#42

btw, they may potentially be of interest - meal timing may impact SHBG

#43

@AlexKChen saw that you say this on your cr society page:

ā€damnit, I donā€™t have that high SHBG. I always thought I had unusually high levelsā€ā€

Does this mean that you feel that high SHBG might be good for (or a good marker of) longevity phenotypes?

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#44

@ConquerAging is always Johnny on the spot with relevant information.

2 Likes
#45

Been looking into this a bit and it looks like a possibly good reward to risk play for a lot of things, see eg below.

What brand and form of boron did you choose? Anyone else have a preferred form?

Did you have any corcerns about unknown side effects from the 10mg/day? (May I ask what your body weight is?)

Boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the bodyā€™s use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as hs-CRP and TNF-Ī±; (6) raises levels of antioxidant enzymes, such as SOD, catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves brain electrical activity, cognitive performance, and short-term memory in elders; (9) influences the formation and activity of key biomolecules, such as SAM-e and NAD+; (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and effects of traditional chemotherapeutic agents. Americansā€™ daily dietary intake of boron was estimated to be approximately 1 mg/d in 199

In none of the numerous studies conducted to date, however, do boronā€™s beneficial effects appear at intakes of less than 3 mg/d. No EARs or DRIs have been set for boron; only a UL of 20 mg/d for individuals aged 18 years or older. The absence of studies showing harm in conjunction with the substantial number of articles showing benefits support the consideration of boron supplementation of 3 mg/d for any individual who is consuming a diet low in fruits and vegetables or who is at risk for or has osteopenia; osteoporosis; OA; or breast, prostate, or lung cancer.

#46

I am a 53yr male, 6ā€™ tall. I was about 200lbs at the time I was taking 10mg/day. (Iā€™ve lost 75lbs since last November, maintaining 188lbs the last couple months). I did not particularly have concerns about side effects as I had researched that dose is generally safe. Also, it was short term as I rechecked labs and felt the desired effect of lowering my SHBG was not achieved. I still believe boron is generally a good supplement so I continue to take it at 3mg/day.

I was taking this; a chelated form of Boron. Boron Glycinate or the brand name ā€œAlbionā€™s Bororganic Glycinateā€.

Pure TheraPro Rx Bio Boron, 10mg/Capsule, 90 Capsules, Bororganic Glycine Boron Supplements for Men & Women, Vegan Mineral Supplements for Bones, Cardiovascular Function & Immunity Support https://a.co/d/e0Arpfs

I have since switched to others such as Life Extension Boron complex which is a mixture of Boron Citrate/Aspartate/Glycinate. I just added to my stack this week Thorneā€™s PIc-mins which is a multi-mineral with all of the included minerals in the picolinate form. It includes 700mcg of boron picolinate. So currently I take 3.7mg of Boron in a mixture of 4 different forms. I wish I had lab results to share before starting pic-mins but it will probably be another month before I test again.

#47

Thanks a lot Stealle

Have you (or anyone else) tested for boron levels? (Or are you talking about SHBG)

How about you @John_Hemming @AlexKChen ?

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#48

Sure! I hope something there was helpful.

I have not tested boron. I might consider that though. I would also like to test zinc and copper. Iā€™ve been supplementing with zinc for quite sometime which can cause copper deficiency. Iā€™m reluctant to supplement with copper as I believe copper has a narrow therapeutic index. Iā€™ve been meaning to eat a handful of pistachios every once in awhile because I love them and they are quite high in copper but I keep forgetting. Iā€™ve been avoiding them for so long because they are high calorie and I was trying to loose weight.

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#49

I was very happy with this test. Cheap and seemed right:

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#50

Thanks a lot for info. Did you research itā€™s accuracy in anyway?

#51

Interesting. Just curious, did you have results that required diet or supplement changes? If so, did you retest after some time later?

#52

I have not redone the test but probably should.

The only thing that sticks out was that some radioactive metal (zirconium?) showed very high and it was a head scratcher because where did that come from? It turned out that Radon shows up as zirconium. So we got the house tested and it was pretty high. This was after raising 5 kids here. Oops.

I also remember sodium was very high and potassium was very low. I started using a blended salt. I think copper and zinc were on the low side and I started supplementing them as well.

We shed minerals into the hair at a regular and predictable rate, they figure out the rate and just dissolve your sample and run it through the machine. So the labor is pretty low, thus a cheap test. I thought it was worthwhile. Made me feel good about not having too much lead or mercury too.

Not supposed to use shampoo for a few days to avoid contamination, and you end up with small patches of hair gone. Might bother some peopleā€¦not me.

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#53

Oddly enough I did a hair test recently which included Boron. I looked it up in that and was in the bottom end of the reference range. That is enough for me to continue at 3mg per day. I am not going to study Boron any further because my current focus is on mitochodrial efficiency (primarily) and mRNA transcription.

To me Boron is one of those things to get into a good range and then forget about it. I donā€™t think it needs cycling. I just think it needs to be there. Similarly with Lithium - allthough the hair test on Lithium has me high although serum is under 0.05 mmol/L and my target is actually to be just under or on 0.05mmol/L.

Again I donā€™t think Lithium needs cycling.

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#54

Cocoa is good for copper as well. Alcohol and B5 are bad for copper.

#55

I just learned of the connection of copper to iron overload. This might be interesting.

ā€œ this may not be the whole story, as was recently suggested by longtime copper researcher, Dr. Joseph R. Prohaska (Univ. of Minnesota, Duluth) (22). Copper depletion also reduces CP activity in humans, leading to hepatic iron overload and thus increasing risk for oxidative damage and liver cirrhosis (14).ā€

Copper.

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#56

I think the depletion of copper is an issue when it comes to the creation of new RBCs. One of my issues has been a high MCV. This arose in part from me drinking quite a bit which caused copper depletion.

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#57

Dumping iron today. (Donating blood).

4 Likes
#58

Ok, my boron is arriving today :slight_smile: Any experiences around how it impacts sleep positively or negatively?

Trying to decide on whether to take at dinner/before bed or rather in the morning/around lunch?

#59

Bryan Johnson has a high SHBG and seems quite happy with it.

Alex - see also chain above.

Anyone else have thoughts?

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https://twitter.com/bryan_johnson/status/1732484916619997503?s=46&t=zJMJ1xVdRJYEDYz-DHipTw

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#60

What has this got to do with iron?

#61

I think it started with the above, but then there were something like 35 entries above about SHBG on this thread (in a rich way):