I really think that the GetHealthSpan Lab packages are really hitting the target. When I go back to the US next, I’ll be getting the Longevity Pro and Rapamycin Level Testing packages. I’m looking forward to finding out more about my health.
Now if only I can find a way to add the Omega-3 index and vitamin D levels!
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@DeStrider Use blood spot tests from omegaquant. Test at home.
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DrFraser, I do appreciate your insight here. FWIW, last week was my first time using GF beforehand. I usually had several tablespoons of EVOO an hour beforehand (6mg) along with taking my usual dose of metformin at about the same time. I know I should have just stayed with my usual dosing, but I was intrigued with the $25 test and wanted to see how the results came out.
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kbaba
#24
Seems like some of the timing recommendations here should be qualified by your practice of using Grapefruit Juice, which is likely to prolong having higher levels in the blood versus those taking higher doses but without grapefruit juice. Of course for you 12 days is a better strategy with a bigger peak to touch the ApoE4 concern.
I am cheap and efficient, like grapefruit (or Pomelo) juice and fruit, and have one ApoE variant so I’ve used similar strategy and timing as you have although have been considering trimming back as I’ve have instances of skin infections and immune susceptibility that makes me question
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I think so long as you measure it, and do it the same way each time, and goal for no more than 30% of the time with a level >3.0 ng/mL, I’ve not yet had increase in any adverse item, including bacterial infections.
I’ve changed my approach to testing, as ultimately, for a 7 day dosing, checking a 50 hours post taking level is perfect, as you want right on 50 hours of levels >=3.0 ng/mL to get ~30% of the time with reasonable mTORC1 inhibition, then the rest of the 70% of the time, in recovery.
So getting that single level then gives individuals a reasonable way to modify dosing logically, without multiple levels being done.
If going for a 14 day dosing interval, then check a 100 hour post dosing level.
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Is this your finding across a range of patient of different ages and gender?
This approach sounds very reasonable btw. I prersonally am doing great on a dose that puts me over a level of 3 roughly 21% of the time, according to blood tests, but have considered increasing the dose by a third, which would just so happen to put me at over 3, 30% of the time.
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Is it a blood draw thru labcorp/quest? Does the consultation cost $25?
@Olafurpall I’ve not had any issues with this approach, and have individuals from in their 30’s to their 80’s. Now I probably only have 150 people on Rapamycin, but this is growing each month, but it’ll take me a while to have the knowledge that Dr. Green had, but it is still a lot of cases and I try to stay in contact and accessible to my patients. So if they have a problem, I get to hear of it.
The blood test I refer my patients for is self ordered, but $48
Rapamycin/Sirolimus Levels: Email: help@hippevoshop.com. This is self-ordered and doesn’t require me to order this. It should be drawn 50 hours (2 days and 2 hours) after you take Rapamycin/Sirolimus.
Their price for LabCorp test 716712 Sirolimus – Whole Blood is $48.00 (ordered through normal means cash pay is usually a bit over $100 so this is the best source currently). Please include the following information to allow us to make a lab requisition: Patient name, Date of Birth, Phone, Address, Email, Payment Information.
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jjrap1
#29
I have a couple questions. At 80 I’ve been using rapa for almost exactly 3 years, currently 5mg+GFJ+EVOO q2w. I recently did the @DrFraser 100 hr sirolimus test; the result: 2.3ng/mL. But at my age does a sirolimus level of 2.3 mean I should bump up my rapa dose by 1-2mg and retest to get it closer to, but not over, 3ng/mL after 100 hrs or leave it alone? Also, at the same time, I did a T test; the result was 490, but the Free T was only 6.4. At 80 should I try to do anything about my low free T level, or could that be a artifact of using rapa 100 hrs previous? Other unfortunate facts: CAC of 391 & ApoE3/4.
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I can’t give you specific medical advice without you being my patient, but I can speak in generalities.
In general goaling for 3.0 ng/mL is sensible at 100 hours if doing every 2 week dosing. Add 1 mg is likely to get the average person very close to this goal.
The low Testosterone wouldn’t be an artifact. Most men do their best in ~75%tile of Free Testosterone. There are multiple ways to make that happen.
In regard to the CAC - in general, if you were my patient, I’d be ordering a CT Coronary Angiogram (cash pay is generally $311-$600) but this gives invaluable information, which could be life saving and modify what is done. Also getting a SimonOne MRI Body Plus (includes head/neck MRA) is sensible both for malignancy screening and for the Neuroquant to look at every section of your brain, particularly tracking Caudate Nucleus and Hippocampus %tile for age/gender over time. This also evaluates for head and neck/brain vascular disease.
Overall having objective imaging to know one’s actual status is critical. Blood work may be indicative, but normal blood work is typical in the patients I see with cancer, stroke, heart attack … so it isn’t sufficient.
Please discuss with your licensed healthcare professional - but those are my general thoughts for the issues present.
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jjrap1
#31
Thank you @DrFraser for your detailed response. Being lucky so far, no symptoms/no events; normal standard blood work. Walk 1-3 mi/day @ zone2 rate, weight train 2X/week, mostly pescatarian diet, normal bmi, ApoB 58 (rosuva+ezet), BP controlled (telmis), etc. I will definitely discuss your suggestions with my PCP.
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Thanks for this @DrFraser. My 48-hour sirolimus blood concentration is 1.9ng/ml after taking 6mg Rapamune with water. I’m considering increasing the weekly dose to 10mg to target 3ng/ml at 48 hours; but it sounds like half-life may get longer the more you take.
When you say “really high doses” extends half-life, what dose level are we talking about? I’m trying to see if assuming a linear dose response from 6 to 10mg is going to make me overshoot significantly.
When folks take enough to still be a 3 ng/mL a week after dosing it seems to look a lot more like the literature for daily dosing where the T1/2 is in the 60 hr range has been what I’ve seen. I have limited data on that, but this is my observation.
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