#41

@Curious, hmmmm, this is interesting - also taking into account ITP results for glycine and GlyNAC (but mouse is not homo sapiens)…

Here is my version.

The study (Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study | BMC Medicine | Full Text), after correcting for multiple testing, found a positive association between glycine and the risk of overall prostate cancer in younger subjects. It’s important to understand that this association does not necessarily imply a causative role of glycine in promoting cancer cell proliferation. Instead, it could be indicative of altered metabolic processes in cancer cells, where glycine, along with other metabolites, is involved but not necessarily the driving factor in cancer progression.

Another study (https://www.sciencedirect.com/science/article/pii/S2211124714003477) provides additional context, showing that while cancer cells require serine and glycine for nucleotide synthesis and one-carbon metabolism, it’s actually serine consumption that is crucial for cancer cell proliferation. This distinction is key. In the first study, the observed association with glycine might reflect broader metabolic changes in cancer cells rather than direct utilization of glycine for growth. In essence, the presence of glycine could be more of a biomarker of altered metabolic states in cancer cells rather than a direct contributor to cancer development.

But this is my best guess - looking forward to opinion of community.

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#42

The Serine/Glycine cancer connection has been discussed in other topics. The studies typically found that glycine was neutral in relation to cancer, but serine fed cancer growth. So, glycine is preferable over serine.

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#43

Thank you for your thoughts. At species level, human biology is complex and at a personal level it shows large individual variations in the biological processes. So I really look forward to a more personalized medicine.

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#44

I have read (don’t remember where) that 5 alpha-reductase inhibitors only reduce the risk of low-grade PC.

In Attia’s interview with Dr. Schaeffer they say that a danger with these drugs is that they suppress PSA.
PC can be missed if your doctor doesn’t know that your PSA number is artificially low.

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#45

10 years after being first diagnosed with PC, I have seen no progression without any medical treatment
At that time my Vit D level was 19 ng/ML and BS was elevated
For the first 6 years I supplemented with Vit D to get me in the 60-80 range, took Dutesteride and metformin
About 4 years ago I added rapamycin and a low carb diet - eliminating sugar
Also added LDN in the past year
So far, so good

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#46

In the meantime I have found solution for “bad” taste of cold-brewed tea with moringa as recommended by Dr. Jed Fahey. Water has to be simply replaced with almond milk. Taste of almond replaces moringa aftertaste and texture very well. Up2everyone to try.

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#47

An interesting paper:

Results: The major finding of in vivo studies was consistently lower citrate levels in prostate cancer compared with BPH and normal prostate peripheral zone. This was reflected by significantly (P < 0.05) lower mean citrate/(creatine plus choline) peak area ratio observed for regions of cancer (0.67 +/- 0.17) compared with BPH (1.21 +/- 0.29) and normal peripheral zone (1.46 +/- 0.28). Moreover, there was no overlap of individual cancer and normal peripheral zone citrate ratios and no significant difference between citrate ratios in regions of normal peripheral zone in young volunteers (1.28 +/- 0.14) and age-matched patients (1.46 +/- 0.28). The observed alterations in vivo citrate levels were supported by citrate concentration data obtained from extracts of histologically proven samples of normal, benign, and malignant prostatic tissues removed at surgery. In vitro citrate levels in the normal peripheral zone (30.9 +/- 8.5 mumol/g wet weight) and BPH (46.3 +/- 5.4 mumol/g wet weight) were significantly higher than those for prostate cancer (3.74 +/- 0.54 mumol/g wet weight).

Conclusions: These studies further demonstrate the potential of citrate as an in vivo marker for discriminating prostate cancer from surrounding regions of normal peripheral zone and BPH.

What I find interesting here also is that one function of the Prostate is to inject additional citrate into seminal fluid. I think the benefit of this is that when an egg is fertilised there is likely to be a higher level of acetyl-CoA available for histone acetylation and protein creation.

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#48

Yes, moringa tastes like crap. I put it in smoothies, but even then, with berries, etc. its not exactly a helpful addition in the taste area. I also add almond milk to my smoothies (unsweetened, vanilla flavor) and that helps too. But more generally, I find Moringa a hard product to consistently take due to taste issues.

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#49

I recently came across an good article titled “Eating Your Way to Prostate Cancer”: it connects various puzzle pieces around the arachidonic acid pathway and its role in prostate cancer, highlighting the roles of aspirin, omega-3, and omega-6 fatty acids:

  • Omega-3 fatty acids, can reduce prostate cancer risk, while diets high in omega-6 and saturated fats increase it. These bad fats convert to arachidonic acid, stimulating 5-LOX production, which then promotes prostate cancer progression.

  • 5-LOX is over-expressed in prostate cancer and promotes tumor growth factors like epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF).

  • Nutrients like fish oil, lycopene, and saw palmetto extract suppress 5-LOX activity, which may contribute to their beneficial effects on the prostate.

  • Boswellia plant extracts are effective in inhibiting 5-LOX.

  • Aspirin, by inhibiting cyclooxygenase enzymes involved in the arachidonic acid pathway, may offer some protective effects against prostate cancer progression.

