#61

AFAIK, he’s a minister in some church i do not remember and he often speaks about insulin resistance in his sermons, recommending a low-carb diet.

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#62

On the substantive point, however, there was a case of someone who was prescribed daily rapamycin following a lung transplant and managed to take ten times the prescribed amount. This person suffered from muscle loss and ended up falling several times which is how the overdose was spotted.

This does not surprise me. The obvious symptom of a restriction in cell division is the loss of lunulae. As I am probably the least frequent doser when it comes to Rapamycin I still have lunulae on most of my fingers and I don’t have records to spot when and if i ceased having lunuae on any fingers.

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#63

I have lunula on my thumbs only, but have lost them on all my other fingers.

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#64

Its hard to tell when the lunula is really small, but I definitely have 4 on the left and 3 on the right, but may be developing a 4th on the right.

Sadly, however, I have not got historic records going back before when I started on rapamycin. However, my current dosing regime (which is now less frequent than every 42 days) appears to be helping with the lunulae. The big question, of course, is whether it also helps with improving mitochondria enough.

I am currently waiting for an inflammation to go before my next dose of rapamycin. I think the last one (which was 16 plus multiplier) had specific identifiable effects on improving mitochondria in my scalp. That would imply a systemic improvement. However, I was away from my normal base and therefore unable to track things in sufficient detail so I am not sure.

I have been studying the records of what is an overdose and when negative effects occur. Inyerestingly the normal daily maximum dose is 40mg. Someone tried to commit suicide with rapamycin with 103mg and failed to suffer any long term consequences. It compares to melatonin where there are a number of case reports of people trying to commit suicide, but instead having a healthy nap. The LD/50 for Rats cannot be measured for rapamycin being over 2,500mg per kg. There was a video that looked at very high doses of 500mg and 1g, but I am not tempted by that approach. Taking my 16 to 22 would extend the highest concentration by about 27 hours so that might be a possibility. However, what is clear about rapamycin is not to take it if you need your immune system in an optimal state.

I am also planning on blood tests twice a week when I take the next dose with the lab that gives the broadest testing range, but I am trying to get them to change the way they handle the results first.

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#65

I have finally settled on 14 mg weekly. That seems like the threshold before I develop too annoying side effects. (I just get a few small itchy hives at this level which appear in different places).

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#66

Interesting. I have lunulea on 3 fingers of each hand: thumb, index, middle. Google says lunulea disappearance correlates with aging and certain deficiencies.

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#67

I have the same, identical situation, without ever taking rapamycin.

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#68

I think lunula disappearance does correlate with aging, but is also affected by rapamycin. It is a visible sign of reduced nail growth.

I have now listened to Ben Bikman’s video against rapamycin. He makes the normal points about the reduction of cell division and says people should fast rather than take rapamycin.

There is an interesting point about insulin resistance. Arguably there would be a point at which the additional mtDNA damage from higher glucose levels does more harm than the additional autophagy from inhibiting mTOR achieves.

Potentially, therefore, when taking rapamycin higher doses of melatonin should be taken to reduce the harm from high glucose.

Otherwise his video does not really consider cycling in the context of rapamycin.

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#69

Or take Metformin, Acarbose or an SGLT2I with Rapamycin. I think this is a correct assumption.

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#70

Ben Bikman is on my list of “do not pay any attention to this person”. I won’t read anything he writes or listen to anything he says….just to avoid polluting my mind. That’s not to say he isn’t right, but we all have to wade through the muck the best way we can.

It is becoming fashionable to bash rapamycin now that rapamycin is becoming mainstream. Soon it will be rapamycin is against God’s plan, and eventually it will be everyone always knew rapamycin was good.

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#71

I have been doing calorie restriction since February. My lunula are only visible on my thumbs and barely on my forefingers. Growth has definitely slowed if this can be considered a reliable indicator.

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#72

I think lunulae are a useful indicator because of their visibility. However, we don;t have enough research on what happens with them to have totally solid conclusions. The situation is different for different people.

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#73

I have lunulae on all my fingers. And they are not small.

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#74

Great points. Could make a comparison to aspirin. While aspirin has pro-coagulant effects, it also has stronger anti-coagulant effects, so the sum effect is anticoagulation.

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#75

I’ve had the same 7 lunulae for the last 11 years fwiw. For a short spell when I had ‘Long Covid’ they seemed to be shrinking but now they are back to normal so rapa doesn’t seem to have impacted mine.

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#76

Not on rapa yet, and have them only on my thumbs.