Hi Amira, yes, there’s definitely a link with diet. I have found wheat products at night make the condition worse. But it’s a good idea for me to test foods more specifically. I typically don’t eat too late, usually done by 8pm. Lunchtime doesn’t matter, it’s only dinner, maybe there’s some circadian influence on asthma onset as well.
1 Like
12/4 update: just one puff again last night, I’m surprised and thrilled with how effective this has been, especially with just 1mg rapamycin dose.
Going forward I will only update 1/week unless there’s a drastic change in outcomes.
12/7 and Week 1 update.
Asthma slowly came back over the course of the week, likely coinciding with rapamycin leaving my system. I took 2mg this morning (12/7 around 8am) and will report back next week on the asthma impact.
A few notes on the chart below:
- Fasting is also effective at reducing asthma episodes for me, but it usually only lasts the day of the fast (11/30 this past week). To avoid confounding factors, I will not fast for the next few weeks.
- This is simply tracking the number of times in each day that I use an albuterol inhaler (each puff). Early morning albuterol use is accounted for in the prior day’s tally, e.g. if I take a puff at 4am on 12/5, that is in the count for 12/4. I do this because my asthma episodes mostly emerge at night, and I’d rather keep all the episodes over each night in the same day for tracking purposes.
1 Like
Been on rapamycin 6mg once weekly for months. I stopped the rapamycin temporarily in order to compare my CGM readings with and without the weekly rapamycin. I have not had a flare-up of asthma in years but I awoke in the middle of the night due to wheezing and had to find an old albuterol (rescue) inhaler. I never expected that! I associated it with the temporary (3 wk) cessation of rapamycin. It’s not that rapamycin stopped my asthma attacks, but curiously, stopping the rapamycin may have induced one.
1 Like
Dr.Bart
#16
As a physician that specializes in asthma, I would be very careful here:
Several points to consider; NOT MEDICAL ADVICE.
- Asthma treatment is typically catered to its phenotype.
- It’s extremely unlikely that rapamycin would achieve immunosuppression high enough to suppress inflammatory bronchitis at 1 mg a week, and if you ever achieve this degree of systemic immunosuppression I would worry about systemic side effects - increase chances of infection (bacterial or fungal), mucosal atrophy, etc.
- There are 3-5,000 deaths a year in US from asthma and it occurs equally in all types of severity.
- Placebo effect is HUGE in perceived asthma symptoms, better way to track asthma progress would be to use exhaled NO or spirometry. At home I would use serial peak flow meter measurements. Objective >>>>>>>>>>>>>subjective.
- Asthma is characterized by its ability to quickly revert back to normal lung function in most people when stimulus for exacerbation is removed or mitigated - air pollution, infection, allergy etc.
- New asthma guideline allow for AS NEEDED use of inhaled steroid usually combined with B2-agonists - my preferred way to treat intermittent or mild persistent asthmatics.
- I have seen many cases where asthma presents along with misdiagnosed vocal cord dysfunction.
- I had many patients with asthma that were able to stop continuous use of inhaled steroids with allergy desensitization, restoring nasal breathing, avoidance of allergen or irritant, addressing GERD, etc. etc. etc.
3 Likes
Dr. Bart, thank you so much for taking the time to give such a thorough reply. A couple of follow-ups:
- It’s extremely unlikely that rapamycin would achieve immunosuppression high enough to suppress inflammatory bronchitis at 1 mg a week…
Yes, I suspect my results were largely due to fasting, which has always improved my asthma symptoms; and less by rapamycin. Or maybe it was the combination of fasting and rapa that had such marked improvements. This week I did not fast and the impact of rapa (2mg) on asthma is less pronounced.
- Placebo effect is HUGE in perceived asthma symptoms, better way to track asthma progress would be to use exhaled NO or spirometry. At home I would use serial peak flow meter measurements.
Agree, I have a peak flow meter somewhere, I’ll try to find it or order a new one. I was hoping # of albuterol puffs was objective enough, but maybe not.
- Asthma is characterized by its ability to quickly revert back to normal lung function in most people when stimulus for exacerbation is removed or mitigated - air pollution, infection, allergy etc.
We’ve been trying to find the stimulus for a long time, so far no luck. Using hypoallergenic material wherever possible and reliable air purifiers too. We recently ordered a new mattress in case that is part of the triggers, though the one we have is wrapped in an allergy barrier. I would like nothing more than to manage asthma by reducing environmental triggers.
- New asthma guideline allow for AS NEEDED use of inhaled steroid usually combined with B2-agonists - my preferred way to treat intermittent or mild persistent asthmatics.
Doctor prescribed inhaled steroid, and those worked great at controlling my asthma. Any thoughts on adverse long-term use of inhaled steriods? I got a very bad case of shingles while using them and was concerned there might be a link.
- I had many patients with asthma that were able to stop continuous use of inhaled steroids with allergy desensitization, restoring nasal breathing, avoidance of allergen or irritant, addressing GERD, etc. etc. etc.
I asked for allergen testing and to my surprise, all the major ones (dust, dander, etc.) came back negative. As a kid, I had very severe allergies to dust especially, and did some desensitization. GERD is an interesting one, I’ll look at it more closely, but generally my digestion feels okay.
Dr.Bart
#18
Herpes Zoster is typical for you age. I have never seen a correlation between steroid use topical or systemic and shingles.
Dust mite allergy can be entopic - google it.
GERD can be silent - google it.
