#21

My weekly figures vary quite a bit from week to week.

#22

High uric acid generally tends to accumulate in joints, skin and veins. Like gout, tophus nodules on the skin. It can even be extremely harmful to the kidneys, and can even lead to uric acid nephropathy. In my opinion, uric acid is not something beneficial for longevity like homocysteine.

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#23

I’m going to track this, hopefully it helps raise my uric acid levels to the desired range:

Bempadoic acid may increase the uric acid levels in the blood (hyperuricemia), which can lead to gout. This can occur within 4 weeks of using this medicine.

Source: Bempedoic Acid (Oral Route) Side Effects - Mayo Clinic

相关：

Untangling the relationship between bempedoic acid and gout: results from a systematic literature review

Bempedoic acid (BA) is a small-molecule first-in-class of inhibitor of ATP citrate lyase that significantly lowers low-density lipoproteins cholesterol (LDL-c) in statin-intolerant and inadequate responders. Increased serum uric acid (SUA) levels and gout incidence have been described in BA-treated patients. The aim of this systematic review was to investigate the safety of BA regarding SUA levels and gout in randomised controlled trials (RCTs).

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#24

In the abstract, the authors say that it is a hypothesis, which in math is stronger than a conjecture but not proven.

#25

Thank you for posting that.

Interesting opinion from Attia to UA: Do NOT go after blood pressure until you’ve got the uric acid below 5.

My current UA level is 6.2mg/dl. I have started low dose bempedoic acid (90mg - every day) and empagliflozin (6mg - only for AMPK days with cardio). Interesting to see, where I will land with my serum uric acid levels.

1 Like
#26

Was the idea that the BP meds might not be necessary after you get Uric acid down?

#27

I am curious … my uric acid is currently 0.43mmol/L… is that 0.77mg/dl? And I thought my uric acid level is very high??? What is the target range? I think I need help with the conversion :joy:

#28

Start with tadafil (aka viagra) … 5mg everyday for 4-5 days a week.

#29

This seems a good convertor

https://unitslab.com/node/51

It makes 7.22mg/dL from 0.43 mmol/L (or 430 μmol/L)

I think of over 400 μmol/L as being on the high side. Around 300 μmol/L is probably around the sweet spot.

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#30

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Testosterone deficiency (TD) is a globally recognized health concern, closely linked to disruptions in uric acid and lipid metabolism. Recently, the uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a comprehensive index for assessing the impact of inflammation and metabolic disturbances on disease risk. Therefore, we intended to explore the association of UHR with total testosterone levels and the risk of TD among US male adults.

Uric acid (UA), a byproduct of purine metabolism, plays a dual role in the body. At physiological concentrations, it acts as an antioxidant and anti-inflammatory agent. However, when elevated abnormally, it triggers chronic inflammation and oxidative stress, which may contribute to various diseases [13, 14]. Uric acid-induced high oxidative stress leads to increased insulin resistance and reduced insulin sensitivity, which in turn results in decreased synthesis of sex hormone-binding globulin (SHBG) in the liver [15].

Normal testosterone levels in men range from 300 to 1000 ng/dL, while testosterone deficiency (TD) is defined as levels below 300 ng/dL and is associated with specific symptoms [7]. TD is a prevalent condition among men, with incidence increasing with age and certain common diseases, such as obesity, diabetes, and hypertension [8]. In the United States, 20–50% of men are affected by TD, with approximately 500,000 new diagnoses each year [9]. As a global health concern, TD presents not only common sexual symptoms like erectile dysfunction, decreased libido, and difficulty achieving orgasm but also serious nonsexual symptoms, including obesity, depression, decreased bone mineral density, and cardiovascular diseases (CVD), all of which negatively impact a man’s quality of life [1, 10, 11, 12]. Therefore, investigating modifiable risk factors to mitigate the incidence of TD, is critical in improving the long-term prognosis for patients and enhancing their quality of life.

Conclusions

The study indicates that, among adult males, higher UHR is negatively correlated with total testosterone levels and positively associated with the risk of TD. This suggests its potential value for early disease diagnosis and intervention. However, further clinical studies are needed to validate these findings.

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#31

See tables in the link below, for veg, meat and fish.

Shiitake, sardines, and monkfish liver (twice the level of sardines) are the top scorers.

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#32

That, of course, just really discourages me… I knew it, but I don’t like it; it just doesn’t seem fair.

Luckily sardines at the level of one 4 oz tin a day or less doesn’t seem to make much difference in my uric acid levels. When you add in pulsed SGLT2 inhibitors I still struggle with too LOW a Uric acid level.

1 Like
#33

Interesting article. I wonder if taking uric acid lowering drugs would increase total testosterone? Seems unlikely to me, what would be the mechanism?

#34

According to AI, the purines in those vegetables don’t have the same effect on gout as the purines in some seafood, organ meats, and beer. They are metabolized differently and don’t increase uric acid.

2 Likes
#35

Does someone know here is ultra low uric acid is problematic? Mine is 15mg/L, or 89 umol/L, wich is really below lab range. Always has been.

#36

Ugh, I didn’t realize low is potentially a problem?

It seems I’ve only had mine tested once, and it was recently 3.0 mg/dl. I will note that my doc did not think that was a problem.

