#150

These are the only references I found on an internet scrape:

“I also think, you know, it’s unfortunate, but a lot of scientists do what’s easy. And, because of the reputation problems, there’s more work involved in getting a clinical trial going with rapamycin and getting it through the IRB. There’s also a little bit of shiny new object syndrome in this field. And I think people have known rapamycin works really well in preclinical studies and haven’t paid as much attention as they probably should have. And then of course, rapamycin is off patent, and it’s been off patent for many years. And so there hasn’t been a lot of incentive for companies to move forward with clinical trials for rapamycin for other indications. That, I think, is being helped by newer versions of rapamycin. For example, there’s a company called Trivium Vet, that has a version of rapamycin that’s enteric coated for better release in the intestine. There are some other potentially more mTORC1 specific inhibitors that are rapalogs that are being developed. And then of course, the catalytic inhibitors that I talked about.”
https://mkaeberlein.com/rapamycin-is-the-gold-standard-for-longevity-interventions/

From 2021:
“The drug will be given once a week based on the human data from clinical trials with everolimus, which is a rapamycin derivative. It seems that an equivalent total dose given once a week rather than daily has better efficacy with reduced side effects. We are using a form of rapamycin that is coated for enteric release. It’s not the eRapa (encapsulated rapamycin) that’s used in mice, that’s a different formulation, but it is also not exactly the same as generic rapamycin (sirolimus) tablets that organ transplant patients take.”

1 Like
#151

Started my 5kg 8.5-9.5 y.o. mixed breed in the beginning of February. Using Rapacan to start. Splitting the 1 mg pills in quarters, putting into a cheese coated enteric coated capsule and dosing with a higher fat meal. The plan was to titrate up towards the high end of the previous DAP study dose (.15mg/kg) and wasn’t sure if I’d give once weekly or divide it up into 3x’s/week based upon Matt K’s worry about the dose being a little low, very few to almost statistically absent adverse effects from the previous trial and thinking once per week was really to enhance compliance from dog owners. We started at .25mg once per week and we’re up to .25mg twice per week. This thread and others on this forum have been invaluable in helping us figure out sourcing and dosing. Very grateful for that :pray:. Many thanks to everyone here.

He is definitely friskier, drivier, and has increased intensity and stamina. This has enhanced all of his great characteristics and some of his less attractive traits like resource guarding and separation anxiety. Overall realizing more energy in both directions. Perhaps what we saw as maturity and mellowing was aging and less energy :woman_shrugging:t2:. We could usually kick back after dinner and watch the news or a movie, but he now demands more stimulation (and food), so we have added more training and brain games in the evening.

He’s developed a sore on his belly unlike any he’s ever had. He doesn’t get hot spots and the rest of his belly isn’t red and irritated. I wonder if this might be from the rapamycin, maybe his version of the canker sores humans often get on rapamycin. We’re going away for a week and I think it might be a good time to take a week’s hiatus. And now, we may not be titrating any further at this time.

3 Likes
#152

Great post, thanks for sharing.

I suspect the red sore is associated with the rapamycin use. Temporary skin rashes and sores are pretty common with rapamycin. Take a break and I bet it goes away.

3 Likes
#153

We see all of this wonderful data on Rapamycin in mice and dogs. It just confirms for me that Rapamycin is helping humans as well. Thanks for sharing your stories!

2 Likes
#154

Is anyone not using pill form rapamycin for their dog? I have rapamycin powder I’d like to start giving my dog (~70lb rough collie 3.5 years old), but I’m not sure about the best way to administer it.

Also, mine was purchased from a US chemical supplier and I the purity was quoted as 98%+. Can anyone recommend a quantitative testing service that isn’t prohibitively expensive?

#155

I think you’ll find it not worth the hassle to do what you’re trying to do. I would just use the rapamycin powder for Rapamycin toothpaste, or rapamycin skin cream, and buy regular tablets for your dog.

You can buy rapamycin tablets from India for about $1.20 or less per 1mg tablet, that you know will work. To make your own… and to do blood tests on your dog (I don’t think blood sirolimus levels for dogs are even available) is hard, and expensive, and if you can’t do the blood tests you don’t know if the rapamycin is even getting into the blood.

Its hard due to the fact that rapamycin typically gets destroyed in the stomach acid, if it doesn’t have good protection.

I recommend you review these posts. And perhaps anyone who has been successful in this effort can add their thoughts…

here: Rapamycin enteric coating vs powder bioavailability

here: How many are making their own solutions from powder?

here: New Peter Attia interview w/Matt Kaeberlein, inferior bioavailability of encapsulated rapa

related Sirolimus Powder - 3rd party analysis

4 Likes
#156

Do you think the belly sore was an indication we needed a slower ramp on titrating? Can you share the ramping protocol you used for your pup? I remember you saying it was slow. TIA

#157

Its a little more difficult to “ramp” when you have a small dog. My dog weighs 24 lbs. And you can’t split sirolimus tablets. So I started with 1mg, and perhaps 2 months later went up to 2mg. I generally try to do my dog on the same schedule I’m on so its easy to remember.

