#536

What brand / Mfg do you use for enclomiphene? Are you getting a prescription from your local doctor and buying at a local pharmacy, or buying via India?

#537

Prescribed. Fulfilled by https://www.empowerpharmacy.com/

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#538

What dosage and how much per pill?

A local compounding pharmacy made if for around $110-120 for 60 12.5mg caps.

#539

25mg, 90 capsules for $127.50 including shipping. 5/week was too much (LH/FSH far over the range) so currently testing 2/week.

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#540

That’s awesome. Enclomiphene is likely different to Clomid, as you know. The theory is that the lack of symptom relief with Clomid is likely due to antagonising estrogen in the brain.

Sure. I’m sad enough that I have a spreadsheet of research on this, haha. Though I haven’t updated it for maybe 2 years. Here you go:
Clomid studies.xlsx (15.1 KB)

I did try Clomid for a while as a “test booster” raising my levels from around 300 up to around 700. I did subjectively notice some eyesight issues, so I stopped. I didn’t really feel any different with regards to energy, erections, libido etc.

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#541

Thanks for the sources! I took a quick look at pubmed and found the following.

Clomiphene citrate is an effective therapy for improving both biochemical as well as clinical symptoms of males suffering from hypogonadism. Clomiphene citrate has few reported side effects and good safety aspects.

Improvement in ADAM scores.

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@desertshores linked this above with more commentary

There is insufficient evidence to support the routine use of Clomiphene, tamoxifen, and aromatase inhibitors to optimise semen parameters in men with infertility. Future randomised trials are needed to confirm the efficacy of clomiphene in improving fertility outcomes in men.

Treatment with clomiphene citrate and enclomiphene citrate may be an effective and safe alternative to testosterone replacement therapy in men with obesity-related functional androgen deficiency. Further long-term studies are warranted to define clinical reflections of the selective estrogen receptor modulators-induced increase in testosterone levels and to better clarify the safety profile.

Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism, studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous, preventing this meta-analysis from investigating the efficacy of SERMs on male infertility. The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.

My overall take after reading the sources you provided and some of the above reviews/meta-analysis is:

  1. Unclear whether it helps with fertility issues in men.
  2. Improves ADAM scores, and thus subjectively helps with low T symptoms.

I would strongly suggest that people who feel they have symptoms of low T do the following:

  1. Try Enclomiphene or Clomid, titrating the dose to normalize testosterone and other hormone levels (including Estradiol with an aromatase inhibitor if necessary)
  2. If sex hormones normalized, check other overlapping causes of low T symptoms → depression, anxiety, other hormones (thyroid, adrenal), etc.
  3. If all hormones normalized AND neuropsychiatric conditions are ruled out → start testosterone therapy, ideally alongside Enclomiphene/HCG/Clomid/others to preserve testicular function in case testosterone therapy does not improve symptoms to make it easier to come off.