#6

Like most of the members here, Joan and I have been working on our health span and life span. As part of that we have both had 4 Dunedin Pace tests done as part of the complete www.trudiagnostic.com DNA methylation comprehensive test.

If you don’t measure it, you can’t manage it.

Joan is on the Leaderboard with a best Pace of 0.74 at position 16 for best Pace. Hundreds of bio-hackers have entered these Olympics and of those, Joan is in the top 20.

I’m rooting for her to get in the top 10 at her next test in September 2024.

Here is the site so you can check out who is ahead of her and who is behind. Many have spent 10’s of thousands, 1 has spent over $2M a year trying to slow, stop and even reverse aging.

https://www.rejuvenationolympics.com/dunedin-pace

Joan_Matheson_Rejuvenation_Olympics
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#7

Thx for sharing. I also see our @John_Hemming is #19 :slight_smile:
(I’m assuming it’s the same John!)

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#8

Most of the people ahead of Joan (age 67) are much younger. I wish they put the chronological age in there as well.

I know of a few of them, Simm Land, the top one is 28. Bryan Johnson (who spends $2M a year on his personal experiments and testing) is 46, Ben Greenfield is 47, Michael Lustgarten is around 53, etc.

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#9

Wait until you see her new SymphonyAGE results, they are startlingly good.

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#10

For vagus nerve stimulation, what device do you use?

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#11

The details are in the PDF.

I use a basic TENS unit and an ear clip, you can get both on Amazon for less at $100

I’ve tried several commercial units but so far none have worked as well nor do they provide the flexibility in settings that this unit/method does. I’ve been sorely disappointed in the commercial units.

The key is understanding the 5 parameters;

  • Mode – constant or modulated
  • Power – ma (milli-amps) or level of power, i.e. current
  • Pulse width – in μs (micro-seconds)
  • Frequency – in Hz (hertz or cycles per second)
  • Time – how long to run the device.

All explained in the PDF :slight_smile:

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Retatrutide - better than semaglutide b/c it goes after 3 targets AND reduces microplastic exposure
#12

Hey Steve, have you ever tried the Nurosym? It’s the one Brian Johnson uses. I paid a small fortune for it and had it shipped from England. It seems to work, in the sense that I can feel the tingling and pulse in my ear tragus, but it doesn’t seem to do anything for my HRV. Am I supposed to see immediate increase in HRV during and after a session, or is it something that one done every day over a certain period, one sees gradual rise in HRV?

Oopps never mind! I read the PDF file. Wish I’d actually read more about this before now because I clearly gave up on this too soon. I’ll start doing my 20 minutes every night and report back!

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#13

I’ve tried several of the commercial vagus nerve stims and none perform any better that the DIY version and some I tried had no effect on my HRV at all.

For me the key is having control. Having control over the 5 parameters that make it work as opposed to some “program” with a bunch of pre-sets.

Having contrl allows me to experiment with timing, pulse width, etc as new research comes out I can try to duplicate the findings. 100hz was found to reduce BP, so I tried that and it did for me. Not a lot but over a 6 week period it was a consistently measurable improvement.

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#14

One of the great things about being a Trudiagnostic customer is that as they add new algo’s to their platform, you learn something new about your epigenetics.

This new one is the Mitotic Clock.

A study by Andrew Teschendorff, PhD found that inflammatory conditions also increased mitotic rates in tissue (Teschendorff 2020). Increased mitotic rates measured with this algorithm could also indicate stem cell depletion.

Attached is my Mitotic Clock report and it’s most excellent :slight_smile:

Steve-M_mitotic_clock.pdf (560.2 KB)

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#15

Here is another new report on… # Inflammation

Another new algo applied to my DNA data. CRP derived from DNAm may be a better measurement than hsCRP… This report explores the impacts of inflammation on biological age and accelerated biological aging by examining associated methylation patterns at various locations of your DNA.

My DNAm CRP is high and I have an idea why. It rose rapidly due to a covid infection Aug 2022 and one other thing I’ve been fighting.

My DNAm IL-6 is reasonably low.
Steve-M_Inflamation_.pdf (2.4 MB)

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#16

A problem I have with TruD’s approach is that they replace biomarkers which have a real meaning with approximations from methylation data. As far as I personally am concerned this is a total waste of time.

In the end I am concerned about how my body functions. That can be measured accurately with biomarkers.

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#17

Trud should come out with a methylated height marker.

‘Well, my height is 5’ 9", but my DNAmHeight is 37 feet.’ And some people would have a negative height.

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#18

But the following seems to imply that DNAmCRP isn’t affected by short term infections:

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#19

If only Covid was a short term infection… and my other issue has been 2 years. It’s not a “serious” thing but it is proving to be difficult to clear completely.

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#20

Thanks for this detailed document @Steve_Combi.

I have the NuroSym, but I haven’t used it much (shame on me: I’ve never measured my HRV… Just ordered the Polar H10). Do you have any thoughts on this device by any chance? (I had a regular TENS before, but it was recalled by the manufacturer due to a problem, so I chose to pay the high price for NuroSym…)

You’re doing 20 min/day in the evening. How long did it take to see improvements in HRV? About 2–3 months according to the chart page 16?

Did you see any positive or negative impacts of some drugs you tried? Semaglutide? Beta-blockers? etc.

#21

The improvement was slow but steady and was also “sticky” I could go a couple weeks without doing tVNS and my HRV stayed good.

I have not done tVNS for about a year and my HRV has dropped. So I don’t know if that is due to the stoppage of tVNS (which I think is the biggest factor) or the Tz and or the Rt.

I am going to start it back up tonight though, It’s been on my mind for a couple months.

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#22

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@Steve_Combi these charts just show your morning HRV, correct? So you wake up, stay in bed, put whatever device on, measure it, and then remove it and start your day and EliteHRV automatically plots that?

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#23

Yes, that is correct. After reading about what devices are accurate enough (most are not) and the proper time to measure HRV, I settled on EliteHRV and the Polar10 strap. I did purchase a device from EliteHRV that they no longer sell, it’s a finger clip and a bit more convenient for the HRV measurement.

The thing with HRV is in the “V”, variable is the key as our HRV changes with activity and can be very misleading. By doing it immediately after waking and not getting out of bed, either lying down or sitting up, you get a consistent and more reliable measurement for a trend over time.

Any other measurements outside this window are indeed “variable” :slight_smile:

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#24

I checked out the NuroSym, the price is a bit ridiculous but the ear clip looks interesting, I’d love to see the contact area.

Nurosym Regular price $1,045.18 CAD

Also I don’t see any way to control the “program” I do see an intensity control in the manual but not much else. This is why I like the DIY method with a $100 TENS unit and a $15 ear clip. I have complete control of the 5 important parameters;

  1. Mode – constant or modulated
  2. Power – ma (milliamps) or level of power
  3. Pulse width – in μs (micro-seconds)
  4. Frequency – in Hz (hertz or cycles per second
  5. Time – how long to run the device.
#25

Even lying in bed after waking is variable. Alcohol consumption has a big effect (today is a drinking day)

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