#956

Am I correct in assuming that meso therapy like the Cytocare is beneficial for superficial skin rejuvenation and for a deeper rejuvenation / maintaining face volume over time, Sculptra is a good product? Or to you recommend something else?

#957

You and your friend are an exception to some extent. I know a few 60y/o with great skin but the sag is starting and will continue.

I just turned 69 and I can see the difference in just the past 2 years. And I do a fair bit for my skin.

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#958

CytoCare is only for superficial skin rejuvenation and hydration. Itā€™s for very fine superficial lines. It doesnā€™t change volume or shape. Sculptra is a very thick filler that promotes collagen. Itā€™s for serious volume or changing shape, like jaw line. I donā€™t have personal experience with Sculptra. I know that it should be done by a professional because if you make a mistake and apply too much itā€™s impossible to correct it. Itā€™s easier to work with Juvederm line fillers. I tried almost all of them and they work great. You just need to know which to choose depending on what you want to do. Letā€™s say Voluma works great for volume.

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#959

Are you taking Rapamycin? If so, at 60 you are supposed to feel like at 50 :grinning: and itā€™s too early imo to have sagging skin at 50 unless there are serious health issues. All aging clocks I use show that Iā€™m around 46-50. Thatā€™s why I donā€™t have sagging skin. Itā€™s too early for me.

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#960

Just like tooth growthā€¦ until a researcher in Japan found a drug deactivates a protein called USAG-1 that inhibits tooth growth.

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#961

https://www.rejuvenationolympics.com/dunedin-pace

Look up Joan Matheson 67y/o (in the top 50) and Stephen Matheson 69y/o (in the top 200) out of over 3700 participants.

Been doing these tests for 4 years, 5 tests.

Yes we both do Rapa - 6mg with GFJ every 2 weeks

My most recent blood work is super duper :slight_smile: best itā€™s been in 15 years.

BUT that doesnā€™t negate the fact that elastin has a 70 year half-life and that all humans stop making it just after puberty. This means the half-life number kicks in at about 80 years old.

#962

I can live without teeth but I canā€™t live without elastinā€¦

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#963

My point is that you may not have to, the pace of research is crazy
I couldnā€™t even imagine that one could reactive tooth growth few years ago
Something stops the elastin productionā€¦ but it doesnā€™t mean that the stop cannot be reversed.
Itā€™s all encoded in DNA, just have to copy to mRNA and transcribe it.

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#964

Do humans definitively stop producing it at puberty or does it just slow to a crawl? Iā€™m admittedly no expert but I seem to have run across conflicting information.

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#965

When you really think about it, within the past 30 years we managed to regrow hair and teeth, something humanity has been yearning for since its beginning.

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#966

Smooth muscle cells, fibroblasts and endothelial cells probably keep producing it at a slow rate.

In a stable state, the basal levels of elastin expression and breakdown remain low in adult tissues and cells isolated from adult tissues. In vivo , elastogenic cells including smooth muscle cells, fibroblasts, and endothelial cells can produce and secrete tropoelastin, moreover, we found that the co-expression of cardiac troponin T and elastin were detected in rat cardiomyocytes and rat myocardial tissues. Thus we speculate that the rat cardiomyocytes can secrete elastin and it may be involved in the potential energy of myocardial cells and the construction of intercellular elastic fibers.

Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases - PMC

So there must be a pathway to upregulate this process somehow.

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#967

What would you use for laugh lines, if you had them? Would you do it yourself?

ā€™

#968

With such a long life, even a little regeneration would go a long way.

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#969

I would and I did it myself many times, but donā€™t advise that you or anybody else does it without proper training. There are veins under the lines that are easy to puncture or, even worse, inject filler into the veins. You need to know anatomy well to do that part of the face. Are you trying to do it yourself? :scream:

#970

No, I was just asking, and you clearly answered my question. I wonā€™t try it. Thanks.

#971

Per this article, Radiesse restores elastin. Donā€™t know how reliable this info is, but itā€™s interesting.

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#972

possible increase in elastin

Evaluating the Effects of Injected Calcium Hydroxylapatite on Changes in Human Skin Elastin and Proteoglycan Formation

Noelani GonzƔlez 1, David J Goldberg 1 2

Affiliations Expand

Abstract

Background: Previous studies have shown that calcium hydroxylapatite (CaHa) injected intradermally resulted in new collagen production at 6 months after injection, and a possible increase in elastin formation. In addition, a recent study showed the formation of new collagen, elastin, and angiogenesis after injection at 4 and 9 months.

Objective: To evaluate any changes in the presence of elastic fibers, proteoglycans, and elastin in photodamaged skin after injections with CaHa.

Methods and materials: Fifteen subjects underwent a punch biopsy of the right infra-auricular areas before and after injection of CaHa on day 180. Specimens were stained for elastic fibers, elastin, and proteoglycan presence.

Results: Quantitative analysis demonstrated a percent change in elastic fibers varying between 29% and 179% at 6 months in comparison with baseline. Subjects showed an increase in elastin between 12% and 66%. Subjects had positive mean percentage change in proteoglycans of 76.27% (t-test of 0.198).

Conclusion: This is the first study to show that CaHa can increase proteoglycans and echoed previous studies showing it can also have an effect on elastin, which indicates it can induce remodeling of all aspects of the extracellular matrix. Much larger and longer studies are required to confirm its unique impact on collagen, elastin, and proteoglycans.

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#973

Good news! It could be an explanation why my face did not ā€œdropā€ to create jowls as it often happens in ppl of my age. I use Radiesse on my jaw line approx once every 3-4 years. It apparently created a structure and support. I tried it once on my hands and it was very painful for approximately 24 hours, though the result was great. Wondering if Calcium Hydroxylapatite particles increase the total calcium to contribute to calcium deposits in arteries. I mean, is it safe?

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#974

What is the purpose of using it on the jawline? Is it meant to change the bony contour, or is it meant to stimulate ECM remodeling?

#975

Yes, with filler, some do it to create a sharper jawline, or to alter the shape a bit.

1 Like