#21

According to the study, IGF-1 remained unchanged?

#22

My levels increased from 260 to 360, I never had these kind of levels, so I will retest. My estradiol was increased 20% from HCG 500 IE weekly I added to my TRT. For the rest, I didn’t change anything in my routine.

2 Likes
#23

I got the idea that “higher dose” melatonin supplementation causes higher IGF1 from the Youtube performance coach Vigorous Steve . This is the only study I could find who could explain the mechanism behind it.

1 Like
#24

20% higher estradiol would more than likely raise IGF1 level, so that’s the likely explanation. What was your exact estradiol level?

As far as I know, high IGF1 appears to be worse if it’s naturally high with no explanation.

If you incorporate things that raise it, like HCG in this case, I don’t think it’s as much of a problem.

For instance, there has never been any causal link between HGH and cancer, despite HGH raising IGF1.

There are also no links to cancer for testosterone therapy, despite the fact it could drive IGF1 up a bit from the increased estradiol.

2 Likes
#25

Thanks for the reply, estradiol before was 39ng/l, it raised to 51. I am not worried about the high IGF1, but I want to determine the cause.

#26

I think that’s the probable cause. IGF1 was lower when estradiol was 39 and higher at 51, correct? That aligns with a lot of people’s experiences. When estradiol is higher, IGF1 is higher.

1 Like
#27

Correct. Since higher estradiol seems to be a good thing for longevity and i don’t have any negative symptoms, I will keep using the HCG as an add-on to TRT

1 Like