That’s great to hear! That takes away the doubt.
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Rapamycin should have a slow effect. However it should last
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I agree. I’m always suspicious of things that cause a noticeable effect on skin in a matter of just a few weeks. I think noticeable rejuvenation would take longer than that, specially considering the turnover rate of skin cells. Things that have a quicker effect often just increased hydration of the skin, which can make it look better almost immediately.
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Beth
#1274
*raises hand
@John_Hemming and everyone
I would have thought that if you take rapamycin orally, then it’s getting into your skin.
Having said that, there are so many smart people here who mix rapa powder into lotions that I assume it could have additional skin benefits if we also apply it topically.
My wonder is do we then need to worry about getting too much rapa into our systems because we absorb what is on our skin? This question is especially important because if we think it will help our skin, I could see mixing it into body lotion.
Any thoughts on this topic would be appreciated
The advantage of topical rapa is that you get more into your skin and less in the rest of the body. Hence the side effects from high levels are not so much of an issue.
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I second what John said. It gets into the skin when taken orally but it can get into it at much greater concentrations when used topically. Also topical use does not carry the risk of interfering with blood glucose or blood lipids because systemic absorption is too low when using it on the skin.
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sol
#1277
My experience tells me that you’re lucky if topical rapa gets into your skin at all, never mind getting into your system or deeper tissues. Or you have some carrier stronger than transcultol, which can carry its own risks. Or you’re using a mechanical assist, like microneedling.
Recall that skin is really good at keeping things out – that is its primary job, after all: keep the insides in, and the outside out. Skin is highly optimized as a barrier and rapamycin’s molecular weight does not make it magically sink into your skin, the way some hormones can.
I’ve been using topical rapa with transcutol for now nearly 2 years, and (subjectively) haven’t seen any changes. (Am now trying micro needle rollers to see if I can, heh, move the needle and get the serum deeper. Will report back if I see any improvements.)
Oral mucosa is a different story – that mucosa might well take in rapamycin more easily, and I’ve heard strong annectdotal evidence on our forum that it does. So, I use rapa daily in my teeth-brushing routine.
To your question, @Beth, my subjective experience is that even my teeth brushing mucosa applied rapa use isn’t affecting me systemically. I’m very sensitive to rapamycin when I take it orally – can easily tell I’ve taken it, with lots of quite clear effects – and I don’t feel any of that from topical – or even oral – application of my rapa serum.
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DMSO can I think carry it.
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Well the effect is good. I want to compare to other people’s results. Seems like a promising skincare ingredient.
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Yes, hopefully some other people that have access to it will try and report back. I haven’t looked into this chemical, but given that it would be used topially rather than orally the risk sholuld be very low.
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Lots of people buying and consuming it.
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blsm
#1282
I hope this question isn’t breaking any rules (if so my apologies and please delete). Does anyone have a reputable source for injectable skin products?
Hi there LaraPro - is that the one called d’Alba Piedmont - cream and serum? That is what comes up first when I put in your title - but there were 14 possible choices. Thank you for helping me to sort this one out.
Hi Tim - here at the Orthopaedic Pain Clinic, I have been receiving Synvisc injections - the doctor uses imaging to be able to pinpoint the area to give me effective relief. The problem there is deteriorating cartilage. These injections are much more helpful than steroid shots, and better for the joint. I understand there is a German company making progress with cartilage replacement - they are hoping no more knee replacements - me too, after having to revise the first right knee replacement, which failed.
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This does not break rules, people ask for sources for stuff all the time.
I have no idea about this particular request though.
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blsm
#1287
Thanks, I appreciate your response. I’m specifically looking for profhilo if anyone knows of a good source.
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This is fascinating, and has a crossover connection with discussions about DNA mutations:
https://www.nature.com/articles/s41588-023-01468-x
Here we show that, compared to Singapore, aging facial skin from populations in the UK has a fourfold greater mutational burden, a predominant UV mutational signature, increased copy number aberrations and increased mutant TP53 selection.
There are very large differences in skin DNA mutation rates between people in Singapore and people in the UK, and yet Singapore gets a lot more UV light! (Worth pointing out: these mutations may affect vitamin D synthesis, which could make the problem even worse.)
It makes one wonder what other differences there are between populations regarding DNA mutations. It also should make one wonder just how important DNA mutations are to aging – if you have a population with dramatically larger DNA mutation rates than another, yet this population has very similar lifespan to the other, then it would suggest DNA mutations aren’t as important to determining lifespan as expected.
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LaraPo
#1289
I ordered from this site, it’s not the best price but they accept payment through Amazon account and deliver fast.
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blsm
#1290
Thank you so much, I greatly appreciate it!
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It is a prescription only medication so this isn’t an indictment that he is just trying to scam money. He also says you can just get the prescription elsewhere.
There might be minimal systemic effects but it is generally accepted in the TRT space that you need specially formulated free base testosterone for it to go systemic effectively.
Additionally in one of his latest videos on the subject he stated he starts people on a 1% concentration. A 1% concentration of an esterified testosterone shouldn’t really have much of a systemic effect.
He addresses this. If you get acne you should probably just stop. I’m almost certain you’re not going to get acne at such pitifully low doses with pitifully low systemic absorption.
Some people react negatively to retinoids as well.
Overall I think this is something worth researching further and I’d love to see men and women here try it out. I’m thinking of trying it. I’m already on TRT so I don’t even care about systemic effects.