Bicep
#76
Thanks, same with me. I think it would be an interesting test to have around. Like my daughter with cancer, if they could test they may find she is short and it could be supplemented. It would also help with titration to determine the dose.
BTW, my daughter had a scan at the university of Iowa yesterday and she was declared No Evidence of Disease. She’s more or less clean. Hooray! I think she’s going to keep up with the treatments she’s been using since they are mostly vitamins anyway.
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I’d keep up the treatments for a while longer. Cancer is insidious. Just because it can’t be detected doesn’t mean there aren’t a few survivor cells hiding. Be vigilant and don’t let it make a comeback! However it’s wonderful news that she is better.
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Bicep
#78
https://sci-hub.ru/10.1161/CIRCRESAHA.116.308478
This says the whole thing with gdf11 is just a mistake.
Also Steve says you have to take it frequently for awhile, then still a couple times a month. E5 is supposed to be much less frequent.
Yes, I realize I’m arguing with myself.
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Neo
#79
Not sure I understand
I thought the animal studies (a large number of them now, many in great journals) are controlled, where some animals are given GDF11 vs controls are just given placebo. Hence any effect in the treatment is causally due to the GDF11.
Are you saying that anyone is questioning that?
Bicep
#80
Sometimes you have to click the link in your browser to make it load, I don’t know why.
The writer says GDF8 also called myostatin is hard to distinguish from GDF11 and he claims they find GDF11 goes up as you get older. Very confusing and I’m no biochemist. Also this is from 2016. Beats me, I just saw it and thought I’d share.
1 Like
Jay
#81
RapAdmin, This may have already been posted, but in case not, here is a publication from 2023 Oct 20 about the controversies of GDF-11. In particular, it notes that GDF-11 in humans does not decrease with age (though GDF-8 myostatin does) which I find very interesting. It doesn’t mean that adding more exogenous GDF-11 isn’t beneficial, but I wonder.
As an additional note, I have investigated GDF-11 several times the last few years and other than Steve Perry’s detailed account I find very few people here, on the forum.age-reversal.net or on Reddit who actually state that they’re using it. I even looked at the Facebook forum on GDF-11. When I asked those who were taking it about their results I got responses such as “I noticed nothing” to “I like the effects” but with no further details about the effects, and that was from less than a handful of responses I received. So, it just seems too nebulous to pursue. However, if you have tried it and can provide a precise account of your results that would be great.
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DrT
#82
There are recently published results that clearly show that GDF11 level in plasma of people aged 70+ is zero.
Earlier studies used inaccurate tests that could not distinguish between GDF11 and GDF8. Hence they showed no decline with age.
Many mouse study results should be treated with caution as they used gargantuan doses for the mice.
I have used GDF11 since about 2020, but I am not part of Steve Perry’s group.
I believe Steve has made available copious amounts of results from his participants.
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Jay
#83
DrT,
Thanks very much for the input. In the over 70 area I need all the help I can get. So, if you have time to tell more about your experience with GDF-11, especially any benefits, I would certainly like to hear it. Of course, any studies you can point to would be great, too.
Thanks,
Jay
1 Like
Please share details and results (if you have been able to measure any).
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Neo
#85
GDF11 improves hippocampal neurogenesis and cognitive abilities in diabetic mice by reducing neural inflammation
Highlights
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GDF11 treatment is shown to enhance hippocampal neurogenesis and ameliorate learning and memory deficits in a diabetic murine model.
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Targeted microglial depletion in diabetic mice via CSF1R inhibitor PLX5622 reduces neuroinflammation and improves cognitive function.
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The study delineates the neurogenic underpinnings critical for cognitive restoration, providing a potential therapeutic strategy for diabetes-associated cognitive decline.
https://www.sciencedirect.com/science/article/abs/pii/S0889159124004124
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Bicep
#86
So good to hear they didn’t forget about it. GDF11 has been such a mixed bag of conflicting results from different labs etc… Now it works in diabetic mice by reducing neural inflammation. Thanks Neo,
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More “mixed” results from GDF-11.
Primary GDF-11 proponent / user and biohacker Steve Perry died in August “after a brief illness”. Age 66 (he identifies as 64.5 years old in the 2022 video below).
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This is a shame. Young, and its people like Steve who move things forwards. Regardless of what caused it, it’s a lesson that all of this stuff has risks.
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Bicep
#89
Died suddenly? I’m thinking it had nothing to do with GDF 11.
I wish especially in this case that they would say what killed him. My obit will contain this information one way or another.
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Biology is really complex… I don’t think any post-mortem would ever be able to truly identify the cascade of biological changes that likely precipitated his death.
When a heavy user and leading proponent of an early-stage, experimental, non-FDA approved, and untested (in humans) therapeutic like GDF-11 dies an early death, I would say it increases my interest in waiting to see what the GDF11 clinical trials show…
There is a vast difference between taking an FDA-approved drug that has been in use for 20 years by hundreds of thousands of people around the world (like rapamycin), and injecting a relatively recently-identified chemical (GDF-11) that has little in the way of clinical data, and has gone through no formal clinical testing program, and is sourced from questionable suppliers off-shore…
https://www.nature.com/articles/s12276-020-00516-4
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Pat25
#91
This is really sad news. He had been so invested in GDF11 and the effects he felt it had on his health, and he seemed so full of enthusiasm about the future. Very sad to read this.
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hamtaro
#92
R.I.P. to Steve Perry. Although he was physically active, I think he admitted he did not follow a healthy diet, and didn’t have a healthy BMI. I think he stopped taking GDF11 for the last few years, but I could be wrong.
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I was impressed with Steve’s presentations on GDF-11. I really thought he presented a good case for it. I guess you really need those safety trials and RCTs before you start treatment on yourself. One more reason to be cautious with new treatments.
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Neo
#94
This I 100% agree with. And think he was taking other such compounds too?
For GDF11 I don’t think anyone has made a GMP / quality controlled / medical grade version available, rather all that has existed in the past has been different for research only products - not validated from a quality control perspective the way medicines have to be.
This piece I think needs a bit more nuance: Remember that GDF11 is found in our normal healthy blood and was originally found after analyzing parabiosis. It is natural and not a foreign chemical.
My understanding is that this natural protein is basically the same across all mammals. So in that sense we have hundreds of millions of years of “safety data” (whereas for many FDA approved molecules those are new and foreign to human - and even mammalian - biology).
Still I 100% agree that even natural human proteins or other blood products should be tested in clinical trials.
4 Likes
I’m in 
The titration should not be difficult. Someone posted that…
Found it GDF11 dilution calculation - Google Sheets
And another one…