As always, main question is, how often and to which extent should we inhibit 5-lox (as it obviously plays a role in immune response)…

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#50

My father passed of aggressive prostate cancer at 67 and his dad at 70. Horrible disease when it spreads to bones. Painful. As a result I have been getting PSA tests yearly since age 19. I have taken finesteride to keep my hair, i also take tadalafil for BPH. My urologist had me genetic tested for the aggressive prostate cancer gene you may want to do that too. Mine came back negative (not foolproof of course), but has given me peace of mind.

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#51

Rapamycin is one of the strongest 5-LOX inhibitors, so thats a positive for all us using that.

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#52

@Goran, could you explain, how Rapamycin inhinits 5-LOX or reference any study, mentioning this pathway? Thanks.

#53

Inhibiting Mtor inhibits the 5-LOX. It was discussed a day ago on the rapamycin group on FB

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#54

@Danlalane, I’m truly sorry to hear about your father. It must have been incredibly difficult to see him go through that. My father also battled prostate cancer, which eventually spread to his bones, causing immense pain. It was a heart-wrenching experience.

I recently discovered that I have the gene for aggressive prostate cancer, so I’m actively working to counteract it, hoping there’s still time.

Below, I’ve compiled a list of interventions that have clear evidence for prevention, based on the last 50 messages, to help everyone easily access this valuable information (this is for informational purposes and not a recommendation or medical advice):

  1. Regular exercise is widely recognized for its overall health benefits and is specifically associated with reducing the risk of prostate cancer and improving prostate health
  2. Finasteride (+Tadalafil?): seems to counteract for both BPH and prostate cancer, but side effects have to be considered;
  3. Testosterone Replacement Therapy (TRT): some discussions suggest a potential link between TRT and prostate health, especially in terms of free testosterone levels; but balance in terms of BPH has to be found.
  4. NRF2 activators: Moringa Oleifera/Astaxanthin/Sulforaphan: known for protective role in prostate cancer by upregulating detoxifying enzymes.
  5. Direct inhibitors of 5-LOX: like Boswellia Plant Extract: effective in inhibiting 5-LOX, which is over-expressed in prostate cancer.
  6. Folate (not folic acid): a study showed a lower risk of prostate cancer in men with sufficient dietary folate.
  7. Vitamin D Supplementation: linked to beneficial effects in managing prostate health.
  8. Omega-3 Fatty Acids: may reduce prostate cancer risk.
  9. Zinc: is known for its role in immune function and cellular metabolism, and it’s considered beneficial for prostate health.
  10. Alpha and Gamma tocopherols: have antioxidant properties and have been studied for their potential protective effects against prostate cancer.
  11. last but not least → staying sexually active: two studies appear to show that men who have a higher frequency of ejaculation were up to two-thirds less likely to be diagnosed with prostate cancer.

This list is compiled from community discussions for general information. Always consult healthcare professionals for personalized medical advice and treatment plans.

Wishing everyone robust health and well-being!

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#55

If you take both finasteride and tadalafil your risk of side effects is effectively 0 :wink:

  1. Alpha and Gamma tocopherols: have antioxidant properties and have been studied for their potential protective effects against prostate cancer.

Wasn’t there a study looking at megadosing vitamin E which raised risk for prostate cancer?

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#56

Yes, synthetic alpha tocopherol shown to increase prostate cancer risk. But according to my research alpha- and gamma-tocopherols work together: alpha form inhibits the production of cell-damaging free radicals, while the gamma form captures and neutralizes them. If the alpha-tocopherol level gets too high in the body, it tries to eliminate gamma-tocopherol in the cells. Therefore, both forms of vitamin E have to be kept in relative balance: Plasma, Prostate and Urine Levels of Tocopherols and Metabolites in Men after Supplementation with a γ-Tocopherol-Rich Vitamin E Mixture + Synthetic Alpha Tocopherol Shown to Increase Prostate Cancer Risk .

So, everyone has to decide on their own risk/value ratio.

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#57

Thank you for the sentiments @SilentWatcher, sorry for you as well. How old was your dad? While I would do anything to have had my dad live beyond my 28th year, attend my wedding, see my kids, see me own a home etc I am grateful that his suffering was a catalyst for me to live my life to the fullest and embrace fitness and wellness with abandon.

Your list of preventative measures is good and comprehensive. I do two more: 1/ lycopene supplementation 2/ avoid chemical exposure. I am convinced my dad and his dad got cancer because they were gentlemen dairy farmers in NH/US. They were exposed to lots of pesticide, chemicals(like weed killer), and had their hands in gas and oil constantly fixing tractors and whatnot.

Godspeed in your pursuit for a prostate cancer free life. Having the gene :dna: is also not a death sentence. Your lifestyle choices and the fact that the tests are not entirely predictive and accurate should give you lots of hope.

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#58

My grandfather died of prostate cancer that spread to his bones at the age of 78. My father got prostate cancer in his early 70s and had it removed at 75. It spread to his lymph nodes and bladder. He underwent radiation therapy and has been cancer free for the past two years. You can slay this monster.

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#59

New product / company idea: Ultrasound underwear to track your prostate health … sort of like this:

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#60
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