Paper:

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I have been supplementing with nitrous oxide.

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NO (a gas) is more complicated than taking a vitamin supplement. You can supplement arginine or citrulline (to make arginine) but older bodies can’t use the arginine as well as younger bodies (50-70% loss of function) to make NO. You can supplement nitrates but if you have killed your oral microbiome with antiseptic mouthwash you won’t get the nitrites needed to make NO. Plus, it is safer to get the nitrates with vitamin C (as you do in plants) to eliminate the risk of making carcinogens. Check out this Texas A&M video for details.

Functional Nitric Oxide Nutrition

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I honestly think cardiovascular disease is a solved problem at this point. It’s mostly about keeping lipids low & for a long time.

I only have question marks about diet and cancer, for example. That would be interesting to me.

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Good to know that you have solved it :sweat_smile:

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I think Atherosclerosis is caused by a failure of cells to differentiate properly.

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Well there is no case of atherosclerosis if lipids are low.

I like Dr. Avi Bitterman’s challenge:

"Open challenge for those who don’t think LDL is a necessary condition for atherosclerosis:

Find me one single patient with total Abetalipoproteinemia (entails LDL=0) who has ever:

-Had an MI secondary to lipid plaque rupture.

Or

-Had lipid plaque build up in arterial wall"

https://nitter.net/AviBittMD/status/1662161326234271748#m

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I am not saying lipids are unimportant.

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Sure, if you have kept lipids low your entire life and you haven’t been disfavored with any poor genetics, then this should not be an issue for you. But if no, it’s a stark illustration of why no one can never read some studies and hope to provide any advice that is even slightly cogent without practicing in the field for 20 to 30 years.

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Again, you’re free to show a case of total abetalipoproteinemia (ā€œwith poor geneticsā€) that have developed atherosclerosis or MI from plaque rupture… Lipids are a necessary condition, until you realize the magnitude of this, you will still argue for example which sort of tea is correlated with lower rates of cardiovascular disease.

I also am speaking generally and not specific to any situation, obviously. If someone already has atherosclerosis, that’s different…

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Yes, I was reacting more to what sometimes seems like unwarranted hubris on your part. I admire your passion, but you really can’t speak knowledgeably on an area that you haven’t been trained in and don’t practice in. But part of the fun of this site is that we all get to do that here since we are all experimenting together.

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https://twitter.com/DrDaleBredesen/status/1682452886633201664?s=20

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Unfortunately I can’t access the study, but reading about KetoFLEX 12/3 I was shocked to realize that plant based does not equal vegan. I always had in mind plant based diet is vegan.

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Ketoflex describes itself as ā€œheavily plant basedā€ rather than 100% plant based. So I think you are still correct in your assumption that plant based means vegan.

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I researched it further and came upon this definition:

Plant-based or plant-forward eating patterns focus on foods primarily from plants. This includes not only fruits and vegetables, but also nuts, seeds, oils, whole grains, legumes, and beans. It doesn’t mean that you are vegetarian or vegan and never eat meat or dairy. Rather, you are proportionately choosing more of your foods from plant sources.

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I have to say I think that particular Harvard definition is a bit of a wishy-washy cop out personally. I think it would be far more accurate for people who occasionally eat some meat or other animal products to be referred to as largely or mostly plant based. I used to describe my diet as ā€œmostly veganā€ before I cut out honey for example. Also, as to what then is the difference between plant based and vegan? I would say that plant based refers only to one’s diet whereas for vegans their choices go beyond just what they ingest, for example not wearing leather and avoiding animal derivatives in toiletries, etc.

Having said all that, clearly what we choose to eat is very much a personal decision and I would always advocate that we all need to make our own choices and that no one way is necessarily better than any other. Although I have chosen to be a vegan myself I would never seek to impose my views or ethics on anyone else and I would also fight for other’s freedom to live the way they choose. Live and let live.

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I would like to have the power to become vegan , I think being vegan is the most ethical decision you can make about eating food. But as much as I try to reduce animal products I cant’t seem to do without eggs, butter and cheese. I hear there is a complete new cheesemaking movement in vegan cheeses and that they are really becoming good but eggs and butter I don’t think I could be without. The goal for 2024 is to try and reduce starches and starchy vegetables and try something like Harvard definition or mostly plant based diet. I don’t like totalitarian diets or diets where there are too many rules. I eat cause it makes me happy and I enjoy food and ATM I really enjoy my (really) occasional croissant, cake slice or steak, fish or roast chicken.

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If you enjoy all those foods it would be very difficult for you to switch to vegan. I never enjoyed steak or chicken, so it was easy and natural to become a vegetarian.

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I’ve had steak and chicken that were not so good, but if you get the kind with lots of fat? Holy crap. I was watching a show on PBS years ago (about life in the arctic I think) and a whale had died and a polar bear came upon it and started eating the fat and she just went crazy. Rolling in the fat and stretching and eating and just having some kind of one bear food orgy.

I like it maybe not quite that much, but if you make cheese without fat, or steak without fat or chicken with no skin; I can see why you might want to go vegan. Not so good without fat.

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Absolutely true - life is for living! Whatever you enjoy you should do. At the end of the day there is no point striving for longevity if we then don’t enjoy the life we consequently lead. Everything in life is a balance. I think it’s great that you are striving to reduce your animal intake - so long as you remain happy and enjoy life.

For me, much as I enjoyed the taste of a steak I couldn’t live with myself knowing that I had been responsible for the taking of that animal’s life. But obviously that is just me, and we will all have our own personal perspectives on the subject. Perhaps if I had been raised on a farm where I had got used to seeing animals slaughtered from a young age I would have come to a different conclusion - or maybe I would have just become vegan even younger, lol.

On the vegan cheese front, there are always new innovations happening. Some taste great to me, others not so much. My personal favourite at the moment is the blue cheese from honestlytasty.co.uk which is a small UK based manufacturer. Unfortunately they don’t ship internationally which is a shame as I think their products would go down a storm in the USA and the rest of Europe.

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