I found this from the Wizard Sciences, I thought this was good information to share.
I do wonder how Methylene Blue and Rapamycin work together? Thoughts?
Methylene Blue
Methylene Blue can be found in our:
Methylene blue is a blue dye developed back in the 1860’s by scientists who were working for the textile industry. They were dying cotton and wool blue. Being scientists, they started looking at it under the microscope and interestingly enough they found bacteria, viruses, and parasites! The methylene blue stain allowed them to see things more clearly under the microscope.
Another interesting thing that happened while looking at the stain was that they were able to identify a parasite that causes malaria and note that it was killed. The stain had killed the parasite! So actually, methylene blue was one of the first drugs and definitely the first antibiotic, developed in the late 1860’s. They also treated UTI’s (urinary tract infections) with Methylene Blue.
Since then, it’s mostly been replaced by other antibacterials and malaria medicines. In fact, hydroxychloroquine (which is used for many things including Covid-19, Malaria, Rheumatoid Arthritis, and Lupus) is actually derived from methylene blue.
Methylene blue is beneficial for virtually all types of chemical poisonings. It’s a great antiviral, especially when used with red light therapy. It improves breathing, which makes it VERY USEFUL FOR COVID.
Other uses:
- To help with energy (most common)
- To fight depression
- To help with Dementia
- To help prevent and treat UTI
- To help with pain (especially neuropathies)
How it Works
Methylene blue works by increasing mitochondrial respiration. We’re talking about cellular metabolism, which may be the cause of many diseases (along with inflammation).
Methylene blue has to do with the electron transport chain. It actually can donate or receive electrons. If you’ve studied chemistry, think about redox reactions. It’s one of the few things that can donate electrons or take them up when needed for mitochondrial dysfunction.
The mitochondria are those energy producing parts of each cell that produces ATP (i.e., energy) by a process called oxidative phosphorylation. Methylene blue inhibits NITRIC OXIDE.
A good 2021 review of methylene blue reported that it’s the only drug known to inhibit excessive production of reactive oxygen species (think cytokine storm). It’s a low cost dye with antiseptic properties and properties that are used to treat malaria, UTIs, septic shock, and methemoglobinemia.
Note: Methemoglobinemia is a condition where your hemoglobin (which contains iron) is contained in your red blood cells, becomes oxidized, and can’t transport the oxygen. Think carbon monoxide poisoning and cyanide poisoning. Methylene blue turns those patients around really quick because it converts methemoglobin to hemoglobin, and hemoglobin carries the oxygen to all of your tissues.
Contraindications and Dosing:
BEFORE TAKING METHYLENE BLUE …
If you’re on a SSRI (like Prozac or Zoloft) you probably want to wean off that first.
You probably don’t want to use it in pregnant or nursing patients, or babies.
You don’t want to use it if you have that rare G6PD deficiency that we check for if we’re using high dose IV Vitamin C.
Note: At normal doses of methylene blue you don’t need to check for G6PD, but if you’re going to use it for other things (like cancer) and use it in higher doses, you do want to check a G6PD test.
Methylene Blue also:
Decreases your estrogen if you are estrogen dominant.
Decreases prolactin.
Decreases cortisol.
Decreases nitric oxide (which we add back in)
Increases testosterone a bit.
Increases your dopamine and serotonin.
