#221

I was buying a pomello, basically a large grapefruit. and blending half of it the night before Rapa with a little Oj and adding soda water. Makes a great drink and doing the other half the next day. I think it might be overkill as I got side effects with a 3mg weekly dose but the drink is yummy

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#222

I think the grapefruit thing is stupid. Since i stopped the stupid grapefruit and did 5 pills straight nothing just water all my side effects disappeared. I agree with docs thaT SAY GRAPE FRUIT SHUOLD NOT BE CONSUMED WHEN TAKING MEDS. HIT CAP BT MISTAKE. TOO LAZY TO REDO LOL. I think grapefruit interfere in more ways than just bioavailability of the drug us such it should not be consumed when doing drugs.

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#223

Yeah, that is a big dose. I use either 3 or 4 every 2 weeks and it works pretty well.

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#224

it would make sense because with GFJ you are getting a lot more … why not try 15 or 20 pills and see if your side effects return… if so… GFJ is just normal.

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#225

Nah I’m not a fan of grape fruit juice. I think it has other weird stuff that may interfere with meds, not just the fact that it increases the bioavailability and absorption. Plus I hate the taste also. I’ll just do 5 straight pills per week and that should be good.

#226

I wonder if transcutane application with the help of the droplette device mentioned in the “Reverse Gray Hair, Hair Repigmentation](https://spotify.localizer.co/t/reverse-gray-hair-hair-repigmentation” subject or via sublingual administration both bypassing the entero-hepatic pathway could give higher bioavailability.

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#227

I take my rapamycin sublingually, but I have to do an extraction on the tablet/s first to remove all the inert components.

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#228

John - interesting. Have you done any blood testing to know how well the sublingual rapamycin is being taken up?

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#229

I haven’t done any blood testing for drug levels. Unfortunately I live in the UK and my nearest testing centre would be London, and I’m going through what will probably prove to be a messy divorce.

I’ve done everything I can to enhance lingual vein absorption of drug. I’ve reduced the dosing volume down to 120ul of transcutol based dosing solution by extracting the rapamycin from the tablet.

I’ve also maximised contact time with the vein by applying a 10ul droplet to each lingual vein every 30 seconds, with my head back and tip of tongue touching the roof of my mouth.

I have in the past also added 5ul of a food colouring dye to the dosing solution and there doesn’t appear to be any pooling at the base of the tongue.

I love to know what my drug levels are using this dosing technique. I have tried to buy an ultra sensitive Rapamycin ELISA kit but unfortunately the company won’t sell to a private individual.

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#230

Meta Analysis of Rapamycin enhancing strategies.

States multiples for Ketaconazole, GFJ and half life of Rapamycin.

This answers lots of questions about Rapamycin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410974/

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#231

A lot of reading. So the peak is around 2.2 hours. I can definitely feel the effects after 2 hours. One thing on the positive side my nose that usually suffers from allergies no longer seems to get that any more.

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#232

What I meant is if you increase your pills without GFJ… see if the effects return. If it returns then it is just normal. I personally do not like to consume more “medication” than necessary… I rather use other means to boost the strength.

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#233

That sounds like quite the chore to do all that. Have you ever tried to just put the pill under your tongue and let it dissolve. I assume it will dissolve slower because of the coating but by the looks of it, it should disolve? .

#234

@DeStrider This is very helpful. Thank you.

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#235

assuming 1 grapefruit is 6x
would 1/2 grapefruit be a 3x multiplier.

e.g. 1mg with half grapefruit=approximately 3mg

What is a good way to mimic a 3mg dose.

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#236

I have seen in no studies on how the fruit impacts bioavailability, so I would not assume anything, or even venture a guess. In the past I’ve used 1 grapefruit two hours prior to taking the rapamycin and I’ve assumed its approximately equal to one 8 ounce glass of GFJ, but I don’t have any data to support that assumption. Perhaps if you squeeze a grapefruit and see how much juice you can get from it you have slightly better information.

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#237

I have never seen a grapefruit giving 6X. The standard assumption is 3X at maximum inhibition of CPY enzymes. If you don’t take enough GFJ, you can assume less than a 3X multiple.

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#238

No, your assumptions can’t possibly be right. Once you get enough grapefruit to suppress that enzyme (don’t know the name, and too lazy to search its name) then you could eat 15 grapefruits if you like, and the effect would still be the same. Let’s say the enzyme is blocked with 1/2 a grapefruit and that would give you 3X (this I think can vary from person to person and other variables) then even five grapefruits would still give you 3X.

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#239

It would be interesting to have some kind of protocol to take 1mg Rapamune only while mimicking 2,3,4,5 and 6mg via other means (not necessarily GF only).

Maybe by monitoring side effects to gage strength?

e.g. would 2mg taken with a meal or fat increase by 30% therefore making it similar to 3mg.
How could this be achieved while only taking 1mg.

It’s most likely too difficult to accurately determine as different people respond differently to both Rapa and Rapa/GFJ combination.

#240

I posted before. 5mg with GFJ on an empty stomach, no olive oil is tolerable.
6mg with GFJ produces diarrhea the next day. I have repeated this experiment enough times that I know the max dose for me is 5mg with GFJ,

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