Glycine+NAC vs Rapamycin

[DeStrider]

Yes, you can test your glutathione levels. My father had his levels of GSH tested, and it is way above average even for a young individual. It also will beneficially impact your HBA1c and inflammation as seen by both my parents. Although it’s not huge, it is noticeable.

[Neo]

Nice. Thanks a bunch.

[DeStrider]

For me personally, I had a bit of OCD in that I would obsess over some of my interests. NAC has cleared that up for me. So, if you have any addiction, I thoroughly believe that NAC will help you break it. I also feel that it has improved my mood.

In addition, I used to have a lot of problems with bronchitis/asthma. Whenever I would get sick, I would have a hacking cough for 6 months afterward. It would get so bad, that I would cough up blood and develop headaches from all the coughing. It hasn’t happened since I started taking NAC over a year ago.

Overall, NAC has been a wonderful supplement for me and my own biology. I take 2.6 g daily along with selenium and molybdenum. Glycine has also been wonderful as well. When it’s time for bed, it just hits me like a brick and I fall asleep instantly. GlyNAC is a wonderful supplement for me.

[Neo]

@DeStrider

mood.

In addition, I used to have a lot of problems with bronchitis/asthma

This would be helpful for me too. Is there mechanistic rationale/data on this or so far you n=1 experience?

[Neo]

@DeStrider

biology. I take 2.6 g daily along with selenium and molybdenum. Glycine has also been wonderful as well. When it’s time for bed, it just hits me like a brick and I fall asleep instantly

Do you take the NAC before bed too? What timing pre bed for the glycine do you think is optimal?

[DeStrider]

There is mechanistic rationale/data available. You can find videos about it on YouTube and research papers through Google. It is also my N=1 experience. My experience lines up exactly (if not better than) with what the research shows.

[DeStrider]

I take 1.6 g of NAC in the morning along with 4-5 g of Glycine and 11 g of collagen in my morning coffee.

I take 1 g of NAC at night along with 4-5 g of Glycine in my non-caffeinated dinner cold brew tea. I eat dinner at around 7:30 pm and take my supplements and tea after dinner, so probably between 8-9 pm. I go to sleep around 10-10:30 pm.

I feel energized all day. I am surprised that even when I only get 3 hours of sleep in a night (usually 6.5 hours), I don’t feel tired the next day.

[Curious]

There has been quite a lot of interest regarding NAC and psychiatric issues. Mental wellbeing is a potential side effect from NAC. .

N-acetylcysteine in psychiatry: current therapeutic evidence and potential...

N-acetylcysteine in the treatment of psychiatric disorders: current status...

[EnrQay]

I also did the calculations, and agree with you that 7g glycine and 9g NAC (not cysteine, a component of NAC) is what they used for a 70kg person.

[EnrQay]

The Baylor study used 71-80 year olds, whille this one averaged 65 years old. It could be a crucial difference.

[desertshores]

Don’t get me wrong. I am a believer in glycine and NAC supplementation. Not just believing I need a GlyNAC supplement as opposed to my regular supplementation with glycine and NAC.

[adssx]

Are there any reasons NOT to take GlyNAC?

Brad Stanfield writes: “Collagen supplements already have significant quantities of Glycine, plus I already take Trimethylglycine (TMG), so I’m already getting all the glycine that I likely need. Therefore, when I reach 45 years of age, I’ll only add NAC to my supplement stack.”

Could there be detrimental effects of taking GlyNAC before age 45? And… why 45yo? I understand that “there is a continuous, linear increase in oxidative events throughout adult life but that the capacity of the GSH antioxidant system is maintained until 45 years and then declines rapidly”. But shouldn’t the decision be based on your GSH levels (or whatever other relevant tests) and not an arbitrary age limit? What would be the threshold to start GlyNAC supplementation? At which dose?

[L_H]

It may have a nuanced impact re cancer.

NAC and Cancer link updates?

The clearest and most nuanced I’ve found so far is this: At low levels, superoxide/H2O2 induce cell proliferation and promote tumorigenesis and progression, and at higher levels they are cytotoxic to cancer cells and inhibit metastasis. Thus, inhibiting ROS could mitigate tumorigenesis and progression while stimulating metastasis. Antioxidants that directly or indirectly remove ROS affect tumorigenesis, progression, and metastasis of tumor cells differently. NAC was shown to exert paradoxical effects in a mouse lung cancer model [17,18]. NAC treatment enhanced metastasis of lung cancer [16,17]. This could be due to decreased oxidative stress in metastatic tumors, causing them to proliferate and grow in distant sites [17]. Pretreatment of melanoma cells with NAC prior to intravenous injection in mice enhanced tumor formation by tenfold [19]. The findings from the mouse melanoma progression model predict that the use of dietary antioxidants or antioxidant therapy might protect against …

[DeStrider]

Brad picked 45 yo to start as Glycine and Cysteine both suffer noticeable enough drops starting at around 30 that impacts GSH significantly. Starting at 50 yo, ROS shoots up due to a lack of GSH. So he’s adding a 5 year buffer to be careful. These are averages after all.

Cure Deficiencies First (Matt Kaeberlein & Bruce Ames)

Amino Acid Deficiencies Taurine - When we are young (late teenagers) we have a taurine level of 100-300. When we hit age 60, we have a serum taurine level of 50-80. That’s a drop of 50% or more. This also happens for mice and monkeys (and probably all mammals). See picture below. It is reversible with supplementation. [image] Examples of several important insidious long-term pathologies that taurine would protect against are: CVD, brain dysfunction, and diabetes. Taurine effects on CVD have been examined by numerous RCTs and have been reviewed previously (51). Taurine supplementation lowers blood pressure, improves vascular function, and raises plasma hydrogen sulfide levels as shown in a recent RCT with prehypertension patients (58). Taurine consumption was the most significant factor associated with reduced risk of ischemic heart disease (IHD) in two international epidemiological studies of CVD in 61 populations (25 countries; n = 14,000): Japanese people in Okinawa had the…

[adssx]

Thanks. How can I measure my glutathione levels? I could only find Glutathione Peroxidase and Glutathione Reductase tests and I don’t know if they do the job.

[DeStrider]

See video below for testing info.

[DeStrider]

From a top expert on Glutathione. See testing at the 13 minute mark

Glutathione & Longevity – TOP 10 Benefits & 6 WAYS To Increase Your Glutathione Level

[murraci]

NAC almost certainly works against rapamycin.

Here it is nullifying the effects of mTOR inhibitor Ashwagandha.

Here it is completely nullifying the life extension gains of mTOR inhibitor glucosamine.

I also found another study in which rapa was found to block the effects of NAC (and I’m guessing vice versa) but can’t currently find it.

So if people want the benefits of mTOR inhibitors they either have to time their NAC intake very well or ditch it from their program IMO. I’m going with the latter because there’s little evidence outside of Baylor (who have a patent on glyNAC) that raising glutathione levels has any life extension benefits. It’s a theory. Raising NAD+ levels that decline with age is a theory too. NR failed to achieve anything in the ITP though so much for that one.

[murraci]

Here’s the paper I was looking for WRT rapamycin. Its conclusions aren’t positive for thiol antioxidants like NAC.

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in...

[LukeMV]

Where do those links show that NAC nullifies Ashwagandha and Glucosamine?