#536

What brand / Mfg do you use for enclomiphene? Are you getting a prescription from your local doctor and buying at a local pharmacy, or buying via India?

#537

Prescribed. Fulfilled by https://www.empowerpharmacy.com/

1 Like
#538

What dosage and how much per pill?

A local compounding pharmacy made if for around $110-120 for 60 12.5mg caps.

#539

25mg, 90 capsules for $127.50 including shipping. 5/week was too much (LH/FSH far over the range) so currently testing 2/week.

2 Likes
#540

That’s awesome. Enclomiphene is likely different to Clomid, as you know. The theory is that the lack of symptom relief with Clomid is likely due to antagonising estrogen in the brain.

Sure. I’m sad enough that I have a spreadsheet of research on this, haha. Though I haven’t updated it for maybe 2 years. Here you go:
Clomid studies.xlsx (15.1 KB)

I did try Clomid for a while as a “test booster” raising my levels from around 300 up to around 700. I did subjectively notice some eyesight issues, so I stopped. I didn’t really feel any different with regards to energy, erections, libido etc.

4 Likes
#541

Thanks for the sources! I took a quick look at pubmed and found the following.

Clomiphene citrate is an effective therapy for improving both biochemical as well as clinical symptoms of males suffering from hypogonadism. Clomiphene citrate has few reported side effects and good safety aspects.

Improvement in ADAM scores.

image
image1383×196 67.7 KB

@desertshores linked this above with more commentary

There is insufficient evidence to support the routine use of Clomiphene, tamoxifen, and aromatase inhibitors to optimise semen parameters in men with infertility. Future randomised trials are needed to confirm the efficacy of clomiphene in improving fertility outcomes in men.

Treatment with clomiphene citrate and enclomiphene citrate may be an effective and safe alternative to testosterone replacement therapy in men with obesity-related functional androgen deficiency. Further long-term studies are warranted to define clinical reflections of the selective estrogen receptor modulators-induced increase in testosterone levels and to better clarify the safety profile.

Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism, studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous, preventing this meta-analysis from investigating the efficacy of SERMs on male infertility. The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.

My overall take after reading the sources you provided and some of the above reviews/meta-analysis is:

  1. Unclear whether it helps with fertility issues in men.
  2. Improves ADAM scores, and thus subjectively helps with low T symptoms.

I would strongly suggest that people who feel they have symptoms of low T do the following:

  1. Try Enclomiphene or Clomid, titrating the dose to normalize testosterone and other hormone levels (including Estradiol with an aromatase inhibitor if necessary)
  2. If sex hormones normalized, check other overlapping causes of low T symptoms → depression, anxiety, other hormones (thyroid, adrenal), etc.
  3. If all hormones normalized AND neuropsychiatric conditions are ruled out → start testosterone therapy, ideally alongside Enclomiphene/HCG/Clomid/others to preserve testicular function in case testosterone therapy does not improve symptoms to make it easier to come off.
#542

Blsm, You may have already answered this, but what brand of weight vest do you use? I tried one by Apex at 20 pounds, but it was awkward to put on, cumbersome to wear and the straps didn’t have enough insulation.

#543

Currently I have one made by CAP Barbell and bought it because it was affordable and you can add and subtract weight. I like it although it looks quite serious! Hahaha
I had a non adjustable hot pink one but it had weight on the shoulders and one day I hopped on the off road vehicle with my husband, we hit a bump and I got a minor injury to my Supra spinous fossa. I’m fine of course but my shoulders look a little different now!:blush:
I also bought one by Tone Fitness that isn’t adjustable weight wise but doesn’t have anything but material directly on the shoulders for just wearing around the house doing regular activity.

IMG_7094
IMG_70941290×2796 202 KB

1 Like
#544

Hi Joseph, Very good write up, I agree with it, A few things to consider adding:

  1. a Foam Roller (to help with recover)
  2. Urolithin A ? Anyone have feedback on this?
  3. a key one I think you missed is EAA’s (I like them better than BCAA’s)
  4. HMB (maybe)
  5. Turkesterone & Ecdysterone (thoughts?)

