#81

Thank you for your well-reasoned and detailed response. You are clearly more skilled at interpreting this article than I am. I share your concern that we could not find a published version of this 2019 preprint. Was it ever submitted for publication? Was it rejected? I don’t know.

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#82

I wasn’t able to find out if it was ever published beyond the pre-print status. I found a bunch of references but all to the same paper you and i saw.

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#83

The question is what is “elderly”? Are you sure you are “elderly”, you definitely don’t look like one.

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#84

I wondered this as well @LaraPo. When you dig into the claim it seems a possibility that the researchers have conflated age, say 70 or older, with physical condition, such as frailty, sarcopenia, etc. I would like to see a study stratified not by age but some of the standard fitness metrics.

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#85

Metformin protects against vascular calcification. The metformin dosage used in the current study (1 mM) and inadditional in vitro experiments (0.5 mM) (Cao et al.,2013;Qiuet al.,2021) can be correlated to the high dosage of metformin(>1700 mg/day) used in human clinical trials. Interestingly, only this highdosage was able to reduce triglyceride levels and high‐densitylipoprotein function, which may contribute to the anti‐atheroscleroticeffect (Luo et al.,2019). F

https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcp.30887

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#86

The picture is flattering and was just a lucky shot selected from several that weren’t as flattering. But I do believe based on what I see at my doctor’s office and what I am told, I do look younger than most 83-year-olds. When I look in the mirror I see an old man even though I don’t feel that way inside.

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#87

Stop looking in the mirror @desertshores and just feel good about yourself.

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#88

Dr. Mercola had a article on the fatality of Rapamycin in diabetics. It has to do with the ATP Cycle.

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