I think so too…high potency directed delivery to the brain without resorting to immunosuppression/metabolic dysregulation of periphery with high oral doses? I would still do periphery dosing (w blood panels, sirolimus monitoring), but perhaps more conservative.
Agreed. I have 4 grams of powder, a lucky benefit for this exploration.
Yes always. The mass spec/HPLC didn’t indicate any obvious negative signal, but risk to everything. I might be more at risk eating a grilled beyond meat burger or driving in the polluted toxic air of a big city.
“Nitrosamines can be found in a wide variety of foods, such as beer, salted fish, non-fat dry milk, cured meats like bacon and hotdogs, and cheese, agricultural chemicals like fertilizers, tobacco products, detergents, rust inhibitors, cutting fluids, rubber additives, solvents, drugs, plastics, tanned leather products, textiles, and cosmetic products.”
“PM from central London over two periods in winter and summer. The average total nitrosamine concentration was 5.2 ng m−3, substantially exceeding a current public recommendation of 0.3 ng m−3 on a daily basis. The lifetime cancer risk from nitrosamines in urban PM exceeded the U.S. Environmental Protection Agency guideline of 1 excess cancer case per 1 million population exposed after 1 h of exposure to observed concentrations per day over the duration of an adult lifetime. A clear relationship between ambient nitrosamines and total PM2.5 was observed with 1.9 ng m−3 ± 2.6 ng m−3 (total nitrosamine) per 10 μg m−3 PM2.5.”
We all have our risk/reward equations. I’m liking this new paradigm opportunity to unlock a better pharmacological/longevity benefit of rapamycin.
Now if these guys take VISA? Craniotomy is a no for me.
Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin
https://aacrjournals.org/clincancerres/article/23/12/3045/80046/Noninvasive-Measurement-of-mTORC1-Signaling-with
While we’re thinking outside the box, what about ip injection, far superior to oral? LOL
Comparison of rapamycin schedules in mice on high-fat diet
"Here we demonstrated that i.p. injections of rapamycin prevented weight gain on high fat diet, whereas rapamycin by gavash (also given 3 times per 2 weeks) did not. Orally administrated (gavash) rapamycin has poor bioavailability. The i.p. route of its administration ensures high peak of systemic levels of rapamycin. We can conclude that acute high levels of rapamycin may be necessary to prevent obesity."
" It may seem paradoxical that intermittent administration (by i.p.) is more effective than everyday administration (by oral gavash). One plausible explanation is that at high peak levels, rapamycin may affect cell types that are not sensitive to low concentrations of rapamycin. In fact, the effective concentrations of rapamycin vary broadly in cell lines in culture" (most especially the brain)
Did you say “early” adopters?