Cheers

1 Like
#545

@Denet

Agree with EAA. Need enough but extra might be counter productive. Have to experiment to discover how much is enough (build and retain muscle).

Urololithin A is promising. I have been taking 0.5-1g per day for 2 months. No obvious benefits but its use has coincided with important subjective improvement in vitality and recovery.

1 Like
#546

I’d be interested in hearing more about your experience with enclomiphene. I know people who use it and I’ve seen their personality change for the worst.

#547

I took 25 mg per day, which was too much. Spiked my T to 1100 and made me more abrupt on the phone. Of course I promptly quit. I find the effects of the gel to be quite smooth.

I’ve also been taking febuxostat, which lowers uric acid and seems to eliminate pedema. As a consequence, I’ve started taking 200 mcg of CJC/ipa per day. This has in the past caused my feet to swell, but tentatively speaking, not any more. It compliments testosterone very nicely.

#548

I use 20% cream and enjoy it. I wish you could get the cream from online pharmacies but only gel is available.

CJC/ipa I’ve tried but I didn’t get much. I’m looking to try something like that again, or mk677 or straight HGH.

#549

@blsm, @Jay

I wore a weight vest for four or five years, hoping to increase my speed in the stairwell but never did. I have a built-in speed limit, related to overexertion and overheating. My vest was made of neoprene, which eventually split in several places. Neoprene glue worked for a while.

2 Likes
#550

Did the same vest last you the entire time? I just washed my Cap vest and it fortunately held up well. I’ll probably invest in a higher quality one for my next purchase though.
I recently read a good write up about the latest science on the topic by Michael Easter. It’s behind a paywall but I’m going to see if I can get permission to share it. Apparently there’s something going on that’s been termed a gravistat and it’s communication between certain bone cells and the brain that signals organisms to eat less when under additional weight like using a vest or pack. It explained why I was able to steadily lose weight in the past without really mindfully restricting my food intake much.

1 Like
#551

No, but when the first one fell apart, the company sent a replacement. This was 20 years ago, so I don’t remember the name, but it looks like Amazon has good selection.

#552

Enclomiphene revisited. This was discussed at length previously, but I am too lazy to search the threads.

I tried some Enclomisign, Enclomiphene 50 mg tablets from India in December of 2023. I mistakenly thought I was buying enclomiphene when, in fact, it was just clomiphene.

It turned out it wasn’t pure enclomiphene but rather enclomiphene from clomiphene. In any case, it wasn’t very effective, but I didn’t feel any side effects after taking it for more than a month. Most people are quick to point out any adverse effects, especially on Reddit.

Clomiphene citrate contains:
≈ 62% enclomiphene (E-isomer, anti-estrogenic) and ≈ 38% zuclomiphene (Z-isomer, estrogenic). **It is the zuclomiphene that causes most of the unwanted side effects in males.

“Clomiphene is a blend—effective but carrying the baggage of a long-acting estrogenic isomer. Enclomiphene is the purified “good half,” giving a cleaner hormonal profile, quicker kinetics, and generally fewer estrogenic-type side-effects, but at the cost of FDA-unapproved status and higher price.”

But still, the side effects are experienced by less than 10% of the users.

“The most frequent side effects were mood changes, blurred vision, and breast/nipple tenderness.” "Reported side effects were only prevalent in less than 10% of the study populations, and no serious adverse events were reported.

Since then, looking at IndiaMart, there are now more choices than when I ordered in 2023.
I am going to give it another shot. Some brands claim to be just enclomiphene citrate. Who knows? It’s from India, and one can only hope. Why? Because I want to preserve muscle mass and get a little more energy. Enclomiphene does not affect the natural production of testosterone when you stop taking it. And of course, my doctor isn’t going to help me because my free T is still in the low normal range.

I looked at a meta-analysis of clomiphene.
Clomiphene citrate for men with hypogonadism: a systematicreview and meta-analysis
“https://onlinelibrary.wiley.com/doi/epdf/10.1111/andr.13146”

2 Likes
#553

Good luck with all that. Enclo is certainly superior to clomid.