The acceptable range according to labcorp is 3-7.2. Below 6 for gout

I wonder if my taking colchicine lowers it also.

I’m going to get my tsh and vit d tested today… maybe I should tack this on?

#37

I think it is one of those things where very low can be an issue, but this probably varies from person to person.

1 Like
#38

Checking Chat GPT on Low Uric Acid levels and any health implications:

Low uric acid levels (hypouricemia) are uncommon but can be associated with various health problems. While mild hypouricemia may not cause significant issues, persistently low levels can be linked to the following conditions:

1. Kidney and Urinary Problems

  • Impaired Kidney Function – Low uric acid may indicate underlying kidney problems, such as Fanconi syndrome, where the kidneys fail to properly reabsorb essential nutrients.
  • Increased Risk of Kidney Stones – Paradoxically, low uric acid (especially due to xanthinuria, a rare genetic disorder) can lead to xanthine stone formation, which is harder to detect and treat than uric acid stones.

2. Neurological Disorders

  • Multiple Sclerosis (MS) – Some studies suggest a link between low uric acid and an increased risk of MS, possibly due to reduced antioxidant protection.
  • Parkinson’s Disease – Low uric acid levels have been associated with a higher risk of developing Parkinson’s, as uric acid helps neutralize oxidative stress.
  • Cognitive Decline and Alzheimer’s Disease – Since uric acid functions as an antioxidant, very low levels may contribute to neurodegeneration and cognitive impairment.

3. Metabolic and Genetic Disorders

  • Xanthinuria – A rare genetic condition where the body cannot convert xanthine into uric acid, leading to muscle pain, kidney stones, and potential kidney damage.
  • Wilson’s Disease – A disorder of copper metabolism that can cause low uric acid levels along with liver and neurological issues.
  • Hypoparathyroidism – Low uric acid may be seen in disorders affecting calcium and phosphate metabolism.

4. Muscle and Fatigue Issues

  • Exercise-Induced Myopathy – Some cases of low uric acid have been linked to muscle fatigue and weakness, potentially due to metabolic imbalances.
  • Lesch-Nyhan Syndrome (Rare Cases) – Though typically associated with high uric acid, some variations can lead to impaired uric acid production.

5. Oxidative Stress and Antioxidant Deficiency

  • Uric acid acts as a natural antioxidant. Chronically low levels may make the body more susceptible to oxidative damage, which can contribute to inflammatory diseases and aging-related conditions.

6. Medication and Drug-Induced Issues

Certain medications can cause low uric acid levels, leading to side effects such as increased fatigue, kidney dysfunction, or altered metabolism:

  • Diuretics (e.g., furosemide, thiazides) – Can increase uric acid excretion.
  • Aspirin (Low Doses) – Can reduce uric acid reabsorption.
  • Allopurinol or Febuxostat – Used to treat gout but can sometimes cause excessively low uric acid levels.

Should You Be Concerned About Low Uric Acid?

While low uric acid is not always a direct cause of disease, it can be a sign of underlying metabolic or kidney issues. If you experience symptoms like muscle weakness, neurological changes, frequent urination, or kidney stones, it’s best to consult a doctor to evaluate potential causes.

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#39

Thank you. Because I have an apoe4 and lots of neurodegernative disease in my family, I guess I’m concerned low levels might be related.

I don’t know yet if trying to raise levels is helpful in this case. I did see, according to perplexity, the colchicine I’m taking does not lower levels.

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#40

Perhaps consider raising uric acid levels via some healthy foods? (choose those you like from below, avoid those that are not so healthy).

If you’re looking to increase uric acid levels, you should focus on foods that are rich in purines, as they break down into uric acid in the body. Here are some foods that can help:

1. High-Purine Animal-Based Foods

  • Red Meat – Beef, lamb, and pork contain high levels of purines.
  • Organ Meats – Liver, kidneys, and heart are particularly rich in purines.
  • Seafood – Sardines, anchovies, mackerel, herring, shrimp, and mussels have high purine content.

2. Protein-Rich Foods

  • Poultry – Chicken and turkey contain moderate-to-high purines.
  • Eggs – While lower in purines, eggs provide protein that supports overall metabolism.

3. Legumes and Plant-Based Sources

  • Lentils, Chickpeas, and Beans – Moderate sources of purines that can help increase uric acid.
  • Spinach and Mushrooms – These vegetables contain purines, though they are less likely to cause health issues compared to animal-based purines.

4. Dairy Products (Mild Effect)

  • Full-Fat Dairy – Cheese, whole milk, and yogurt may have a slight effect on uric acid levels, though they are generally considered safe for most people.

5. Sugary and Processed Foods

  • Fructose-Rich Foods – High-fructose corn syrup found in sodas, processed snacks, and fruit juices can increase uric acid production.
  • Honey and Table Sugar – High consumption can contribute to raised uric acid levels.

6. Alcohol

  • Beer and Liquor – Contain purines and increase uric acid production while also impairing its excretion.
  • Wine – Has a lesser effect compared to beer but can still contribute to increased levels.

Should You Be Concerned?

While increasing purine-rich foods can raise uric acid levels, excessive intake may increase the risk of gout and kidney stones. If you’re trying to balance uric acid levels for health reasons, consult a doctor before making major dietary changes.

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