1 Like
Before I developed asthma last year I used to fast regularly. Now I find that when I fast my breathing becomes much worse very quickly. As albuterol inhalers don’t help me, I haven’t been able to fast. Oral prednisone is the only way I can control asthma so no fasting.
When I fast i feel great, calm and full of energy. So even as I am feeling the positive effects my breathing is getting worse, forcing me to stop.
I have tested negative for allergies btw.
Tbh I haven’t noticed any positive effects from 2 months of taking 2mg of rapa every week with grapefruit juice.
2mg rapa once a week with grapefruit juice
1000 mg metformin every morning.
No matter what ai eat or don’t eat, my asthma symptoms increase after about 8pm. Then decrease in the morning.
As albuterol doesn’t help me this means sleep is difficult. I feel great but by the time I want to go to bed I have shortness of breath.
Sometimes I need to drink a strong coffee to get to sleep.
daver
#22
Amira, have you tried getting rid of your asthma entirely with azithromycin, under a doctors care
of course. There’s a protocol, and it completely cured my asthma of 20 years. I had been taking
250 mcg of fluticasone twice a day but was unable to get by on 125 mcg. Recently I ran into a
friend from the past who told me it cured his asthma too, but for him it came back after a year
and he’s now about to repeat the protocol. This is all described in the book, “A Cure for Asthma?”
which is available on Amazon. As high as 50% of people might be cured, usually those with
the asthma most difficult to control, For me, I added N-Acetyl cysteine and some colloidal silver
to the protocol because I think those things make antibiotics work better.
2 Likes
daver
#23
In any event, I would encourage you to take as much vitamin D (along with vitamin k2 and
magnesium) as is safe, as I believe it can help prevent lung damage. There’s even an
unsubstantiated idea that the Coimbra Protocol can stop all asthma as long as you’re on it.
This is not a recommendation though.
1 Like
That’s interesting, thanks. I’ll look into Azithromycin.
I’m taking 5000 IU of D3 with MK7 a day (and magnesium), I was taking double that dose for a few months, but I got scared into lowering it.
I also tried the Russian fasting method, but every time my symptoms became so bad I had to stop by day 11 at the longest.
I have a diet free from seed oils, wheat and sugar. I don’t have any allergies. I was also a long distance runner until I got asthma last year. My lung capacity is still at the average for a 20 year old (I’m in my 50s) when my lungs are clear, which is only with prednisone now.
The doctors want me to start a biologic (monthly injection) to supress the eosinophils next month, as I’m diagnosed with late onset, steroid-dependent, severe eosinophilic asthma, which doesn’t respond to inhalers.
I’m a bit worried what the long term effects of that med might be, but at this point I’m desperate. Also I need to get off prednisone dependency.
As it all started after a mild bout of COVID and I’m basically very healthy, I still feel there is some way to reset this.
They gave me lots of tests to rule out other diseases.
The Coimbra diet looks interesting. I think I’m going to give that a try, I’ll let you know how it goes.
This apparently is me, on the right, nonallergic SEA.
1 Like
Dr.Bart
#25
I would inquire about Tezspire, it blocks TSLP which is higher upstream of the inflammatory pathway.
1 Like
There may be something to the bacterial theory of asthma. When I was a child, I had frequent lung infections with associated asthma. In college and as a young adult, my asthma more or less disappeared, even though I had lung infections fairly frequently. Then I had kids, and one of my sons had a very high fever when he was about 2 years old, and I had to get him to a doctor urgently (ended up being a bacterial infection if I remember correctly). I had a lung infection at the time and didn’t have access to a car, so I biked as fast as I could with my feverish son in tow. My asthma started back-up after that incident and has been with me ever since.
I’ll take a look at that book, thanks for the recommendation.
(Late) update, week 2.
I’m not sure how responsive my asthma is to sirolimus. I take other supplements that may be more impactful, like Berberine and Quercetin. I stopped taking those 12/11, but it’s hard to isolate any one impact. I’m coming to the realization that N1 experiments are kind of useless, but I’ll keep going for a few more weeks and see if anything interesting comes up.
2 Likes
Yeah, but let’s be honest, many of us here are taking powerful medications based on the beneficial impacts seen in mice in antiseptic labs; and based on subjective anecdotal reports from other N1. I would prefer people encourage and report on their N1 results so we can start to get a sense of what works and what doesn’t. Hopefully we will soon have reliable data from well-designed studies support some of what we are experimenting on in this forum.
Update week 3.
Asthma seems to have gotten exacerbated with 4mg rapamycin. This was followed by lower incidence of asthma in the next few days. @PLEIADES reported on a similar effect here.
I decided to continue taking quercetin and berberine, which may have a role in reducing asthma attacks. Obviously these are big confounders, but right now I’m more interested in getting asthma under control without steroids than being a purist about isolating the impact of rapamycin.
Lastly, came down with a cold and will be getting my shingles vaccine in a few days, so no rapaymcin this week.
Update week 4.
As mentioned in the last update, no rapamycin this week due to an infection and getting the shingles vaccine a few days ago. I will wait until this infection clears before starting again.
Good news on controlling asthma, taking GlyNAC in the evening (started 12/25) has removed the need for the nightly puff. There is weak evidence that NAC can be useful in the treatment of asthma; and even less evidence for glycine. Nevertheless, taking GlyNAC at night has completely cleared my nocturnal asthma 
I’ll report 1 more week to confirm the GlyNAC effect is persistent.
1 Like