2 Likes
#158

Thank you @RapAdmin. I guess I’ll just use it to make my own topical, and perhaps make some toothpaste also.

I need to look into ordering some from overseas. The last time I checked the prices they actually weren’t much cheaper than my Healthspan subscription. But if I’m going to be ordering for my dog, and I’d also like to order some for friends and family members, I’m going to have to shop around a bit.

#159

Talks from WVC 2024- Nutrition for Lifespan Extension and Frailty

Source: Talks from WVC 2024- Nutrition for Lifespan Extension and Frailty |

#160

Hello everyone,
I am new to the group but I have been reading the posts and found a lot of useful information. My 7 year old Standard Poodle just started taking rapamycin 10 days ago for overall health preventative purpose. I am ordering the capsules from Dr. Kevin Toman. But I was just informed that the compounding pharmacy he has been using is retiring/closing so he will switch to generic rapamycin tabs and the cost for 3 mg doses will be higher since he has to combine 1mg and 2 mg tabs.
So reading about reputable pharmacies in India on here, I ordered some Zydus 1mg tabs. I trust Zydus since their brand is FDA approved. The cost is much less compared to getting it from Dr. Toman, even Zydus brand is the most expensive one out of all the generic offered from India.
Our dog is getting 3 mg three times a week dosage and so far doing well.
Hope to share and learn more about rapamycin’s use in dogs.

2 Likes
#161

Welcome to the forums. Please post periodically on how your dog is doing and update us. Are there any specific issues of age that your dog is suffering from yet? Have you seen any change in the dog’s energy level or playfulness or any other metric (good or bad)?

#162

Thank you for the welcome. I will post updates. :slight_smile: No specific issues we are trying to address but the data we have so far really make sense to me that rapamycin can help improve health span, not just life span. So far, I haven’t notice any changes but it has only been one week and half since he started. I am sad to learn that the current DAP study doesn’t have enough funding to continue…so I didn’t want to wait any longer before starting our dog on it.

3 Likes
#163

I personally would prefer Zydus, even Biocon, over a domestic compounding pharmacy.

3 Likes
#164

Yes - its something to be careful of. We’ve seen issues with some compounding pharmacy products, so its a good thing to check their testing of their product (ask to see what they’ve done to validate the bioavailability issues - rapamycin, if not well protected, will get destroyed in the stomach otherwise).

And yes, Zydus and Biocon are well proven and the companies are large and sell FDA approved products so I trust them more than the typical small compounding pharmacy that may not know about the bioavailability issue of their products.

See these threads:

3 Likes
#165

I am happy to be switching to Zydus brand products- all thanks to the information shared here!

3 Likes
#166

Received the Zydus brand 1 mg tabs. Started my dog on them this week. He takes 3 mg three times a week with food. So far he has been on rapamycin for about 5 weeks. No negative side effects. As I mentioned there isn’t any specific health issues I am trying to address, just want to give rapamycin for general healthspan purposes.
I welcome other’s experience with giving their dogs rapamycin. Have a great weekend.

1 Like
#167

Wow - thats a pretty high dose for a dog (unless the dog is really big). in the new rapamycin dog trial called TRIAD at the University of Washington , they are dosing dogs once weekly, at approx. 0.15mg/kg of rapamycin.

1 Like
#168

My dog weighs 60 lbs. Dr. Toman recommends this dosage based on the first trial. He said the once a week dose is/was used for convenience, not because the three times a week dose is too high.
I read others using the three times a week dosage here as well.
Guess the ideal dosage is not known at this time.
Is the once a week dose better? How long does rapamycin stay in the dog’s system? Just giving it once a week seem to leave the system without this medication most of the time??

2 Likes
#169

OK. I’m not criticizing you, just making sure you know what has been done in the testing of rapamycin in dogs so far.

In the initial clinical study that the University of Washington did on rapamycin use in dogs, they used a dosing regimen as follows:

Dosing Schedule and Amount:

Schedule: Monday/Wed/Friday

  • The low rapamycin group received 0.05 mg/kg rapamycin (sirolimus) at each dosing.
  • The high rapamycin group received 0.1 mg/kg rapamycin at each dosing.
  • The dogs in the rapamycin treatment groups were dosed to the nearest 0.5 mg based on their body weight at the initial exam.

So, for a 60lb dog, (27.2kg) the low dose rapamycin (3 times per week) would be: 1.36 mg
So, for a 60lb dog, (27.2kg) the High dose rapamycin (3 times per week) would be: 2.72 mg

Actually, now that I’ve done the calculations, I see you are just at the high dose rapamycin. No issues - it just seemed a little potentially high given what little information I had. You’re just following the higher dose protocol which sounds like its working well for you and your dog.

2 Likes