Arhu
#162
I still think trehalose makes espresso taste fabulous
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So…what was the conclusion here? Anyone still on the trehalose train?
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Bicep
#164
Well, there is no down side. It mostly just turns into glucose, which is much better for you than the glucose-fructose mix you would need to use otherwise.
I bought a bag of it when the discussion started and am less than halfway through. I put a pinch under my tongue when I’m making my morning smoothie because the bag is next to the collagen and creatine. The idea is that it will go straight into the bloodstream and more trehalose will make it through. Past the trehalase.
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Id love to hear if people think trehelose is worth it? It seems cheap (i saw a 1kg bag for $17 on Amazon). The period of feverish exuberance was summer 2022 so there’s been two full years tro evaluate its results. I believe @desertshores stopped because he didn’t need another gassy supplement. Did anyone think it worked?
Also, is 100-300g per day really the dose? I thought i read 10g was more like it.
I like trehalose and continue to buy it, but identifying and measuring any benefits is really hard to do I suspect. My take in it is if you ever want to use a sweetening agent why not use one that seems like it may have some benefits?
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Thank you, @RapAdmin . That’s a much appreciated vote of confidence (that you are still taking it). I wasn’t really looking for a sweetener (glycine is fine for me) and not sure i want to take 100g of a carb per day (some of the papers / some responses in this thread referenced this) given i am generally low-carb (I seem to blow up like the Stay Fresh Marshmallow Man when i cheat with french baguettes and gelato).
I am trying to keep my supplement numbers down (the anti-Bryan Johnson strategy) and focus more on whole foods and vigorous exercise as my primary healthspan/longevity strategy; I’m personally worried about unintended consequences — or interactions — from taking a large number of supplements, especially considering there seems to be a typical excitement/focus cycle with a “euphoria” phase where the supplement is the best ever, and then that fades away and no-one mentions it for years, and then papers come out that supplement x actually causes cancer (ok, exaggeration). I might also argue that after two years that if you don’t sense a positive change in your health/metrics/age clock measurements, is it really doing anything positive?
Has anyone been taking trehalose for the past two years and seen positive indications from it? It’s cheap, aside from being a carb appears to be benign, and could help with autophagy, insulin resistance, Alzheimer’s, and a host of other benefits, so its on my short list to try, but not if others here have known about it for two years and find it “meh”.
Thank you.
Bicep
#168
I put about a teaspoon under my tongue while making breakfast. I’m sure it does very little but it tastes good and I don’t see the down side. At this rate that bag will last me about a decade.
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I appreciate that, @Bicep .
You feel it does very little: is that just that you don’t feel “different” or “better” after taking it for several years? Or you don’t see much difference in blood/health metrics?
One teaspoon is roughly 40% of a tablespoon, which I believe someone referenced that being 8g (Ive seen 10 as well: maybe a metric teaspoon versus an imperial?) So you are taking roughly 3-4g per day?
I also keep reading it “prevents/reduces visceral fat”. THAT would be nice for me, for while I have gotten into the best shape of my life (strength-wise, and equivalent endurance as when I was in grad school, although much lower tolerance for alcohol) i still have small “dad bod love handles” which masks my progress, so this would be nice to lose. I can’t seem to lose it without fasting much more regularly (not anxious to stress my body for vanity reasons, as I’m married so what’s the point). A friend wants me to try microdosing testosterone which keeps him very lean and ripped, but with one kidney and no sexual issues that i am aware I am loathe to mess up what already seems to work.
My daughter is a newly-diagnosed (just over a year) Type-1 Diabetic so this might be a nice sweetener for her as well.
Bicep
#170
It’s pretty much just 2 glucose molecules hooked together a little different way if I remember right. Very quickly converted to glucose, in fact there is a special enzyme made just for that which is why I put it under the tongue.
I wouldn’t give it to a type 1 diabetic. My mom was T1D for nearly 50 years. If it was me, I’d go with no sweenteners but inulin, erythritol or xylitol in small amounts work.
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It’s interesting you say this, as i agree with you that this is the obvious thought. But while looking at papers I saw that this is being investigated as a Type-2 diabetes treatment (reduced insulin resistance) and in T1D as well. There’s also an impact of 30-ish percent decrease in blood glucose spikes, and lower incidence of insulin spikes as well (although i cannot remember if trehalose was administered in addition to 100g of glucose, or if it replaced 100g of glucose — big difference).
Obviously eating very few carbs is probably the best solution as (given the differing rates of food glucose absorption versus injectable insulin rates) the spikes and crashes from these mismatches will be much smaller in a lower carb diet (lower perturbations around the mean). But if you can reduce the glucose spikes in other ways — drinking a small thimbleful shot of vinegar before eating carbs reduces your stomach from enzymatically breaking complex carbs into glucose, and pushes these chains deeper into your intestines instead where much of it will pass through unused by your body — this could help too. Trehalose could help here even in T1D’s.
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Thank you, @desertshores . “Meh” is useful to prune my supplement stack.
This seems interesting and relevant to this thread:
Boosting autophagy improves amyloid beta clearance
What goes down can come up. When the researchers tried overexpressing the autophagy gene LC3B specifically in astrocytes in Alzheimer’s-prone mice, this significantly decreased the number of amyloid beta plaques in the hippocampus. Boosting autophagy also led to a substantial increase in the number of functional neurons and to an improvement in cognitive and spatial memory functions.
Finally, the researchers transfected human astrocytes with viral LC3B plasmids and, after 24 hours, exposed them to amyloid beta. Just like in mice, LC3B overexpression improved mitochondrial function and decreased the levels of active caspase-3, a marker of cell death.
According to Korea’s National Research Council of Science and Technology, Dr. Ryu and Dr. Suhyun Kim (the first author on the study) said about their research, “Our findings show that astrocytic autophagy restores neuronal damage and cognitive functions in the dementia brain. We hope this study will advance our understanding of cellular mechanisms related to autophagy and contribute to future research on waste removal by astrocytes and health maintenance of the brain.”
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"Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo"
“Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia, corticobasal degeneration (CBD), and chronic traumatic encephalopathy”
Methylene blue and autophagy.
Can methylene blue pass the blood brain barrier?
“Several studies have demonstrated this capability. For instance, research has shown that MB can cross the BBB and accumulate in brain mitochondria, where it acts as a redox mediator in the electron transport chain.[1] Additionally, MB has been observed to enhance brain metabolism and hemodynamics, further indicating its ability to penetrate the BBB.”
“Moreover, studies involving animal models have confirmed that MB can cross the BBB and exert neuroprotective effects. For example, in a study on rats with chronic cerebral hypoperfusion, MB was shown to cross the BBB and improve cognitive function by enhancing mitochondrial function.[3] Another study demonstrated that MB could reduce neuronal apoptosis and improve BBB integrity after traumatic brain injury in rats.”
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