#855

What did you think of this skin cream?

#856

I used it for 10 days only - twice a day. The results are wonderful so far. Some sun spots faded much. One is now hardly visible. Will definitely continue with it. The way I apply it though may be different from what most ppl would do. I use a triple nano needle to make very small holes on the spots I want to treat, and then I apply the enzyme. A micro needling roller can also be used. There are no instructions that come with this product.

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#857

Itā€™s not a cream but rather a serum.

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#858

How old are your spots? Iā€™m thinking of maybe giving it a go, with some decade long spots that Iā€™m curious if I can resolve. never done micro-needling but willing to give it a shot

#859

My spots are not old, may be year or so.

#860

Our previous studies have shown that the topical application of HAFi reversed skin atrophy in dermatoporosis patients by a CD44-dependent mechanism [7]. CD44 is the main cell-surface receptor for HA and is present on a membrane platform called hyalurosome along with other molecules involved in the metabolism of HA and cell signaling such as heparin-binding epidermal growth factor (HB-EGF), HB-EGF receptor ErbB1 and hyaluronate synthase-3 (HAS3), located in keratinocyte filopodia [6]. Specific suppression of CD44 in keratinocytes leads to skin atrophy in transgenic mice, suggesting that CD44 plays an important role in the regulation of epidermal homeostasis [8]. We have also demonstrated that RAL and HAFi show a synergistic effect on skin hyperplasia in mouse and human skin and seem to have a therapeutic effect in dermatoporosis [6]. Furthermore, our studies indicated that the topical RAL and HAFi combination regulates the expression of hyalurosome platform genes and shows a dose-dependent effect on the reversal of skin atrophy in dermatoporosis patients [9].

The senescence of skin cells is an important feature of skin aging; however, we have demonstrated the advanced stage of skin aging by the increased p16Ink4a immunostaining of epidermal cells for the first time in dermatoporosis patients. Therefore, the clinical improvement observed by the application of the RAL and HAFi combination raised the possibility of elimination of the senescent cells residing in the epidermis.

The fact that the clearance of p16Ink4a-expressing cells in BubR1-hypomorphic progeroid mice delays aging-associated disorders and the results of other studies suggested that elimination or weakening of the function of senescent cells may be a promising approach for age-related pathologies. These strategies are collectively named ā€˜senotherapiesā€™ [10]. There are two kinds of senotherapeutics: senolytics, which induce senolysis in senescent cells, and senomorphics, which attenuate their pathological proinflammatory secretory phenotype to cause senostasis [11]. Each senotherapeutic modality has various advantages and disadvantages. Many senolytic agents including synthetic small molecules and peptides have been developed for in vitro and in vivo [12].

Recent clinical trials conducted with senolytic agents in age-related human disease showed significant clinical improvement. In the first clinical trial of senolytic agents, Dasatinib and Quercetin decreased physical dysfunction in patients with idiopathic pulmonary fibrosis, a senescence-associated disease [13]. In another clinical trial, Dasatinib administration to patients with systemic sclerosis reduced the SASP and other senescence markers in skin biopsies [14]. Dasatinib and Quercetin, used in another clinical trial, significantly decreased senescent cells in patients with diabetic kidney disease [15]. There are currently other ongoing or planned senotherapeutic clinical trials [16].

Dermatopathology | Free Full-Text | Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis

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#861

Update: Have been using it twice a day (morning and night) for almost 1 month. Novos facial aging app detected a 10 year facial aging improvement, from 46 before to 35 now, 3 years of eye aging improving from 46 before to 43 now. Will definitely continue using.

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#862

Can you link to it? It might be a good gift for my wife.

#863

Itā€™s on Amazon BACHERI Ergothioneine Firmingā€¦ Amazon.com

5 Likes
#864

How many are in each box? Interestingly, they donā€™t say.

#865

I didnā€™t count when I started, but I think 30. They also donā€™t provide any instructions. I use one vial for 3 applications (morning, night, morning).

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#866

Hello, How are you finding this after a few more months? And which product specifically is it/strength?

#867

Hello,
Iā€™m going to continue using it for the improvements Iā€™ve noticed with the tendency towards dry/tight feeling facial skin with menopause. I havenā€™t noticed any miraculous changes in my appearance although in the first week I felt I looked brighter/fresher which could have been placebo? I figure if my skin feels better hydrated then that alone could possibly help over the long term.
This is the cream I used simply because itā€™s what I had on hand from In house chemist-

Itā€™s possible there may be better pricing available elsewhere. I have used another estriol cream in the past called Evalon from All Day Chemist which worked equally well vaginally but as of today itā€™s currently out of stock.

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#868

Iā€™ve never tried HRT bc Iā€™ve never experienced any symptoms connected with menopause. Never had a hot flash or dry skin, etc. and I donā€™t know why. My mother had hot flashed that bothered her for years. I think I had none because of rapamycin that I started at 54, but Iā€™m not sure about that. Wondering if I should also try an HRT cream on my face. On the other hand, I donā€™t have dry skin. Will it help with anything else besides dry skin?

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#869

Youā€™re probably right about rapamycin helping you have a smooth menopause transition. I thought Iā€™d read somewhere about estrogen possibly helping with collagen levels but Iā€™m not sure if itā€™s been proven or not. I read anecdotal reports from other women claiming it helped their skin appearance so I figured Iā€™d try it out. If I can find anything In the scientific literature Iā€™ll share.

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#870

New Ultherapy method: Utilizing novel surgical and anatomical concepts yields outstanding results

Results: Statistically significant differences in lifting effects and improvement in skin laxity were observed between the two groups. The new method, with a focus on the parotideal area of the SMAS, demonstrated superior outcomes and higher patient satisfaction.

Conclusion: The parotideal regionā€™s accessibility, increased thickness, and safety profile make it an ideal target for Ultherapy. This not only reduces the risk of nerve injury but also yields effective collagen remodeling and skin-lifting results.

Full, open access paper: https://onlinelibrary.wiley.com/doi/10.1111/jocd.16374

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#871

Thanks. I have the Ovestin and have started today. Blessed to be Australian. $15 per tube. I will try and see if I can get a prescription for the ,3% compounding variety in a few months after trialling this. .

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#872

This is really impressive, and it doesnā€™t look as if there is any need for new technology. I wonder how long it will take for this to trickle down to regular clinics.

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#873

@LaraPo, hereā€™s one write up on topical estrogens impact on skin. Iā€™m not a scientist so Iā€™m more than open to feedback on the quality of the information presented.

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#874

Has anyone posted about a moisturizer that includes hyaluronic acid? The options in the UK cost Ā£30 plus, and the ones from India have many unfamiliar ingredients but are much cheaper. Can anyone recommend a product? Iā€™m trying to address dry skin resulting from three applications of adapalene and some unintentional sun exposure through my window. It might also be from the red light therapy sessions Iā€™ve been doing, but Iā€™m still figuring that out. Iā€™ve read that some people need to moisturize, and I think adding a topical hyaluronic acid could help. Hereā€™s one product I was considering:

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