I wrote some notes on increasing Oxygen while sleeping, as it sounds a possible promising passive biohacking worth the effort Increasing oxygen while sleeping? – Hacking Biology .
While i’ve started from this research on the improve of Oxygen increase while sleeping i’ve dig into the topic, whereby seems a lot of people with sleep apnea problems end-up supplement oxygen to improve their sleep.
I’ve just researched the way to make it “accessible” in a non-invasive way (who want to sleep with a mask?), in order to starts experimenting it.
Did anyone already engaged in supplementing oxygen while sleeping?
Fabio
Hacking Biology project
Chronic hyperoxia does cause harm. Where the threshold is on this I don’t know. Short periods of hyperoxia (such as in HBOT) are ok.
I wrote about this here:
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Definitively there are risks with too much hyperoxia, and HBOT at 2 ATA for 90min is surely a top things todo (i’m looking to convince local HBOT center to do the alternating hyperoxia/hypoxia protocol), increasing by 10x/15x the oxygen plasma concentration for a while.
Still it’s interesting to analyze what we can do passively while sleeping, so i ended up analyzing the work being done by medicine on those afflicted by obstructive sleep apnoea (OSA), that without the extra oxygen would be in hypoxia condition leading to a lot of sleep and metabolic problems.
Most of those goes with a mask or cannula to sleep, while this product seems to be very interesting in the ergonomics / accessibility:
So i am wondering, in a normobaric pressure during the 7-8h of sleep, what would be a reasonable oxygen supplementation given the effect in increasing NREM / deep sleep phase of the research above, without leading any toxicity effects?
Fabio
Best to read my blog post which gives a tool to compare hyperoxic exposures. Definitely avoid stimulating nf kappa b, personally i would stick to hif 1 alpha and avoid levels that stimulate nrf2
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Read all your extensive post, getting more in the topic of playing with oxygen to trigger HIF-1 alpha, my understanding is that for the magic, we just need is intermittent hyperoxia that induces the normobaric oxygen paradox (NOP), when following hyperoxia we bring oxygen to normoxia, hacking our biology in thinking we’re in a hypoxia stress condition.
Modulating an oxygen concentrator that way, would be quite easy to have such a passive pillow-placed non-invasive oxygen dispenser.
It could be then interesting to have such a passive system that, while sleeping at normobaric pressure, would bring few session of increase of oxygen and decrease of oxygen, rather than just increasing oxygen as per sleep apnea obstruction treatments.
I am wondering if doing this at normobaric pressure, still bring HIF-1 alpha activation?
Fabio
The research indicates that, yes.
I am really wondering, whenever HIF-1 alpha activation is the key master regulator that bring the effectiveness of the HBOT oxygen alternating protocol being used by Shari Efrate in Israel that do bring telomere increase and immunosenescense decrease.
The experiment of @Paul with Live2o.com device can be very valuable to see some results on that outcomes, especially in terms of accessibility.
Fabio
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I think it is HIF 1 alpha that is at the centre of a lot of things including HBOT.
I don’t, however, think telomere length is that big a thing as replicative senescence isn’t really the case of human senescence. I think telomerase is important because it benefits the mitochondria as well as extending telomeres.
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adssx
#9
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