Anyone taking GG? Is it any better than getting it from EVOO?
I take it in lieu of CoQ10. I thought that was the main point of the video.
3 Likes
I took it for a while because I’m on a statin, but (unsurprisingly) didn’t deterct any positive or negative effects. I ended up stopping after the first bottle and put it on my ‘wait and see’ list of supplements.
I later came across this discussion suggesting it might limit the anti-cancer benefit of statins Stage 4 Pancreatic Cancer - Last Ditch Efforts - #69 by CronosTempi
1 Like
GG changed my life. It took 10 years off how old I felt when exercising. It turned out the problem was a statin intolerance (thats my conclusion). Once I switched to bempadoic acid I didn’t need the GG (that’s the evidence for my conclusion). If you don’t have statin intolerance or don’t exercise vigorously then perhaps GG doesn’t do anything for you. Coq10 was supposed to help with statin issues (muscle pain/weakness) but it never did anything I could feel.
2 Likes
I agree. CoQ10 did nothing to relieve my statin intolerance. Switching statins from Rosuvastatin (10 mg) to Atorvastatin (5 mg) made a huge difference. However, I still experience a twinge of muscle weakness. I’m having a hard time deciding if it is psychosomatic or the low-dose Atorvastatin. I can live with it for the moment as it is orders of magnitude better than what happened on Rosuvastatin.
It may be that the muscle weakness is coming from the days that I take GFJ as it multiplies Atorvastatin too.
1 Like
I understand the desire to relieve statin myalgia in some statin users. Not sure if adding Geranylgeraniol is wise, though, since it exists further up in the mevalonate pathway than the synthesis of Coq10.
https://www.researchgate.net/figure/The-mevalonate-pathway-Inhibition-by-HMGCoA-reductase-by-statins-leads-to-depletion-in_fig2_23251540
The isoprenylated proteins and dolichol are also involved. Much evidence of pleiotropic effects of statins exist re: cancer and inflammation
https://www.sciencedirect.com/science/article/pii/S0925443920303161
" For example, a recent study demonstrated that the inhibitory effects of simvastatin on proliferation, migration, and invasion of gastric cancer cell lines MKN45 and MGC803 was due to inhibition of β-catenin and YAP signaling, as a consequence of reduced GGPP and RhoA activity [128]."
1 Like
@GregordianKnot I got a big benefit from GG when I was taking rosuvastatin. But I quit the statin to not need GG (switched to bempadoic acid).
1 Like
