a significantly lower PD risk than nonusers (relative risk [RR], adjusted for age, smoking, caffeine, and other covariates = 0.62; 95% confidence interval [CI] 0.42–0.93; p = 0.02). There was a dose–response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0.01). In contrast, PD risk was not significantly related to use of aspirin (RR = 0.99; 95% CI 0.78–1.26), other NSAIDs (RR = 1.26; 95% CI 0.86–1.84), or acetaminophen (RR = 0.86; 95% CI 0.62–1.18). Similar results were obtained in the meta-analyses: the pooled RR was 0.73 (95% CI 0.63–0.85; p < 0.0001) for ibuprofen use, whereas use of other types of analgesics was not associated with lower PD risk.

NSAID Use and the Risk of Parkinson’s Disease: Systematic Review and Meta-Analysis of Observational Studies 2012

The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15).

You’ll have to explain why many papers found that ibuprofen users had a lower risk of developing Parkinson’s disease.

The relation between Parkinson’s disease and non-steroidal anti-inflammatories; a systematic review and meta-analysis 2024

The ORs of PD occurrence in patients who took NSAIDs, Ibuprofen, and non-aspirin NSAIDs were 0.88 [95% CI (0.8–0.97), p = 0.01], 0.73 [95% CI (0.53–1), p = 0.05] and 0.85 [95% CI (0.75–0.97), p = 0.01]. Meanwhile, the risk of PD in patients who took aspirin was not statistically significant.

Other papers found no difference, but none found an increased risk:

NSAID use is not associated with Parkinson’s disease incidence: A Norwegian Prescription Database study 2021

Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis 2025

A total of 18 studies were included in the analysis to assess the overall effect of NSAIDs on the risk of PD (Figure 2). The RR with a 95 % CI was 0.96 (0.83–1.11), with a p-value of 0.57. This suggests that there is no statistically significant association between the use of NSAIDs and the risk of PD.

If your theory was correct, we would expect that NSAID users would have an increased prevalence of PD. That’s not the case. It might even be the opposite.

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#42

The situation with antibiotics is complex. Like NSAIDs, it’s not a homogenous class: some antibiotics might be detrimental while others might be beneficial:

So saying “If possible not to take antibiotics” is not helpful.

If inflammation is causal, then why is C-reactive protein (CRP) protective? See: Early detection of Parkinson’s disease through multiplex blood and urine biomarkers prior to clinical diagnosis 2025

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#43

Thank you, Antoine, you are doing the Lord’s work here. I saw Viktor’s post and was going to respond, but didn’t have the energy, there are so many of such, and responding to each is like fighting weeds, soon there’s a new one. Life is too short to have to repeat the same things over and over again. I posted a study in another thread showing that NSAIDs were helpful in dementia, so whatever impact on leaky gut, it’s net positive - and this is a brand new one from this month:

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk

https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.19411

And Viktor recommended a book by S. Gundry. That’s a red flag. Gundry is a notorious money spinner peddling discredited conspiracy theories to generate cash. He’s all over yt and in ads all over the net, the guy is a misinformation industry. Anyone who thinks that guy has any credibility really has done no research. The moment I saw that name, I could’ve stopped reading. It’s like you want to discuss astronomy and somebody starts the discussion by recommending a flat earth book - this is not going to go anywhere.

I was wondering if perhaps we could have a pinned post or FAQ where the most common talking points surrounding useless recommendations for conditions like PD and cholesterol denialism are dealt with citing studies, and whenever a poster comes along repeating one of those, one could send them to the FAQ/pin, instead of trying to deal with the same points over and over again. If we could do some kind of wiki here we could cut down on noise quite a bit?

4 Likes
#44

It’s not my theory, but I fully support it. Since I don’t see a clear explanation for many diseases.
The gist of it: damage to the intestine (leaky gut) and subsequent inflammation, with increased levels of calprotectin in the feces and this is a marker of inflammation.
There is a lot of work supporting this theory:
https://www.nature.com/articles/s41598-023-45929-z

Exploratory analyses indicated that calprotectin levels were also associated with cerebrospinal fluid markers of AD, and with lower verbal memory function even among cognitively unimpaired participants. Taken together, these findings suggest that intestinal inflammation is linked with brain pathology even in the earliest disease stages. Moreover, intestinal inflammation may exacerbate the progression toward AD.

https://www.sciencedirect.com/science/article/abs/pii/S1568163723003021?via%3Dihub

Benefit of this review was to elucidate that high fecal calprotectin level in PD patients indicated gut dysbiosis and intestinal inflammation. Early increment of fecal calprotectin indicates the development of gut dysbiosis and/or gut-barrier injury which may precede motor symptoms by decades. Thus, fecal calprotectin could be a diagnostic and prognostic biomarker in PD. preclinical and clinical studies are warranted in this regard to emphasize the potential role of fecal calprotectin in PD neuropathology.

I can’t agree, but here’s another book that completely confirms the information in the first one:
David Perlmutter BRAIN MAKER
Or is Perlmutter also a red flag?

#45

Correlation is not causation.

1 Like
#46

Good to admit that you neither know nor understand anything. Ciao goodbye.

#47

I agree, there’s no clear solution.
There are hypotheses, and this hypothesis seems to me the most plausible.
Here are a couple more videos on the subject:

I’d love to say goodbye to you, too
Your level of narcissism is off the charts.