It should be good to define a common protocol of tests and biomarkers to be done before and after hbot, such as bryan Johnson did (while often without all technical data such as full raw diagnostic).
I would love to bring this kind of community lead protocol to measure effectiveness and impact of various treatments and therapeutics into the hackingbiology software project Hacking Biology - Project Presentation - Google Slides .
For each intervention that try to tackle with some action, one or more than one hallmark of aging, to have a proper set of biomarkers and how to collect them and how often, with the software providing guided input for data management, analytics and sharing.
What would be the key the biomarkers to collect and look for, and the ones for differential analysis to be also kept under check for safety?
That’s the kind of answer i’d wish to end up to do, also for the hbot, where I’m reasoning in the question (unfortunately, now have not yet enough time to work on it)
Fabio
I haven’t given much thought or looked much into what would be the best biomarkers to test before and after HBOT. I wish I would have had more time and funds to do more testing before and after I tried a 6 week course of HBOT for a health problem a few years ago. I will say this though. Assuming people are interested in long term benefits not just acute effects, I think it’s important to test the effect of HBOT by doing tests before and some months after finishing the last bout of HBOT. HBOT will influence some parameters during the weeks one is undergoing the HBOT sessions but it’s not so important to know that parameter X increases during those weeks if X if it then goes right back to baseline many weeks after stopping the sesisons. This is different than for supplements or drugs that people take continuously without breaks.
Well, i may argue that HBOT is not just something you do for a series of 30-60-90 sessions, but I’d think to keep it going as part of an ongoing life-long treatment, such as sauna should be too (not yet reached sauna owners club).
It’s like who keeps on GLP-1/GIP agonist lifelong low-dose for the metabolic benefit it does bring, not just for a session of weight loss.
So in that sense i perceive and plan to get into HBOT as a practice, how often?
I don’t know yet, but a close friend of mine who’s wife run an hospital hbot center, do at least once weekly since ever and report to be highly appreciating subjectively the benefits.
Fabio
Ulf
#64
I appreciate you took the time to make this detailed response on the claims for telomere strengthening. What a pity that after all efforts tests were not done several months later.
It reminds me of Therepeutic Plasma Exchange showing good short-term results but little long-term. It seems that non-continuous Interventions in principle should include testing at least six months later.
Some people will without doubt do that, like Bryan Johnsson, but I think using it regularly over years is too risky, not to mention too expensive for most people unless they have a chamber at home. I personally wouldn’t use HBOT regularly even if I could do it for free. I think the risk of harm is too great.
Appreciate and is required to assess all safety related risks, not just to malfunction of the chamber, but to health itself.
Asking gpt-5 for it revealed the following based on long-term treatment with hbot at 2.0 ata with 100 oxygen:
| Risk Type |
Details |
| Pulmonary Toxicity |
Lung inflammation, chest pain, shortness of breath |
| CNS Toxicity |
Seizures (rare), cognitive disruption via ROS and pressure effects |
| Ocular Problems |
Temporary myopia; potential increased cataract risk |
| Barotrauma |
Ear/sinus pain, eardrum rupture, rare lung collapse |
| Dental/Implant Effects |
Implant instability with repeated exposure |
| Oxidative Stress |
Chronic ROS generation, cell damage if antioxidant defenses overwhelm |
It will be interesting to get deeper on research about the long term uses (based also on different frequency and duration of treatments), I’d particularly consider too the effect of angiogenesis and telomere extension (positive on one side, but possibly also oncogenetic).
Fabio
1 Like
When I am living in Birmingham I do daily normobaric hyperoxia on an oxygen concentrator for about 8 mins one session.
Matze
#69
Which effects do you have doing that?
In that video this was the first time his apperance dident look “weird” and “off” (as he is vegan) but he truly looked rejuvinated post all those HBOT sessions
It also seem to have cured his brain injury from the childhood vaccinations. He had the chris bumstead speach thing going on but it seems almost gone now = brain rejuvination
He would prob need a heavy metal detox as well to get all that mercery n alumium out of his brain. but seems like HBOT cured the symtoms, still need to get rid of the cause (metals)
Its difficult to isolate out the effects of individual interventions. According to my reading of the literature it should stimulate HIF 1 alpha.
