#158

There’s no reason not to. It’s dirt cheap, at least from India.
It’s the one the study used.
There is no reason to think tadalafil is superior. At least there is no proof that it is.
Due to its long half-life, dosing is more problematic.
Maybe the shorter half-life of sildenafil will cause you less problems.

4 Likes
#159

Indeed. Good that you wrote this - a reminder for me to get on board for sildenafil. Muscle cramps are less reported on sildenafil (quite uncommon) than with tadalafil and if they do show up I will know now to quit at once.

#161

How concerned should we be with the risk of viagra causing eye problems? I’m not talking about going blind, although going blind is no fun, but may there also be more subtle damage to the eye? The danger of damage being irreversible is giving me pause.

#162

Here is a fair summary on this topic:
Visual changes associated with Viagra (sildenafil) and Cialis (tadalafil) are generally reversible and temporary. These medications, which are phosphodiesterase type 5 (PDE5) inhibitors, can cause mild and transient visual symptoms due to their effect on phosphodiesterase type 6 (PDE6) in the retina. Common visual side effects include changes in color vision, light perception disturbances, blurred vision, and photophobia. These symptoms occur in approximately 3-11% of users and are usually non-permanent, resolving after discontinuation of the drug 12.

For sildenafil, visual effects typically last 3-5 hours, aligning with the drug’s half-life. In the case of tadalafil, effects may last longer due to its extended half-life of 17.5 hours. However, these effects are generally reversible once the drug is metabolized and eliminated from the body 23.

While serious vision-threatening complications such as nonarteritic anterior ischemic optic neuropathy (NAION) are rarely reported, there is a lack of conclusive evidence linking PDE5 inhibitors directly to these severe ocular events. The incidence of such complications in users does not appear to exceed that in the general population 36.

In summary, while sildenafil and tadalafil can cause visual changes, these effects are typically reversible. Patients experiencing visual disturbances should consult their healthcare provider for appropriate evaluation and management, which may include discontinuation of the drug if necessary.

5 Likes
#163

Isn’t there also a type of retinal detachment linked to the PDE5 inhibitors? I believe it was serous retinal detachment. Still very rare, though.

#164

Thanks. 11% of users doesn’t strike me as rare. And to get rid of the effect you have to stop the medication altogether, there’s no “eventual adjustment”. I might be excessively risk averse, but I’ll pass on these meds.