#101

I can confirm that Dr. Green still recommends 6 MG, still prefers weekly dosing, and does not give any recommendations about taking with food. I know he would disagree about adding GFJ (ditto Matt K) but that never came up. I have started taking mine with fatty foods based on what I have read on this site. There may be benefits to a higher dose, but an improved immune response does not seem to be one of them. Five MG performed much better than 20 MG.

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#102

Exactlyā€¦I do 6mg ā€¦GFJā€¦ Steakā€¦ once a week.
GFPā€¦ in me is 5 times strength 30 ng/mL

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#103

Zazim, could you please elaborate on this statement? How is it much better?

#104

Itā€™s all available in the Mannick paper though they used Everolimus not Rapamune which is ~80% as effective:

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#105

And like all rapalogs ridiculously more expensive, but the results are valid for our conversation. Peter Attia has a good podcast with the lead author on this paper and also one with Joan Mannick.

#106

Actually everolimus is now generic and about the same price as rapamycin. Easily available from the regular Indian online pharmacies.

#107

Yes, but resTORbio seems to be focusing on RTB101 which isnā€™t generic.

#108

If the Mannick paper (which showed mTOR inhibition improves immune function in the elderly) is being used as the framework for rapamycin dosing, shouldnā€™t we be using bi-weekly dosing of sirolimus instead of weekly, given that the half-life of sirolimus is roughly double that of everolimus (aka RAD001) used in the Mannick study?

#109

I tried Dr. Greenā€™s formula for rapa cream. (.045%) Mixed two batches of Cetaphil cream 200 grams + 90 mg. Rapa, and I liked the results. This is what Green used on himself with good results on sun damage to head and face. This time around I am adding propylene glycol to enhance absorbtion. Transcutol is controlled where I live in EU. Propylene glycol is used extensively in cosmetic industry, to promote absorbtion, and has a safe profile. So my new formula is 200 grams Cetaphil cream + 90 mg Rapa powder disolved into 2 oz. propylene glycol all mixed well. After mixing, I could have probably used 3 oz Propylene glycol instead of 2. (experimeting on how much Propylene glycol to use per 100 grams of cream) I am expecting very good results. I should say that using tablets can be expensive for some, but powder is the best way for all rapa uses, oral, IM, IN, and topical.

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#111

ResTORbio closed up shop and sold the assets after the second clinical trial didnā€™t meet the modified FDA end goals for the phase 3 clinical study. Iā€™m not sure who purchased the IP, if anyone.

#112

Tornado therapeutics (Joan Mannickā€™s company) licensed them. Still moving forward it seems.

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#113

I have heard about this study so muchā€¦- it is constantly referenced. Joan really breaks it down for the layperson to understand. Great post.

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#114

How did using Propylene glycol go? How much did you use in the end for 100g cream? I want to make a DIY rapamycin cream but transcutol isnā€™t available where I live either.

#115

I just use about 1/2 oz to mix the rapa into and then mix that very well with Cethapil cream. Works good

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