#52

I’d be interested in hearing people’s thoughts on using a GH secretagogue in lieu of rhGH.

For example, ibutamoren is much easier to administer (oral) and obtain.

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#53

I really think HGH gets a bad rap. I wish it would get studied more because there are definitely a lot of benefits. As long as you tackle the issue of increased insulin resistance from it (Acarbose, Empagliflozin, etc), I don’t see a downside if used at physiological dosages

#54

Not as good IMO. I hear benefits don’t last forever and you have to cycle (someone correct me if I’m wrong). I’d rather just use the real thing. And honestly, unless you jump through a million hoops to get an extremely expensive prescription for HGH, the precursors are really not much cheaper.

#55

medaura, You now have my interest. Where are those before and after pictures? If a real person like you has good results I’ll consider pursuing some type of treatment myself. However, I remain very skeptical that treatments of any type will be of any benefit to me.

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#56

DrFraser, The thing that has concerned me since reading about TRIIM is that once you stop the therapy the thymus will begin involution again, I assume. If this is the case how long will the results of the TRIIM or TRIIM-X trials last? Do you have any thoughts on this?

#57

Another issue…

While the first TRIIM study seems to have been somewhat successful, The Buck Institute has done a study on aging clocks and Eric Verdin has posited that the results that Greg Fahy announced with the first trial may be a false positive because of how the bioclock used measured things inaccurately. He said he contacted Greg Fahy to see if they could run his results with the new Buck Inst. clock, but didn’t get a response.

Eric covers the issue in this presentation:

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#58

We think new sets of T cells will continue to be active (as far of the effects of regeneration) probably for 8-10 years. We have no idea if doing the regimen 8 years from now will result in a second regeneration of the thymus and T cells.

This is the challenge – does one stop at 12-18 months, or continue on longer term? What are the risks of relatively physiological doses of HGH on longevity beyond this use for a year or so? Could the main benefit be a year of therapy, or could it be required to stay on it to achieve a sustained positive outcome - or could sustained use worsen outcomes?

The TRIIM trial and TRIIM-X are going to solidly fail to answer these questions. It leaves one with fascinating situation in this space of again not having sufficient data to be certain on what the situation is, and what the longer term role of this type of protocol is for longevity.

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#59

I am glad I listened to the video posted by @RapAdmin again.

I think TRIMM should really be open to scrutiny of their DNA results.

I have been thinking about what causes methylation of the DNA to occur. I am thinking there may be a relationship between failure of transcription and methylation. This would be something that would make the process of transcription (and potentially alternative splicings) to be a bit sticky.

Hence the distinction between epigenetic age of the different cells with some clocks, but not the clock that Eric Verdin refers to.

Hence it does appear that TRIMM was basically measuring something not relevant to the aging process.

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#60

My only thing with Greg was the fact that he looks real good/young for his age. Plus, he actually looks younger today than he looked 5-7 years ago. I can’t say that for any of the Dr/people in the antiaging field. So, I don’t know about aging clocks but whatever he is doing I’d love to do. The problem is he is elusive, because I don’t think he only does the TrIMX thing. He did mention he takes a lot of supplements but when pressed he only mentioned Carnosine. I’ve been taking carnosine for last couple weeks and I do like it a lot but can’t say what it will do long term. I intend to keep it in my stack.

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#61

He has obviously started taking care of his skin and hair in order to look younger because why would anyone trust a “longevity expert” who doesn’t look young (for their age)?

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#62

I suspect the unvarnished truth will be that the hgh + metformin+ DHEA + vit D / Zinc protocol does reverse thalmic involution but the price to pay is FASTER aging of most if not all tissues during the treatment time — that’s what Bryan Johnson reported of his personal results and that’s a side effect to reasonably expect from HGH. It’s a potent mTOR activator plus there are insulin implications.

I’d say that’s still a price worth paying for essentially resetting one’s immunity since the treatment is one and done after the original cycle and you wind up with a working thymus instead of a lobe of fat. Other interventions can then be used to hopefully reverse the damage on the other fronts. But yeah it would be nice to see all patient data.

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#63

Sure. Here’s the thread and pictures. More before and after pics of my lips through another intervention if you keep scrolling (spoiler alert, zero fillers :wink:). I’ve seen real people in skincare FB groups get real results from procedures which is what got me interested in trying. Other than surgery though, which I have no interest in, none of them do miracles in a single session or two. Consistency is key and for me both for budgetary and logistical reasons that means DIY. That takes discipline. It’s easy to press the trigger on a device then let it collect dust on the shelf. Yes certain stuff works but must be used diligently.

Scroll to the top. Somehow can’t link it from the top.

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#64

No, it is not just his skin and hair, his gait and his posture look better/younger now than I see him in some 5-7 years old videos. Plus, as I said, Noone in the longevity field (i.e. Attia, Sinclair and many others) and do mean no one looks younger than couple years their real age. When I first ran into him in one of his recent vid’s I said to myself he’s probably around 60 but looks good even for that age. When googled and found out he’s 73 I was really surprised. again, if someone preaches something they better look the part. don’t be like the Atkins diet doctor that said his diet is great for heart and then drops dead at 70 of a heart attack LOL.

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#65

He looks remarkably good for his age and naturally it makes me pay closer attention to what he’s got to say. Incidentally he’s how I heard of rapamycin. His study on thalmus rejuvenation made some noise or otherwise ended up on my feed and naturally what I did was look up dissenting views / skeptical takes. The first one that popped up was Peter Attia’s claiming the study was very poorly designed, that the clocks don’t even properly measure anything, and that the dosage had been tweaked for every patient making results so hard to replicate, that there was self selection bias from the participants being health nuts, and that metformin alone can probably account for at least some of the rejuvenation. Ended by saying something to the effect of, if we were to go by such thin evidence we should all be on rapamycin as it seems the #1 most promising anti-aging molecule. Looked THAT up, found Blagoskonny, and the rest is history.

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#66

Greg is enrolled himself in the TRIIM X trial. He was not enrolled in the TRIIM trial. He said he took HGH himself in 1995 but I do not know for how long.

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#67

Would it be fair to hypothesize that HGH is only pro aging if you can’t control the negative insulin sensitivity effects? I tend to think that as long as you can control glucose from worsening, it should be a net positive.

Just a theory though

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#68

No clue. From my layman reading there were plenty of other mechanisms in it that could independently be pro-aging. Bryan Johnson takes a boatload of supplements to control his blood sugar: metformin and Acarbose and a couple more if I recall, so if he can’t control those downstream effects, who can?

#69

My CGM readings in 2023 were materially better than 2022. I have posted the images. I dont take acarbose or metformin. I do take rapamycin and berberine, but i think the change is mainly a result of improved DNA transcription

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#70

I can. I take HGH and have no problem controlling A1C and fasted insulin.

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#71

Ok but do you have tests of your estimated biological age from before and after?